Sid E O&#x;Bryant,Tanis J Ferman,Fan Zhang et al.
Sid E O&#x;Bryant et al.
Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia wit...
APOE ε4, the door to insulin-resistant dyslipidemia and brain fog? A case study [0.03%]
APOE ε4：胰岛素抵抗性血脂异常和脑雾的罪魁祸首？一例报告
Seth Stoykovich,Kelly Gibas
Seth Stoykovich
For decades, scientists have known that carriers of the apolipoprotein E ε4 (APOE ε4) allele (homozygous/heterozygous) are at respectively higher risk for developing Alzheimer's disease (AD). Although previous research reveals that the AP...
Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease [0.03%]
基于淀粉样蛋白和tau结构的生物标志物在阿尔茨海默病性痴呆患者两阶段识别策略中的应用：血浆与脑脊液标志物联合检测框架
Andreas Nabers,Henning Hafermann,Jens Wiltfang et al.
Andreas Nabers et al.
Introduction: Alzheimer's disease (AD) diagnosis requires invasive CSF analysis or expensive brain imaging. Therefore, a minimal-invasive reliable and cost-effective blood test is requested to power large clinical AD tria...
The incidence of mild cognitive impairment: A systematic review and data synthesis [0.03%]
轻度认知障碍的患病率：系统评价和数据合成
Cai Gillis,Fariba Mirzaei,Michele Potashman et al.
Cai Gillis et al.
Introduction: Incidence estimates of mild cognitive impairment (MCI) range widely. We obtained contemporary age-specific MCI incidence rates and examined sources of heterogeneity. ...
Breadth and depth of working memory and executive function compromises in mild cognitive impairment and their relationships to frontal lobe morphometry and functional competence [0.03%]
轻度认知障碍的工作记忆和执行功能的广度和深度及其与前额叶形态计量学和功能性胜任能力的关系
Leticia Garcia-Alvarez,Jesus J Gomar,Amber Sousa et al.
Leticia Garcia-Alvarez et al.
Introduction: The extent of working memory (WM) and executive function (EF) impairment in mild cognitive impairment (MCI) is not well-characterized. Metho...
What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health-care professionals? A systematic review [0.03%]
轻度认知障碍或阿尔茨海默病患者、照料者及卫生专业人员关注的重要结局是什么？一项系统综述
Claire Tochel,Michael Smith,Helen Baldwin et al.
Claire Tochel et al.
Introduction: Clinical trials involving patients with Alzheimer's disease (AD) continue to try to identify disease-modifying treatments. Although trials are designed to meet regulatory and registration requirements, many ...
Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women [0.03%]
主观认知下降，APOE ε4和男性和女性的轻度认知障碍事件性
Diana Müller-Gerards,Christian Weimar,Jessica Abramowski et al.
Diana Müller-Gerards et al.
Introduction: Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately. ...
Posttraumatic stress disorder and total amyloid burden and amyloid-β 42/40 ratios in plasma: Results from a pilot study of World Trade Center responders [0.03%]
后创伤应激障碍与血浆总淀粉样蛋白负荷和淀粉样蛋白-β 42/40 比值：来自“9·11”世贸中心救援人员试点研究结果
Sean A P Clouston,Yael Deri,Erica Diminich et al.
Sean A P Clouston et al.
Introduction: Chronic posttraumatic stress disorder (PTSD) is associated with poor memory and increased burden of various degenerative cerebral neuropathologies. The goal of this pilot study was to determine whether PTSD ...
Predicting time to dementia using a quantitative template of disease progression [0.03%]
利用疾病的定量模板预测痴呆症的发病时间
Murat Bilgel,Bruno M Jedynak
Murat Bilgel
Introduction: Characterization of longitudinal trajectories of biomarkers implicated in sporadic Alzheimer's disease (AD) in decades before clinical diagnosis is important for disease prevention and monitoring. ...
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration [0.03%]
血管因素导致神经退行性病变的脑磁共振成像方法协调研究
Eric E Smith,Geert Jan Biessels,François De Guio et al.
Eric E Smith et al.
Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on...