Factors associated with severe COVID-19 in immunocompromised subgroups in England from 2020 to 2024: an OpenSAFELY cohort study [0.03%]
英国2020年至2024年免疫抑制亚群中严重COVID-19的相关因素：一项OpenSAFELY队列研究
Edward P K Parker,Thomas Hartney,Linda Nab et al.
Edward P K Parker et al.
Background: Individuals with compromised immune systems are particularly vulnerable to COVID-19. Although several studies have assessed factors associated with COVID-19-related hospitalisation and mortality in the general...
Intrapartum caesarean delivery and childhood BMI trajectories in relation to the infant gut microbiome in the VDAART prospective birth cohort [0.03%]
分娩方式与早期儿童BMI变化轨迹及婴儿肠道菌群的关系——VDAART前瞻性生儿队列研究
Zheng Sun,Tong Wang,Jessica A Lasky-Su et al.
Zheng Sun et al.
Background: The rising global health crisis of childhood overweight and obesity is potentially influenced by caesarean delivery (CD), but it remains a subject of ongoing debate. The gut microbiome, which is affected by de...
Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis [0.03%]
泛癌基因组结构方程模型鉴定出一个潜在的癌症易感因子及致癌共有决定因素
Qian Xu,Lu Niu,Zian Cao et al.
Qian Xu et al.
Background: Common cancers share germline susceptibility, yet the genetic architecture of a truly pan-cancer component of carcinogenesis remains incompletely resolved. ...
Blood DNA methylation and breast cancer risk: a prospective nested case-control study [0.03%]
基于嵌套病例对照研究的血液DNA甲基化与乳腺癌发病风险的相关性分析
Juan Rodriguez,Felix Grassmann,Damien Kaukonen et al.
Juan Rodriguez et al.
Background: Blood tests that predict breast cancer (BC) risk before diagnosis could complement mammography screening. Whole-blood DNA methylation is stable and may capture early systemic changes related to tumour developm...
Lipidomic signatures in gestational diabetes mellitus and postpartum type 2 diabetes mellitus: a narrative review of etiologic and predictive implications [0.03%]
妊娠期糖尿病和产后2型糖尿病的脂质组学标志物：病因学及预测意义的叙事性综述
Shenrui Zhang,Xindi Jiang,Shixuan Zhang et al.
Shenrui Zhang et al.
Gestational diabetes mellitus (GDM) represents one of the most common complications of pregnancy, with a steadily increasing global prevalence. It serves as an independent risk factor for adverse pregnancy outcomes and confers long-term hea...
A multi-centre, phase 1a/1b dose escalation and expansion study of the HER2-directed antibody-drug conjugate T-Bren (BL-M07D1) in advanced breast cancer and other solid tumours [0.03%]
一种针对HER2的抗体药物偶联物T-Bren（BL-M07D1）在晚期乳腺癌和其他实体瘤中进行剂量递增和扩展的多中心一期a/一期b期研究
Herui Yao,Ruihua Zhao,Xiuping Lai et al.
Herui Yao et al.
Background: Trastuzumab brengitecan (T-Bren; BL-M07D1) is a HER2-directed antibody-drug conjugate (ADC) comprising a monoclonal antibody, a cathepsin B-cleavable linker, and a potent topoisomerase I inhibitor payload (Ed-...
Effectiveness of baloxavir marboxil in nonhuman primates infected with highly pathogenic avian influenza A(H7N9) virus [0.03%]
baloxavir marboxil用于感染高致病性人禽流感H7N9病毒灵长类动物的有效性研究
Kiyoko Iwatsuki-Horimoto,Masaki Imai,Toru Ishibashi et al.
Kiyoko Iwatsuki-Horimoto et al.
Background: Highly pathogenic avian influenza (HPAI) A(H7N9) virus poses a potential public health threat, underscoring the need for effective antiviral options for outbreak preparedness. Baloxavir marboxil (BXM) is a cap...
Empowering digital health management with on-device large language models for glucose prediction: a model development and validation study [0.03%]
基于设备的大规模语言模型赋能的数字健康管理模式在血糖预测中的开发和验证研究
Taiyu Zhu,Joanna Howson,Alejo Nevado-Holgado
Taiyu Zhu
Background: Long-term management of chronic diseases such as diabetes is increasingly based on wearable technologies, particularly continuous glucose monitoring (CGM), integrated with smartphone-based digital health syste...
Serum inflammatory proteomic signatures define chronic inflammatory demyelinating polyneuropathy and inform on disease activity [0.03%]
血清炎症蛋白组特征可定义慢性炎性脱髓鞘多发性神经病并提供疾病活动信息
Amol Keshavasa Bhandage,Frauke Stascheit,Hannah Preßler et al.
Amol Keshavasa Bhandage et al.
Background: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune-mediated neuropathy with heterogeneous presentation and variable treatment response. Blood-based biomarkers remain lacking, and interpretat...
Adverse and adaptive placental DNA methylation changes linking prenatal air pollution exposure to child lung function: findings from the SEPAGES cohort [0.03%]
孕期接触空气污染通过影响胎盘DNA甲基化而对儿童肺功能产生不利及适应性改变的机制研究——来自法国孕妇和新生婴儿队列（SEPAGES）的证据
Lucile Broséus,Valérie Siroux,Gaëlle Uzu et al.
Lucile Broséus et al.
Background: Prenatal air pollution exposure (PAPE) may have programming effects on offspring health. Placental epigenetic modifications are hypothesised to mediate this relationship, but evidence remains limited. We inves...