Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models [0.03%]
基于细胞因子mRNA的治疗可缓解树突状细胞和T细胞缺乏以消除小鼠模型中的侵袭性胰腺癌
Yoshiaki Tanji,Shu Shimada,Megumi Kato et al.
Yoshiaki Tanji et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) with peritoneal dissemination is highly refractory to chemotherapy and immunotherapy, leading to poor prognosis. We aimed to develop an innovative therapeutic approach f...
Oral delivery of GLP-1 analogues by recombinant Lactococcus lactis restores pancreatic islet structure through intestinal mucosal absorption in diabetic mice [0.03%]
重组乳酸乳球菌递送胰高血糖素样肽-1类似物修复糖尿病小鼠的肠粘膜吸收及其口服治疗作用
Yuanjian Huang,Xuancai Lin,Min Deng et al.
Yuanjian Huang et al.
Background: The oral delivery of native glucagon like peptide-1 (GLP-1) using recombinant probiotics has shown hypoglycaemic effects and glucose tolerance improvement in diabetic mice. However, the pharmacological mechani...
Kim Hei-Man Chow,Ted Abel
Kim Hei-Man Chow
Alzheimer's disease-related dementia (ADRD) is a progressive neurodegenerative condition characterised by cognitive decline and overlapping pathological features. Despite advances in diagnostic tools and therapies, challenges persist due to...
Autoencoders reveal polyunsaturated fatty acids (PUFA)-Related metabolic signature linked to cancer risk [0.03%]
自编码器揭示与癌症风险相关的多不饱和脂肪酸代谢特征
Marie Breeur,Joshua Atkins,Laia Peruchet-Noray et al.
Marie Breeur et al.
Background: Metabolomics is a valuable tool for characterising biological mechanisms involved in cancer development, but produces complex datasets with intricate interdependencies. While linear dimension reduction techniq...
Analysis of the Genome Aggregation Database (gnomAD) reveals a global burden of cystic fibrosis and the need for improved diagnosis and care [0.03%]
对基因组聚合数据库(gnomAD)的分析揭示了囊性纤维化的全球疾病负担及改善诊断和治疗的需求
Lilly Bar,Rebecca J Darrah,Sriram Vaidyanathan
Lilly Bar
Background: The presence of cystic fibrosis (CF) in diverse groups is known but its incidence is not established in non-European populations. We predict that the number of births with CF in populations with non-European a...
A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response [0.03%]
一种使用脱细胞腹膜基质的三维卵巢癌转移模型以研究治疗反应
Christiane Helgestad Gjerde,Katrin Kleinmanns,Anika Langer et al.
Christiane Helgestad Gjerde et al.
Background: High-grade serous ovarian carcinoma (HGSOC) presents a significant therapeutic challenge. Late-stage disease is frequently associated with peritoneal carcinomatosis. The peritoneal metastases exhibit a unique ...
Letter in response to "Kappa free light chain index as a substitute to oligoclonal bands in diagnosing multiple sclerosis" [0.03%]
关于「用κ轻链指数代替寡克隆带诊断多发性硬化」一文的来信
Florian Deisenhammer,Harald Hegen
Florian Deisenhammer
CFTR modulators partially restore the epithelial interferome in Aspergillus infection to improve clinical outcome [0.03%]
CFTR调节剂可部分恢复曲霉感染中的上皮细胞干扰素信号通路以改善临床转归
Sarah L Laverty,Imogen Felton,Michelle Casey et al.
Sarah L Laverty et al.
Background: The impact of CFTR modulator therapy on host immunity and outcomes in people with Cystic Fibrosis (CF)-related Aspergillus lung disease is poorly defined. We aimed to characterise fungal-relevant clinical outc...
Catherine A Taylor,Philippa May,Thomas J Stone et al.
Catherine A Taylor et al.
Background: Neuroblastoma and Wilms tumour (WT) are common childhood embryonal malignancies. Germline 2p24 duplication has been reported in several cases of neuroblastoma and WT, either as part of a larger 2p duplication ...
The post-exit infectious period in practice: implications for measles outbreak contact tracing [0.03%]
实际中的退出后的感染期：对麻疹暴发接触者追踪的启示
Nicolas Roydon Smoll
Nicolas Roydon Smoll