Generation and characterisation of a humanised GLP-1 receptor mouse model for translational drug development [0.03%]
人源化GLP-1受体小鼠模型的构建及表征用于药物转化开发
Nina Sonne,Micaela Roque,Line Fisker Zachariassen et al.
Nina Sonne et al.
Background: Injectable peptide-based glucagon-like peptide-1 receptor (GLP1R) agonists (GLP1RAs) are effective treatments for obesity and diabetes but are limited by patient compliance and scalability challenges. In contr...
Broadening applications for intrathecal gene therapy: a case for lysosomal storage diseases [0.03%]
脑室内基因治疗的更广泛应用——以溶酶体贮积病为例
eBioMedicine
eBioMedicine
Plasma p-tau species are elevated in presymptomatic and symptomatic neuronal intranuclear inclusion disease [0.03%]
预症状和症状性神经细胞内包涵体病的血浆p-tau蛋白水平升高
Sizhe Zhang,Bin Jiao,Yan Zeng et al.
Sizhe Zhang et al.
Background: Neuronal intranuclear inclusion disease (NIID), caused by GGC repeat expansions in NOTCH2NLC, is a neurodegenerative disease frequently involved with cognitive impairment. Limited studies have focused on the b...
Cameron A B Smith,Harvey Wilson,Jipeng Yan et al.
Cameron A B Smith et al.
Super-resolution ultrasound, with its ability to achieve sub-diffraction resolution and directly track microvascular flow velocity in vivo, offers a level of vascular information inaccessible previously. To fully realise its clinical value,...
Optimal Spectrum Antibiotic Ratio for assessing antibiotic utilisation in sepsis caused by gram-negative bacilli [0.03%]
用于评估由革兰氏阴性杆菌引起的脓毒症中的抗生素使用的最适光谱抗生素比例
Reid Goodman,Alice Bewley,Andrew Atkinson et al.
Reid Goodman et al.
Background: Accurate monitoring of antimicrobial consumption is essential for developing effective stewardship interventions. Hospitals are mandated to report antibiotic treatment duration using the CDC's Standardized Ant...
Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure [0.03%]
遗传学解剖血清前神经营养素提示其可能对脑结构产生因果影响
Jana Breitfeld,Katrin Horn,Akhil Velluva et al.
Jana Breitfeld et al.
Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes li...
Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection [0.03%]
普乌马拉病毒的感染会产生能中和多种汉坦病毒的交叉反应性中和抗体
Jordan J Clark,Stefan Hatzl,Kirill Vasilev et al.
Jordan J Clark et al.
Background: Orthohantaviruses (hantaviruses) are emerging rodent-borne pathogens that can cause severe human disease. They are present on multiple continents and are responsible for thousands of human cases per year. Desp...
Real world deployment of a pancreatic cancer risk model: impact of refitting, imputation, and computational burden [0.03%]
胰腺癌风险预测模型的现实世界部署：重新拟合、插补和计算量的影响分析
Wansu Chen,Botao Zhou,Tiffany Q Luong et al.
Wansu Chen et al.
Background: Early detection is a major clinical challenge in pancreatic cancer due to its nonspecific symptoms and frequent late-stage diagnosis. While predictive models using electronic health record (EHR) data show prom...
The circulating proteome and cancer risk: a systematic literature review and meta-analysis of 26 prospective studies with genetic validation [0.03%]
循环蛋白质组与癌症风险：一项包含26项前瞻性研究的系统文献回顾及遗传验证的荟萃分析
Alison Dillman,Haige An,Zhe Huang et al.
Alison Dillman et al.
Background: Proteins have an integral role in cancer aetiology and inform cancer detection, treatment, and prognosis. While published data from prospective proteomic studies identifying early detection cancer risk markers...