Effect of IL-6 receptor inhibition on infarct volume after endovascular treatment for ischaemic stroke: a phase 2, randomised, placebo-controlled trial [0.03%]
白细胞介素6受体抑制对缺血性脑卒中血管内治疗后梗死体积的影响：一项二期、随机、双盲、安慰剂对照试验
Xuehong Chu,Jing Lan,Zhengfei Ma et al.
Xuehong Chu et al.
Background: Tocilizumab, an interleukin-6 receptor inhibitor, is a promising cytoprotective agent selected by the Stroke Preclinical Assessment Network. It showed a protective effect on infarct volume and functional outco...
Digital integrated systems in primary health care: advancing universal health coverage in low- and middle-income countries [0.03%]
基层医疗中的数字一体化系统：推进低收入和中等收入国家的全民健康覆盖
Hadis Ashrafizadeh,Maryam Rassouli
Hadis Ashrafizadeh
Identification and validation of an 11-kinase signature that predicts chemo- and radiosensitivity in gastric cancer [0.03%]
胃癌化疗和放疗敏感性的11种激酶标志物的鉴定与验证
Changyuan Hu,Sung-Young Shin,Yanan Wang et al.
Changyuan Hu et al.
Background: Most gastric cancer (GC) patients receive uniform treatment due to the lack of predictive biomarkers for chemotherapy or radiotherapy. We previously identified epithelial-mesenchymal transition (EMT) and metab...
Region-specific brain structural modulation and amyloid-β pathology associated with dietary biotin: insights into dementia neuropathology [0.03%]
饮食生物素相关的脑结构调节和淀粉样蛋白-β病理改变及其对痴呆神经病理学的启示
Junhan Zhang,Celi Yang,Yuefeng Tan et al.
Junhan Zhang et al.
Background: The association and mechanisms between biotin and dementia remain unclear. Methods: We investigated the association through...
Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance [0.03%]
一种戒酒药物的代谢物可提高放射性同位素摄取量并揭示肿瘤抗消融性的新见解
Katie Brookes,Jessica S Fear,Caitlin E M Thornton et al.
Katie Brookes et al.
Background: Exploitation of the sodium iodide symporter (NIS) has potentially broad clinical application across different tumour ablative settings but often fails in aggressive cancer due to diminished transport activity....
Phenotypic age acceleration and early-onset lung cancer: a case-control and prognostic cohort study involving multiple clinical centres with validation in the UK Biobank [0.03%]
表型年龄加速与早发性肺癌的相关性及预后列队研究——多临床中心研究并利用英国生物样本库进行验证
Ruolin Gao,Yuxuan Liao,Qiwen Zheng et al.
Ruolin Gao et al.
Background: Lung cancer is mainly diagnosed in elderly adults, yet the incidence of early-onset disease in people aged ≤45 years is increasing. Current screening strategies largely target elder populations, leaving young...
Effects of gestational perfluorohexanesulfonic acid exposure at human realistic dose on social communication deficit in mouse offspring [0.03%]
人真实剂量六氟硫酸盐妊娠暴露对子代小鼠社交缺损的影响研究
Shengmei Zhang,Chang Gao,Ruonan Li et al.
Shengmei Zhang et al.
Background: Early-life exposure to exogenous chemicals can disrupt neurodevelopment. Perfluorohexanesulfonic acid (PFHxS), a legacy PFAS widely used and detected globally, remains poorly studied for its neurotoxicity. ...
Reconsidering serological strategies for HPV-driven oropharyngeal cancer screening [0.03%]
重新考虑人乳头瘤病毒驱动的口咽癌筛查的血清学策略
Nitya Krishnasamy,Hema Shree,Sameep Shetty et al.
Nitya Krishnasamy et al.
Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice [0.03%]
运动通过促进肠道适应性和肠肽敏感性来提高小鼠对营养物质的反应能力
Cecilie Bæch-Laursen,Jon Vergara Ucin,Katrine Douglas Galsgaard et al.
Cecilie Bæch-Laursen et al.
Background: Physical activity helps maintain a healthy stable body weight. One mechanism underlying this beneficial effect could be the improved coupling between energy intake and expenditure, since hunger and satiety are...
Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation [0.03%]
环境中的环丙沙星通过TRIM21介导的MFF降解引发胚胎衰老导致小鼠自然流产
Yi Sun 孙义,Yanbing Lin 林晏冰,Shuaishuai Xing 幸帅帅 et al.
Yi Sun 孙义 et al.
Background: Antibiotic abuse has become a top public health problem worldwide. Ciprofloxacin (CIP) has the highest detection rate in human but its association with unexplained miscarriage (UM) is completely unknown. Senes...