Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms [0.03%]
长新冠患者的纹状体单胺转运蛋白2丢失及其与神经精神症状的关系
Yuhan Karida Liu,Devina Persaud,Erica L Vieira et al.
Yuhan Karida Liu et al.
Background: Dopaminergic neurons are vulnerable to injury from gliosis and have high density of ACE2 receptors, but the integrity of dopaminergic neurons has not been investigated in long COVID. This study examined whethe...
Dopaminergic vulnerability in long COVID: striatal PET imaging at the brain-body interface [0.03%]
长新冠患者的多巴胺能脆弱性：脑-身体界面的纹状体正电子发射断层扫描影像学研究
Eric Guedj,Danielle Beckman
Eric Guedj
Off-label testosterone therapy is associated with higher long-term cardiovascular risk in men [0.03%]
男性非适应症使用睾丸激素治疗与长期心血管风险增加有关
Hatim Kerniss,Philip Curman,Henning Olbrich et al.
Hatim Kerniss et al.
Background: Testosterone therapy (TT) is increasingly initiated outside classical hypogonadism, but long-term cardiovascular safety in this context remains uncertain. We assessed whether TT initiation without evidence of ...
Brainwaves under medication: revealing class-specific neural signatures of psychotropic medication from 24,000 EEGs [0.03%]
药物作用下的脑电波：从24000份脑电图中揭示精神活性药物的特定神经特征signature
Magdalena Szponar,Patrycja Dzianok,Bartłomiej Gmaj et al.
Magdalena Szponar et al.
Background: Psychotropic medications remain foundational in psychiatric care, yet the neurophysiological mechanisms through which they exert therapeutic and adverse effects are still poorly characterised, limiting the fie...
Serum aromatic l-amino acid decarboxylase activity as a biomarker for prodromal and manifest Parkinson's disease [0.03%]
血清芳香族L-氨基酸脱羧酶活性作为帕金森病前驱期和明确期的生物标志物
Milan Beckers,Iris Kersten,Lukas Pavelka et al.
Milan Beckers et al.
Background: Aromatic l-amino acid decarboxylase (AADC), or dopa decarboxylase (DDC), is a key enzyme in levodopa metabolism. Previous studies suggested that AADC protein levels may be increased in Parkinson's disease (PD)...
Decoding the host-microbiome dialogue with biological foundation models [0.03%]
基于生物基础模型的宿主-微生物组对话解码
eBioMedicine
eBioMedicine
Transcriptomics of type 1 diabetes progression: a validation study in newly diagnosed patients [0.03%]
一项针对新诊断糖尿病患者的1型糖尿病发病进程转录组学研究
Tomi Suomi,Inna Starskaia,Omid Rasool et al.
Tomi Suomi et al.
Background: Type 1 diabetes is an autoimmune disease with significant long-term complications. Variability in the decline of insulin secretion after diagnosis complicates both the development of treatments and disease man...
Linking maternal blood pressure with fetal cerebral haemodynamics and cortical growth in congenital heart disease [0.03%]
先天性心脏病孕妇血压与胎儿脑血流及皮层生长的关系分析
Siân Wilson,Seungyoon Jeong,Louise Wilkins-Haug et al.
Siân Wilson et al.
Background: Children with congenital heart disease (CHD) experience neurodevelopmental challenges, arising in part from altered brain maturation beginning in utero. There are currently no prenatal interventions to mitigat...
P2Y12-P-selectin-mediated platelet activation in a murine model of dengue-associated thrombocytopenia [0.03%]
登革相关血小板减少小鼠模型中P2Y12-P-选择素介导的血小板活化作用机制研究
Viviane Lima Batista,Jenniffer Ramos Martins,Angélica Samer Lallo Dias et al.
Viviane Lima Batista et al.
Background: Dengue virus (DENV) infection frequently leads to thrombocytopenia, a hallmark of severe disease. However, the underlying mechanisms remain incompletely defined. Therefore, this study aimed to investigate the ...
Inosine accumulation in hydrosalpinx fluid: a metabolic barrier to early embryonic development [0.03%]
积液中次黄嘌呤累积：胚胎早期发育的代谢屏障
Yin-Li Zhang,Xiaomei Tong,Songying Zhang
Yin-Li Zhang