Prolonged disease-free survival with immunotherapy combined with chemotherapy in a patient with advanced stage large cell neuroendocrine carcinoma of the uterus [0.03%]
免疫治疗联合化疗使晚期子宫大细胞神经内分泌癌患者获得持续的无疾病生存期
Katherine Yoh,Marie C Smithgall,Gabriela Tessler et al.
Katherine Yoh et al.
Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare and aggressive high-grade neuroendocrine malignancy that only infrequently arises in the uterus. Owing to its rarity, there are no standardized treatment g...
Intracranial activity of mirvetuximab soravtansine in platinum-resistant high-grade serous ovarian cancer: Insights from a patient with central nervous system metastasis [0.03%]
Mirvetuximumab Soravtanzumabe在铂耐药的高级别浆液性卵巢癌颅内活性：一项中枢神经系统转移患者的报告
S Ramalho,T Martins,I Pinho et al.
S Ramalho et al.
Background: Ovarian cancer is the most lethal gynaecologic malignancy, often diagnosed at advanced stages due to nonspecific early symptoms. Although most patients initially respond to platinum-based chemotherapy, recurre...
Aaryan R Jadhav,Brandon L Fong,Mary R Schwartz et al.
Aaryan R Jadhav et al.
Introduction: Extragastrointestinal stromal tumors (EGISTs) are rare mesenchymal neoplasms that originate outside the gastrointestinal (GI) tract and share histologic and immunohistochemical features with gastrointestinal...
Variations and patterns in germline and somatic testing by age in ovarian, primary peritoneal, and fallopian tube cancer patients: a descriptive analysis in a large, real-world clinical and genetic data registry [0.03%]
基于大型真实世界临床和基因数据登记处的卵巢癌、原发性腹膜癌和输卵管癌患者的胚系和体细胞检测的年龄差异及模式：描述性分析
Martins Ayoola,Alexandra Smick,Miles Morrow et al.
Martins Ayoola et al.
Objective: To evaluate the relationship between genomic instability score and age distribution in ovarian, primary peritoneal, and fallopian tube cancers and to characterize age-related patterns in germline, homologous re...
Malignant transformation of a testosterone-secreting ovarian steroid cell tumor: a case report [0.03%]
睾酮分泌型卵巢类固醇细胞肿瘤恶变1例报告
Ravi Desai,Daniel Bravo,Pelin Onur et al.
Ravi Desai et al.
Background: Ovarian Steroid Cell Tumors (SCT) are rare sex cord-stromal tumors accounting for less than 0.1% of ovarian neoplasms. Most are hormonally active and present with symptoms of androgen excess. Steroid cell tumo...
Risk of venous thromboembolism following human papillomavirus vaccination: a systematic review and meta-analysis [0.03%]
人乳头瘤病毒疫苗接种后静脉血栓栓塞风险的系统评价和meta分析
Yushu Wang,Guangyu Ao,Claude Hughes
Yushu Wang
Background: Sporadic reports linking human papillomavirus (HPV) vaccination to venous thromboembolism (VTE) have raised safety concerns. We intended to provide an updated and comprehensive evaluation of this potential ass...
Real World Outcomes of Pembrolizumab and Reduced-Dose Lenvatinib in Recurrent Endometrial Cancer by Platinum and p53 Status [0.03%]
派姆单抗和减量剂量乐伐替尼治疗铂类和p53状态的复发性子宫内膜癌的真实世界预后效果研究
Alexa Dzienny,Yasmin Abozenah,James Griffith et al.
Alexa Dzienny et al.
Objectives: The objective of this study was to evaluate the efficacy of pembrolizumab and lenvatinib in recurrent endometrial cancer (EC) by platinum resistance status and p53 status, and to compare outcomes between patie...
Fertility desires and outcomes in patients with selected hereditary cancer syndromes [0.03%]
遗传性癌症综合征患者生育意愿及其结局
Elizabeth A Connelly,Christina M Lowry,Chelsea Camara et al.
Elizabeth A Connelly et al.
Objective: Limited data exist on pregnancy desires, outcomes, or referral rates in patients with gynecologic hereditary cancer syndromes. This study describes fertility desires and pregnancy outcomes in patients with newl...
Pathological complete response following systemic therapy with carboplatin-paclitaxel plus pembrolizumab for initially unresectable mismatch repair-deficient advanced endometrial cancer: two case reports [0.03%]
卡铂-紫杉醇联合派姆单抗治疗初诊不可手术的错配修复缺陷型晚期子宫内膜癌病理完全缓解两例报告
Nanami Uetake,Shiho Miura,Yurina Suzuki et al.
Nanami Uetake et al.
Background: Mismatch repair-deficient (dMMR) endometrial cancer is highly sensitive to immune checkpoint inhibition. Although pembrolizumab combined with carboplatin and paclitaxel is now a first-line standard treatment f...
The challenges of implementing less invasive surgical management for cervical cancer in a limited-resource setting in Botswana: A case series [0.03%]
博茨瓦纳资源有限条件下实施宫颈癌微创手术的挑战——病例系列报告
Elizabeth Corn,Kelly Becht,Bethel Adefres et al.
Elizabeth Corn et al.
Purpose: Cervical cancer is the number one cause of cancer-related mortality for women in Botswana, where care is complicated by the country's severe shortage of gynecologic oncologists. Recent data suggests that "low-ris...