GnRH-receptor antagonism as a targeted approach to reproductive dysfunction in polycystic ovary syndrome [0.03%]
GnRH受体拮抗剂在多囊卵巢综合征生殖功能障碍治疗中的作用
Ludovica Cotellessa,Hélène Maitre,Frank Giton et al.
Ludovica Cotellessa et al.
Background: Polycystic ovary syndrome (PCOS), recently renamed polyendocrine metabolic ovarian syndrome (PMOS), is characterised by neuroendocrine dysfunction with accelerated gonadotrophin-releasing hormone (GnRH)/lutein...
Association between GDF-15 and sarcopenia progression in older adults: results from a population-based study [0.03%]
生长分化因子15与老年人少肌症进展的相关性：一项基于人群的研究结果
Yuh-Shiou Gu,Alice Margherita Ornago,Caterina Gregorio et al.
Yuh-Shiou Gu et al.
Background: Growth differentiation factor-15 (GDF-15), a stress-induced cytokine, has been implicated in pathways related to muscle degeneration, although findings regarding its association with sarcopenia remain heteroge...
Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial [0.03%]
阿尔茨海默预防倡议哥伦比亚载脂蛋白显性阿尔茨海默病临床试验中PSEN1E280A突变阳性和阴性认知正常参与者的基线及假手术相关影像学、脑脊液、血浆生物标志物和认知结果
Tobias Bittner,Francisco Lopera,Silvia Rios-Romenets et al.
Tobias Bittner et al.
Background: The Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial evaluated the biological, cognitive, and clinical effects of crenezumab, an anti-oligomeric and monomeric amyl...
Autoantibodies against type I interferons in patients with zoonotic H7N9 influenza: an observational case-control study [0.03%]
人感染H7N9流感患者I型干扰素自身抗体的观察性病例对照研究
Yongkun Chen,Jakob Ankerhold,Tingting Jia et al.
Yongkun Chen et al.
Background: The determinants of the species barrier preventing human infections with avian influenza A viruses (IAV) are incompletely understood. We previously identified loss-of-function variants of the interferon-regula...
Identifying sex-specific sub-phenotypes of Alzheimer's disease progression using longitudinal electronic health records [0.03%]
利用纵向电子健康记录识别阿尔茨海默病进展的性别特异性亚表型
Weimin Meng,Qiang Yang,Jie Xu et al.
Weimin Meng et al.
Background: Alzheimer's Disease (AD) is a complex neurodegenerative disorder, with women comprising nearly two-thirds of individuals with AD. However, sex-specific heterogeneity in AD progression remains insufficiently un...
Chronological versus physiological age for 10-year survival estimation: a real-world healthsystem-wide cohort analysis [0.03%]
基于实际世界的健康体系人群队列分析中的 chronological 和 physiological 年龄在 10 年生存期估计中的作用
Amy C Justice,Janet P Tate,Kathleen A McGinnis et al.
Amy C Justice et al.
Background: Benefits from clinical guidelines often only exceed harms after 10 years (payoff time). Based on population norms, guidelines are often discontinued at 75 years of age, but survival likely differs for those wi...
Ribavirin post-exposure prophylaxis for Andes virus exposure: a viewpoint [0.03%]
安第斯病毒暴露后利巴韦林预防用药的观点性文章
Roger J Brüggemann,Albert Vollaard,Sacha de Stoppelaar et al.
Roger J Brüggemann et al.
Andes virus (ANDV) is unique among hantaviruses because person-to-person transmission is possible. This raises questions on the relevance of post-exposure prophylaxis (PEP), particularly following high-risk household, healthcare-associated,...
Higher amyloid deposition and lower white matter volume in cognitively healthy seniors exceeding French alcohol recommendations [0.03%]
超过法国酒精摄取建议的认知健康老年人中较高的淀粉样蛋白沉积和较低的白质体积
Célia Soussi,Julie Gonneaud,Nicolas Cabé et al.
Célia Soussi et al.
Background: Older adults are particularly vulnerable to alcohol's effects. Our aim was to establish whether differences in neurocognitive health exist between cognitively healthy seniors, depending on whether they follow ...
CardioMorph Atlas: a statistical approach to evaluate association between pulmonary tuberculosis and cardiac morphology from chest X-rays [0.03%]
基于胸部X射线的心脏形态统计分析方法及其与肺结核的相关性研究
Amritpal Singh,Sena Azamat,Gourav Modanwal et al.
Amritpal Singh et al.
Background: Patients with tuberculosis (TB) face an elevated risk of certain cardiovascular diseases. The inflammatory response associated with TB is linked to cardiac complications, though the spatial impact on cardiac s...
Beyond diagnosis: can fluid tau biomarkers stage Alzheimer's disease? Lessons from down syndrome [0.03%]
超越诊断：脑脊液tau生物标志物能 staging 阿尔茨海默病吗？唐氏综合征患者的启示
Lucilla Parnetti,Lorenzo Gaetani
Lucilla Parnetti