Precision oncology in adjuvant aspirin therapy for colorectal cancer: emerging genetic markers and persistent uncertainties [0.03%]
精准肿瘤学在结直肠癌术后阿司匹林治疗中的应用：新兴的遗传标志物与持续存在的不确定性
Paola Patrignani,Sara Di Berardino,Stefania Tacconelli
Paola Patrignani
Individualised treatment effects of corticosteroids in IgA nephropathy [0.03%]
肾病综合征个体化糖皮质激素治疗效果研究进展
David L Hölscher,Nikolas E J Schmitz,Leon Niggemeier et al.
David L Hölscher et al.
Background: IgA nephropathy (IgAN) has diverse clinical presentations and responses to treatment. For systemic corticosteroids in particular, randomised controlled trials have reported conflicting effects, highlighting th...
Metabolomic signatures for diagnosis and clinical severity in Parkinson's disease [0.03%]
帕金森病的诊断和临床严重程度的代谢标志物
Yige Wang,Yaqin Xiang,Xiurong Huang et al.
Yige Wang et al.
Background: Parkinson's disease (PD) remains challenging to diagnose at early stages owing to subtle and heterogeneous clinical manifestations and the lack of reliable biomarkers. Metabolomics offers a powerful approach t...
Perilymphatic ATP plays a critical role in modulating cochlear function to protect from loud sound induced hearing loss [0.03%]
顶浆ATP在调节耳蜗功能以防止大声引起的听力损失方面起着关键作用
Sonal Prasad,Urban Karlsson,Marja Pitkänen et al.
Sonal Prasad et al.
Background: Extracellular adenosine triphosphate (ATP) signalling via purinergic receptors plays a key role in cochlear adaptation to loud sound. Traditionally, ATP activation of purinergic receptor P2X receptors has been...
Serum metabolomics profiling in head and neck squamous cell carcinoma: a multicentre diagnostic study [0.03%]
头颈部鳞状细胞癌血清代谢组学诊断标志物的多中心研究
Hexin Ma,Xinran Zhao,Zhihui Li et al.
Hexin Ma et al.
Background: Head and neck squamous cell carcinoma (HNSCC) is frequently diagnosed at advanced stages, when outcomes are poor. Biomarkers for HNSCC detection remain needed. ...
CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum [0.03%]
Down综合征-阿尔茨海默病连续体中的脑脊液和血浆tau标志物
Javier Arranz,Juan Lantero-Rodríguez,Luisa Sophie Braun-Wohlfahrt et al.
Javier Arranz et al.
Background: Nearly all individuals with Down syndrome (DS) develop Alzheimer's disease (AD) dementia, primarily due to overexpression of the APP gene. Although specific cerebrospinal fluid (CSF) and plasma tau biomarkers ...
Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock [0.03%]
整合免疫和内皮细胞谱预测术后脓毒症和脓毒性休克90天死亡率
Rosa Dolores Prieto-Utrera,Miguel Bardají-Carrillo,Esther Gómez-Sánchez et al.
Rosa Dolores Prieto-Utrera et al.
Background: Sepsis and septic shock remain major causes of mortality in critically ill postoperative patients, largely because of the lack of reliable biomarkers for early risk stratification. The interplay between immune...
Corrigendum to "A next-generation probiotic strain for gut health: Bacteroides cellulosilyticus LYH2 variant with anti-inflammatory and metabolic advantages" [EBioMedicine 126 (2026) 106232] [0.03%]
关于“一种用于肠道健康的下一代益生菌菌株：具有抗炎和代谢优势的Bacteroides cellulosilyticus LYH2变体”一文的勘误(106232)[EBioMedicine 126 (2026)]
Cong Lan,Xiaofeng Deng,Shen Jin et al.
Cong Lan et al.
Published Erratum
EBioMedicine. 2026 Jul 11:130:106378. DOI:10.1016/j.ebiom.2026.106378 2026
Clinical phenotyping of asthma patients with elevated sputum eosinophils and low blood eosinophils: a post-hoc analysis of the multicentre ATLANTIS cohort [0.03%]
基于ATLANTIS多中心队列的回顾性分析：血嗜酸性粒细胞水平正常而痰液嗜酸性粒细胞增高的哮喘患者的临床表型特征分析
Pauline J M Kuks,Atheer M A Aabed,Lauren C A Premereur et al.
Pauline J M Kuks et al.
Background: Patients with eosinophilic asthma are responsive to treatment with corticosteroids and biologics. Eosinophilia is usually identified based on blood eosinophil counts, but there is discordance between blood and...
Immunology of pregnancy and sepsis: shared and specific pathways guiding future precision care [0.03%]
妊娠和脓毒症的免疫学：指引未来精准治疗的共性和特异性通路
Harindra E Amarasinghe,Julian C Knight,Marian Knight
Harindra E Amarasinghe
Maternal sepsis remains a leading cause of preventable death globally, yet its underlying biology within the context of pregnancy is poorly understood. This review examines the extent to which pregnancy and sepsis share physiological, immun...