Senloytics, dasatinib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease [0.03%]
Senloytics（dasatinib联合白藜芦醇）可减轻肾脏炎症、衰老细胞数量和损伤，同时恢复小鼠糖尿病肾病的抗衰老因素
Xiaohui Bian,Zachary K Snow,Caroline J Zinn et al.
Xiaohui Bian et al.
Background: Maladaptive inflammation and cellular senescence contribute to diabetic kidney disease (DKD) pathogenesis and represent important therapeutic targets. Senolytic agents selectively remove senescent cells and re...
Fuzzy classification of sepsis subtypes and implications for trajectory and treatment [0.03%]
脓毒症亚型的模糊分类及其对预后和治疗的影响
Jason N Kennedy,Stuthi Iyer,Peter C Nauka et al.
Jason N Kennedy et al.
Background: Sepsis is common and deadly, and subtypes are proposed to guide precision treatment. However, little is known about the uncertainty in subtype classification, and its implications for trajectory and treatment ...
Owen Carmichael
Owen Carmichael
A nanobody-stem cell platform targeting innate and adaptive immune axis in the tumour microenvironment [0.03%]
针对肿瘤微环境固有和适应性免疫轴的纳米抗体-干细胞平台技术
Ioulia Vogiatzi,Amelia Lehmann,Chuang Liu et al.
Ioulia Vogiatzi et al.
Background: Tumour associated macrophages (TAMs) and exhausted T cells are dominant in the immuno-suppressive tumour microenvironment (TME) and pose a challenge to effective cancer immunotherapy in solid tumours. ...
Generation and characterisation of a humanised GLP-1 receptor mouse model for translational drug development [0.03%]
人源化GLP-1受体小鼠模型的构建及表征用于药物转化开发
Nina Sonne,Micaela Roque,Line Fisker Zachariassen et al.
Nina Sonne et al.
Background: Injectable peptide-based glucagon-like peptide-1 receptor (GLP1R) agonists (GLP1RAs) are effective treatments for obesity and diabetes but are limited by patient compliance and scalability challenges. In contr...
Broadening applications for intrathecal gene therapy: a case for lysosomal storage diseases [0.03%]
脑室内基因治疗的更广泛应用——以溶酶体贮积病为例
eBioMedicine
eBioMedicine
Plasma p-tau species are elevated in presymptomatic and symptomatic neuronal intranuclear inclusion disease [0.03%]
预症状和症状性神经细胞内包涵体病的血浆p-tau蛋白水平升高
Sizhe Zhang,Bin Jiao,Yan Zeng et al.
Sizhe Zhang et al.
Background: Neuronal intranuclear inclusion disease (NIID), caused by GGC repeat expansions in NOTCH2NLC, is a neurodegenerative disease frequently involved with cognitive impairment. Limited studies have focused on the b...
Cameron A B Smith,Harvey Wilson,Jipeng Yan et al.
Cameron A B Smith et al.
Super-resolution ultrasound, with its ability to achieve sub-diffraction resolution and directly track microvascular flow velocity in vivo, offers a level of vascular information inaccessible previously. To fully realise its clinical value,...
Optimal Spectrum Antibiotic Ratio for assessing antibiotic utilisation in sepsis caused by gram-negative bacilli [0.03%]
用于评估由革兰氏阴性杆菌引起的脓毒症中的抗生素使用的最适光谱抗生素比例
Reid Goodman,Alice Bewley,Andrew Atkinson et al.
Reid Goodman et al.
Background: Accurate monitoring of antimicrobial consumption is essential for developing effective stewardship interventions. Hospitals are mandated to report antibiotic treatment duration using the CDC's Standardized Ant...