Data-driven age partitioning for pediatric serum copper: implications for reference interval interpretation [0.03%]
数据驱动的儿科血清铜年龄分组及其参考区间解释的启示
Hien Thu Pham,Minh Thi Huyen Nguyen,Quyen Hue Luong et al.
Hien Thu Pham et al.
Objectives: To establish age-specific reference intervals for serum copper in healthy Vietnamese children and adolescents using a data-driven age-partitioning approach and to assess its implications for result interpretat...
Drug-induced plasma discolouration mimicking icterus risks inappropriate withholding of critical lactate [0.03%]
药物引起的血浆变色与黄疸：避免关键乳酸误遗漏的风险
Briedgeen Kerr,Aine Murphy,Conal Houstoun et al.
Briedgeen Kerr et al.
A lactate concentration ≥4 mmol/L is associated with organ dysfunction and poor outcomes in sepsis, making accurate measurement and timely communication of critical results vital. Photometric lactate assays are common but prone to spectral...
Evaluation of the interference of 49 commonly used clinical drugs on 60 biochemical tests [0.03%]
常用临床药物对生化检测的干扰评估研究
Weiting Yu,Xiaochun Shu,Lian Wang et al.
Weiting Yu et al.
Objective: This study aimed to systematically evaluate the interference of 49 commonly used clinical drugs on 60 routine biochemical tests, providing a foundation for clinical laboratories to establish drug-interference a...
Maternal vaginal colonization screening for term singleton pregnancy: comparative evaluation of metagenomic next-generation sequencing (mNGS) versus real-time quantitative PCR (qPCR) [0.03%]
孕妇单胎妊娠阴道定植筛查：宏基因组高通量测序技术与实时荧光定量 PCR 的比较研究
Jinyu Zhang,Jingyi Liang,Fei Lv et al.
Jinyu Zhang et al.
Objective: To investigate the distribution characteristics of potential high-risk pathogens for early-onset neonatal infection in maternal vaginal secretions, and to perform a head-to-head comparative evaluation of detect...
A semi-automatization magnetic solid-phase extraction method of LC-MS/MS for the quantification of homocysteine and its related metabolites in serum [0.03%]
基于LC-MS/MS的同型半胱氨酸及其相关代谢物定量分析的半自动化磁固相提取方法
Zhicheng Ye,Xueding Han,Guanfeng Lin et al.
Zhicheng Ye et al.
Background: Clinical mass spectrometry is recognized for its high specificity and sensitivity in quantifying small-molecule biomarkers in serum. However, its broad adoption in clinical settings has been limited by challen...
Performance validation and clinical concordance of a novel fully automated immunoassay system for five tumor markers: A comparative study with an international reference platform [0.03%]
一种新型全自动五肿瘤标志物联检免疫分析系统的性能验证及临床符合性研究：与国际参考平台对比研究
Ruobing Wang,Jianmin Liu,Ting Cao et al.
Ruobing Wang et al.
Objective: The high cost of imported platforms limits widespread lung cancer risk stratification in resource-limited settings. Based on CLSI guidelines, this study aimed to conduct a preliminary analytical verification of...
Development and validation of a rule-based tool for quality management reporting in a genetics laboratory [0.03%]
遗传学实验室质量管理报告的规则基于工具的开发与验证
Fouad Trad,Jana Doghman,Sarah Sayegh et al.
Fouad Trad et al.
Introduction: Quality management systems are essential in clinical laboratories to ensure optimal operational output. However, report generation still frequently relies on manual processes which are time-consuming and pro...
Establishment of reference intervals for 41 serum biochemical analytes in healthy Chinese children [0.03%]
中国健康儿童生化参考区间的建立——41项生化指标参考区间报道
Qinlan Liu,Xiufa Zhang,Ling Zhuang et al.
Qinlan Liu et al.
Purpose: Owing to the absence of appropriate pediatric reference intervals (RIs), this study aimed to establish age-specific RIs for serum biochemical analytes in healthy Chinese children. ...
Analytical performance evaluation and method comparison of the 1copy BCR::ABL1 qPCR assay for monitoring chronic myeloid leukemia [0.03%]
用于监测慢性粒细胞白血病的1copy BCR::ABL1 qPCR检测试剂盒的性能评估及方法学比较
Hyerin Kim,Do Young Kim,Hyerim Kim
Hyerin Kim
Background: Accurate BCR::ABL1 quantification is essential for monitoring chronic myeloid leukemia (CML), particularly at the major molecular response (MMR; ≤0.1% IS) and deep molecular response (DMR) levels: MR4 (≤0.01...
Comparison of pre-analytical properties of blood collection systems for the diagnosis of diabetes mellitus [0.03%]
用于诊断糖尿病的血液采集系统的预分析性能比较
Juliane Flindt,Michael Radziewitz,Andreas Müller et al.
Juliane Flindt et al.
Background: Proper pre-analytical handling of blood samples is essential for reliable glucose measurement and for the accurate diagnosis and monitoring of diabetes mellitus. This study aimed to compare glucose concentrati...