Enlarged perivascular spaces in subcortical white matter are linked to amyloid-tau depositions and cognitive decline: Data from a memory clinic in Thailand [0.03%]
皮层下白质血管周围间隙扩大与淀粉样蛋白-tau沉积及认知功能下降相关：来自泰国记忆诊所的数据
Kittithatch Booncharoen,Poosanu Thanapornsangsuth,Thanakit Pongpitakmetha et al.
Kittithatch Booncharoen et al.
Introduction: Enlarged perivascular spaces (EPVSs) have been implicated in Alzheimer's disease (AD) pathogenesis, but their relationships with amyloid beta (Aβ) and tau pathology remain unclear. ...
The collection of speech data for the assessment of cognition remotely: Balancing ethical and practical challenges [0.03%]
兼顾伦理与实践挑战的远距离语音数据收集在认知评估中的应用
Stina Saunders,Fasih Haider,Alyssa M Lanzi et al.
Stina Saunders et al.
Speech biomarkers could form a critical step in improving the accessibility, scalability, and early detection of Alzheimer's disease and related dementias. However, ethical and practical challenges remain across regulatory and cultural cont...
Redefining the norms: an interdisciplinary perspective on language testing in multilinguals with acquired and progressive neurogenic disorders [0.03%]
重定义标准：关于获得性和进行性神经病变多语言的语言测试的跨学科视角
Alessa Hausmann,Adolfo M García,Ana Sofia Costa et al.
Alessa Hausmann et al.
Accurate language assessment is essential in clinical and research contexts. However, most assessment tools and questionnaires have been developed within monolingual frameworks, overlooking the particularities of the vast multilingual popul...
Metabolic and renal factors associated with plasma phosphorylated tau analytes used to detect Alzheimer's disease pathology [0.03%]
与用于检测阿尔茨海默病病理学的血浆磷酸化tau相关的代谢和肾脏因素
Kao Lee Yang,Yue Ma,Gilda Ennis et al.
Kao Lee Yang et al.
Introduction: We examined the extent to which insulin resistance (IR), type 2 diabetes mellitus, obesity, and kidney function are associated with plasma phosphorylated tau (p-tau) concentrations (p-tau181, p-tau217, p-tau...
Atrophy signature for alpha-synuclein copathology in Alzheimer's disease [0.03%]
阿尔茨海默病患者伴路易小体蛋白病理损害的萎缩标志物
Diana Esteller-Gauxax,Núria Guillén,Neus Falgàs et al.
Diana Esteller-Gauxax et al.
Introduction: Brain atrophy patterns in Alzheimer's disease (AD) are well established, however, the contribution of alpha-synuclein (α-syn) copathology to these patterns remains unclear. This study investigates magnetic ...
Automated analysis of expressive prosody in Dutch patients with behavioral variant frontotemporal dementia and primary progressive aphasia [0.03%]
荷兰行为变异额颞叶痴呆和原发进行性失语患者的表达性语调的自动化分析
Lize C Jiskoot,Olaiya Aro,Liset de Boer et al.
Lize C Jiskoot et al.
Background: Previous studies have demonstrated impaired expressive prosody in patients with frontotemporal dementia (FTD), but have been conducted in English-speaking cohorts. To examine whether findings generalize across...
Lecanemab treatment modulates brain volume and cerebrospinal fluid pathways in early Alzheimer's disease: Insights from longitudinal magnetic resonance imaging [0.03%]
莱卡内单抗治疗可调节早期阿尔茨海默病患者脑容量和脑脊液通路：纵向磁共振成像提供的见解
Yuxin Li,Yang Zhao,Aocai Yang et al.
Yuxin Li et al.
Introduction: Lecanemab provides clinical benefits in early Alzheimer's disease (AD), but its longitudinal effects on brain structure, particularly cerebrospinal fluid (CSF) compartments, remain unclear. This study examin...
Association between Alzheimer's/Parkinson's diseases and cancers: Modifying effects of alcohol consumption and viral infections revealed by an ecological study [0.03%]
基于生态学研究的阿尔茨海默病/帕金森病与癌症之间的关联：饮酒和病毒感染的修饰效应
Wenyu Ye,Ziqi Zhang,Sha Ye et al.
Wenyu Ye et al.
Introduction: An inverse epidemiological association exists between Alzheimer's and Parkinson's diseases (AD/PD) and certain cancers. Using a sex-stratified approach, this global study clarifies shared and distinct mechan...
Real-world use of lecanemab: patient pathway findings from a US multicenter study [0.03%]
关于仑卡奈单抗的现实世界应用：一项美国多中心研究中的患者途径发现
Michael Rosenbloom,Courtney Adams,Brooke Allen et al.
Michael Rosenbloom et al.
Introduction: To ensure Alzheimer's disease-modifying treatments can be initiated in diverse populations, efficient pathways to obtain timely diagnoses are required. ...
Clinical and MRI features associated with amyloid positivity in secondary screening for anti-amyloid-β therapy [0.03%]
针对抗淀粉样蛋白治疗的二次筛查中与淀粉样蛋白阳性相关的临床和磁共振影像特征
Kazuki Yamada,Masanori Kurihara,Yusuke Akitomi et al.
Kazuki Yamada et al.
Introduction: In Japan, confirmatory biomarker testing for Alzheimer's disease (AD) is insurance-covered only when evaluating eligibility for anti-amyloid-β therapies. This study aimed to identify clinical and magnetic r...