Harnessing metabolomics and proteomics in a clinical trial for pulmonary arterial hypertension: insights from post-hoc analysis of the REHAB-PH trial [0.03%]
代谢组学和蛋白质组学在肺动脉高压临床试验中的应用：来自REHAB-PH试验事后分析的启示
Hongyang Pi,Lu Xia,Samuel G Rayner et al.
Hongyang Pi et al.
Background: The significant clinical and molecular heterogeneity of pulmonary arterial hypertension (PAH) poses challenges in identifying effective therapies. Advanced multidimensional profiling offers an opportunity to c...
Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term [0.03%]
孕产妇的阿片类药物使用障碍和丙型肝炎病毒感染重塑了妊娠晚期外周免疫环境
Brianna M Doratt,Heather E True,Sheridan B Wagner et al.
Brianna M Doratt et al.
Background: Pregnancy requires precisely timed immune adaptations to maintain foetal tolerance while enabling timely initiation of labour, a process often conceptualised as the 'immune clock' of pregnancy. Disruption of t...
The landscape of gene mutations in a cohort of 3353 Han Chinese children with nonsyndromic hearing loss [0.03%]
汉族非综合征听力损失患儿基因突变图谱分析
Yun Xiao,Lei Chen,Yuechen Han et al.
Yun Xiao et al.
Background: Genetic diagnosis plays a critical role in enhancing the identification and clinical management of pediatric hearing loss, ultimately improving both physiological outcomes and social-emotional development. As ...
Testing the performance of polygenic scores for multiple traits to explain cerebral palsy in two independent cohorts [0.03%]
在两个独立队列中检验多性状多基因评分解释脑瘫表现性能的效果
Jodi T Thomas,Alexander S F Berry,Matthew T Oetjens et al.
Jodi T Thomas et al.
Background: Cerebral palsy (CP) is a complex neurodevelopmental disorder with both environmental and genetic contributors. Rare genetic variants explain a substantial proportion of CP, but the contribution of common varia...
Shared genetic architecture between sleep traits and cardiometabolic diseases [0.03%]
睡眠特征与心血管代谢疾病之间的共享遗传结构
Yuan Zhang,Shijie Jian,Haiyan Ouyang et al.
Yuan Zhang et al.
Background: Sleep traits, including sleep apnoea (SA), insomnia, daytime sleepiness, and snoring, frequently co-occur with cardiometabolic diseases (CMDs), with shared genetic factors suspected to underlie these associati...
Antigen-presenting neutrophils link streptococcal infection to adaptive immune activation in guttate psoriasis [0.03%]
呈抗原的中性粒细胞可将链球菌感染与银屑病点滴型的适应性免疫活化相联系
Arpita Das,Tsong-Long Hwang
Arpita Das
Accurate, fair, and generalisable scaling of injury severity score-based AI with demographics in terms of mortality in patients with trauma: multi-centre, multi-national retrospective cohort study [0.03%]
基于人群统计信息的创伤死亡率的AI模型的准确、公平和泛化的损伤严重程度评分标度：多中心、多国回顾性队列研究
Yunjeong Choi,Junepill Seok,Thomas Young-Chul Oh et al.
Yunjeong Choi et al.
Background: Accurate and equitable prediction of trauma-related in-hospital mortality is critical for guiding clinical decisions and optimising trauma care resources. Traditional severity scoring systems like the Injury S...
Filling the treatment gaps in osteoporosis: osteoimmunology as a new frontier [0.03%]
填补骨质疏松症治疗空白：骨免疫学作为新的前沿阵地
eBioMedicine
eBioMedicine
Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks [0.03%]
非脊髓灰质炎肠道病毒对人诱导多能干细胞来源神经网络电生理特性的影响
Feline F W Benavides,Syriam Sooksawasdi Na Ayudhya,Ashley K Pereirinha da Silva et al.
Feline F W Benavides et al.
Background: The non-polio enteroviruses (NPEV) enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71) are highly prevalent and considered pathogens of increasing health concern due to their neurotropic potential. Severe ne...
Integrating explainable AI and One Health: a new frontier in combating infectious diseases [0.03%]
可解释的人工智能与健康一体观：防治传染病的新前沿
Yanni Cao,Emma Lancaster,Jiyoung Lee et al.
Yanni Cao et al.
Infectious diseases (IDs) remain a major threat to global health and societal stability. Because most emerging IDs in humans are zoonotic in origin and shaped by environmental contexts, effective prevention and control call for a One Health...