A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function [0.03%]
横断面研究发现氧化应激途径基因型及其与环境污染物水平的相互作用与基因表达和肺功能相关性
Shuangjia Xue,Seyed Mehdi Nouraie,Jiebiao Wang et al.
Shuangjia Xue et al.
Background: Asthma is a heterogeneous disease influenced by genetic and environmental factors. Fine particulate matter (PM2.5) exacerbates asthma, likely through oxidative stress pathways, but whether genetic variation mo...
Global and regional DNA methylation patterns in heart failure: a case-control analysis [0.03%]
心力衰竭的全局和区域DNA甲基化模式：病例对照分析
Mykhailo Krolevets,Vincent Ten Cate,Jürgen H Prochaska et al.
Mykhailo Krolevets et al.
Background: Heart failure (HF) is a syndrome of heterogeneous aetiology and multiple exposomal causes. The role of DNA methylation (DNAm) changes in symptomatic HF and its phenotypes is unclear. This work addresses global...
The three-dimensional perspective of CAR-T cell therapy in autoimmune diseases [0.03%]
CAR-T细胞治疗自身免疫病的三维视角
Jiayi Shen,Jianhua Mao,Qing Ye
Jiayi Shen
Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in haematological malignancies, ushering in the era of adoptive cell therapy. In recent years, CAR-T cell therapy has been progressively explored in autoimmune...
Corrigendum to "Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study" [EBioMedicine 126(2026) 106224] [0.03%]
对“帕金森病患者血液微生物标志物的大规模谱型分析及其与疾病进展的关系：横断面研究”[EBioMedicine 126（2022）106224]的勘误通知
Xingxing Jian,Pei Yu,Yi Zhang et al.
Xingxing Jian et al.
Published Erratum
EBioMedicine. 2026 Jun 20:129:106346. DOI:10.1016/j.ebiom.2026.106346 2026
CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial [0.03%]
高剂量DHA补充对有痴呆风险老年人中枢神经系统靶点的作用：随机双盲安慰剂对照试验
Hussein N Yassine,Sara Ghasem Pour,Marlene Juarez et al.
Hussein N Yassine et al.
Background: APOE ε4 carriers have increased Alzheimer's disease risk and altered omega-3 metabolism. No large-scale prevention trials have tested high-dose docosahexaenoic acid (DHA) supplementation specifically in non-d...
A practical alternative to live cell-based assay for AQP4 and MOG antibody detection [0.03%]
一种实用的活细胞基质检测AQP4和MOG抗体的替代方法
Qi Wang,Feng Chen,Yuqi Tang et al.
Qi Wang et al.
Background: Live cell-based assay (LCBA) is the gold standard for sensitive detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in neuromyelitis optica spectrum disorder (NMOSD) an...
Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility [0.03%]
超声定位显微镜追踪男性不育患者的睾丸微血管适应内分泌功能变化
Nikoleta Papanikolaou,Jipeng Yan,Biao Huang et al.
Nikoleta Papanikolaou et al.
Background: Testicular disorders, including male infertility and hypogonadism, are increasingly prevalent and current diagnostic tools have important limitations. The testicular microcirculation underpins testicular funct...
Effects of sevasemten (EDG-5506) on safety, biomarkers, and functional measures in adults with Becker muscular dystrophy: results of a phase 1b, open-label study [0.03%]
塞瓦森特恩（EDG-5506）对贝克尔型肌营养不良症成人患者安全性、生物标志物和功能测量指标的影响：一项1b期开放标签研究的结果
Han Phan,Ben Barthel,Molly Madden et al.
Han Phan et al.
Background: Sevasemten (EDG-5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fibre contraction by inhibiting fast myosin ATPase. In animal models of Duchenne and Becke...
Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis [0.03%]
实验性关节炎和全身型幼年特发性关节炎小鼠海马神经炎症及外周神经生物学蛋白谱的改变
Xingzhao Wen,Heshuang Qu,Malgorzata Benedyk-Machaczka et al.
Xingzhao Wen et al.
Background: Children with juvenile idiopathic arthritis (JIA) are reported to exhibit increased rates of symptoms affecting emotional regulation and behaviour. However, underlying biological mechanisms remain unclear. Inf...
Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers [0.03%]
应用血浆和脑脊液生物标志物检测主观认知下降患者的淀粉样蛋白-β病理变化
José Contador,Federico Emanuele Pozzi,Gonzalo Sánchez-Benavides et al.
José Contador et al.
Background: Subjective cognitive decline (SCD) may represent an early stage of Alzheimer's disease (AD), but biomarker studies in this population are limited. Therefore, we compared the performance of a comprehensive pane...