Multi-modal single-cell sequencing reveals network transition in circulating monocytes that aligns with faster recovery in patients with trauma and favours a response to M-CSF [0.03%]
多模态单细胞测序揭示了循环单核细胞中的网络转换，与创伤患者的快速恢复一致并有利于M-CSF的反应
Tianmeng Chen,Julia Hughes,Julia Cornoy et al.
Tianmeng Chen et al.
Background: Previous transcriptomic studies demonstrated an acute genomic storm in circulating immune cells after trauma that gradually returns to baseline. The magnitude and duration of these changes is associated with p...
HCV-specific CD4+ T-cells are susceptible to HIV-1 and contribute to viral persistence during antiretroviral therapy [0.03%]
人类免疫缺陷病毒(HIV)可感染丙型肝炎病毒(HCV)特异性辅助性T细胞并导致其持续存在及功能障碍
Samaa T Gobran,Armando Espinosa Ortiz,Omar Khedr et al.
Samaa T Gobran et al.
Background: Antiretroviral therapy (ART) reduces human immunodeficiency virus type 1 (HIV-1) replication to undetectable levels but does not eliminate HIV-1 reservoirs, which persist in memory CD4+ T-cells of various anti...
Effects of exercise and exercise timing on energy intake and appetite control: a randomised crossover trial in people with overweight or obesity with and without type 2 diabetes [0.03%]
运动与运动时间对超重或肥胖且患有或未患2型糖尿病的人的能量摄入和摄食行为的影响：随机交叉试验
Natja Poder Launbo,Lea Jalking,Marie Møller Jensen et al.
Natja Poder Launbo et al.
Background: This randomised crossover trial (ClinicalTrials.gov: NCT05768958) examined how high-intensity interval exercise (HIIE) vs. rest and time of day affect ad libitum energy intake, subjective appetite, and metabol...
Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates [0.03%]
一种针对SARS-CoV-2的新型CD40特异性疫苗在非人灵长类动物中的免疫原性和保护效力研究
Romain Marlin,Mireille Centlivre,Laetitia Bossevot et al.
Romain Marlin et al.
Background: The emergence of antigenically distinct SARS-CoV-2 variants increases the risk of immune escape and requires continually updated vaccines. In addition, short-lived specific immunity is a limitation faced by cu...
The role of mucosal IgA in protection against influenza A H1N1 virus infection in a real-world setting [0.03%]
黏膜IgA在抵抗甲型H1N1流感病毒真实世界场景下的作用研究
Oscar Bladh,Tamás Pongrácz,Katherina Aguilera et al.
Oscar Bladh et al.
Background: Parenteral vaccines against influenza virus prevent severe disease but provide limited protection against infection, likely due to limited induction of mucosal immunity. However, direct clinical evidence for m...
Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study [0.03%]
美国婴儿早期肠道微生物组组成与轮状病毒疫苗诱导的IgA反应：一项纵向队列研究
Janiret Narváez-Miranda,Michael B Sohn,Daniel Velasquez-Portocarrero et al.
Janiret Narváez-Miranda et al.
Background: Rotavirus remains a leading cause of childhood mortality worldwide, despite the widespread introduction of oral rotavirus vaccines. Evidence linking the gut microbiome to vaccine response is inconsistent and l...
Endogenous neuroprotection in vascular cognitive impairment and dementia [0.03%]
血管性认知障碍和痴呆的内源性神经保护作用
Chunyan Li,Willians Tambo,Keren Powell et al.
Chunyan Li et al.
Vascular cognitive impairment and dementia (VCID), affecting millions globally with 30% higher mortality than Alzheimer's disease, lacks effective pharmacotherapies. Microvascular dysfunction emerges decades before clinical symptoms, drivin...
Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features [0.03%]
在扭转痉挛中的三联体分析鉴定出新颖的KLC1变异基因型并确定其运动和神经发育特征具有区分度的客运素病变式
Elisa Peirano,Laura O&#x;Regan,Philip Harrer et al.
Elisa Peirano et al.
Background: Although de novo causation in dystonia is widely acknowledged, there have been only a few trio-sequencing analyses in this field. We sought to prioritise de novo variants in dystonia and characterise the clini...
A preS2 aa1-26-specific humoural response marks functional cure in chronic HBV infection [0.03%]
慢性乙肝感染功能治愈的标志是针对preS2 aa1-26的体液反应阳性
You-Yuan Wang,Jun-Liang Fu,Wen-Xin Wang et al.
You-Yuan Wang et al.
Background: Functional cure (FC) of chronic hepatitis B (CHB) is closely associated with restoration of HBV-specific humoural immunity, yet the epitope-resolved features of humoural immunity recovery during interferon-ind...
Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis [0.03%]
扰动的代谢适应与人类败血症住院期间天然杀伤细胞功能障碍和医院内感染相关
André van der Wurff,Monika Gambusz,Bettina Budeus et al.
André van der Wurff et al.
Background: Patients with sepsis are highly susceptible to detrimental nosocomial infections. During bacterial infection, natural killer (NK) cells release Interferon (IFN) γ that drives the elimination of invading patho...