Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure [0.03%]
遗传学解剖血清前神经营养素提示其可能对脑结构产生因果影响
Jana Breitfeld,Katrin Horn,Akhil Velluva et al.
Jana Breitfeld et al.
Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes li...
Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection [0.03%]
普乌马拉病毒的感染会产生能中和多种汉坦病毒的交叉反应性中和抗体
Jordan J Clark,Stefan Hatzl,Kirill Vasilev et al.
Jordan J Clark et al.
Background: Orthohantaviruses (hantaviruses) are emerging rodent-borne pathogens that can cause severe human disease. They are present on multiple continents and are responsible for thousands of human cases per year. Desp...
Real world deployment of a pancreatic cancer risk model: impact of refitting, imputation, and computational burden [0.03%]
胰腺癌风险预测模型的现实世界部署：重新拟合、插补和计算量的影响分析
Wansu Chen,Botao Zhou,Tiffany Q Luong et al.
Wansu Chen et al.
Background: Early detection is a major clinical challenge in pancreatic cancer due to its nonspecific symptoms and frequent late-stage diagnosis. While predictive models using electronic health record (EHR) data show prom...
The circulating proteome and cancer risk: a systematic literature review and meta-analysis of 26 prospective studies with genetic validation [0.03%]
循环蛋白质组与癌症风险：一项包含26项前瞻性研究的系统文献回顾及遗传验证的荟萃分析
Alison Dillman,Haige An,Zhe Huang et al.
Alison Dillman et al.
Background: Proteins have an integral role in cancer aetiology and inform cancer detection, treatment, and prognosis. While published data from prospective proteomic studies identifying early detection cancer risk markers...
Tirzepatide reduces alcohol drinking and relapse-like behaviours in rodents [0.03%]
Tirzepatide减少啮鼠的饮酒和类似复发的行为
Christian E Edvardsson,Louise Adermark,Sam Gottlieb et al.
Christian E Edvardsson et al.
Background: Alcohol use disorder (AUD) remains a major public health problem, with few effective medications currently available. However, peptides of the gut-brain axis appear to offer promising therapeutic targets for A...
Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity [0.03%]
多组学研究识别出氧化应激、促凝血途径和乳过氧化物酶变异为影响新冠肺炎严重性的关键因素
Claudio Cappadona,Valeria Rimoldi,Francesca Tettamanzi et al.
Claudio Cappadona et al.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected over 26 million individuals in Italy, resulting in ∼200,000 COVID-19-related deaths. Unravelling host genetic factors underlying disease s...
Loss of function variants in the primate-specific gene ZNF808 cause neonatal, transient and adult-onset diabetes [0.03%]
功能变异丢失的灵长类特异性基因ZNF808导致新生儿、暂时性和成人发病型糖尿病
James Russ-Silsby,Kevin Colclough,Matthew B Johnson et al.
James Russ-Silsby et al.
Background: Biallelic loss-of-function ZNF808 variants were recently identified as a cause of pancreatic agenesis characterised by insulin-treated permanent neonatal diabetes (PNDM), low birthweight and exocrine pancreati...
Renal podocyte senescence in human obesity detected by urinary extracellular vesicles [0.03%]
人肥胖患者尿液细胞外囊泡检测到肾系膜细胞衰老
Lei Zhang,Mina Al-Saeedi,Aleksandar Denic et al.
Lei Zhang et al.
Background: Obesity is a major risk factor for kidney dysfunction, with cellular senescence and senescence-associated secretory phenotype (SASP) activation contributing to early kidney injury. Urinary extracellular vesicl...
Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders [0.03%]
儿童脑脊液免疫组化鉴别诊断儿童期发病多发性硬化和其他儿童急性神经疾病
Diego A Espinoza,Tobias Zrzavy,Gautier Breville et al.
Diego A Espinoza et al.
Background: The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as i...
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset [0.03%]
新冠发病前后新冠疫情下必要工作人员的神经后遗症与磷酸化tau蛋白(pTau-181)增加有关：一项前瞻性队列研究
Xiaohua Yang,Ashley Fontana,Sean A P Clouston et al.
Xiaohua Yang et al.
Background: The COVID-19 pandemic led to a spectrum of post-acute sequelae including several neurological complications including cognitive dysfunction labelled Neurological PASC (N-PASC). We hypothesised that N-PASC was ...