Common analysis pitfalls in longitudinal ctDNA studies: lead time, sensitivity and immortal time bias [0.03%]
纵向ctDNA研究的常见分析误区：预警期、灵敏度和永生期偏倚
Dominik Hlauschek,Nadia Dandachi,Michael Gnant et al.
Dominik Hlauschek et al.
Circulating tumour DNA (ctDNA) has emerged as one of the most promising biomarkers in oncology, with potential applications from detection of minimal residual disease (MRD) and diagnosis to prognosis, treatment guidance, and response monito...
COVID-19 vaccination timing, relative to acute COVID-19, and subsequent risk of long COVID [0.03%]
与急性COVID-19相对的COVID-19疫苗接种时间及其对长期COVID风险的影响
Zachary Butzin-Dozier,Yunwen Ji,Lin-Chiun Wang et al.
Zachary Butzin-Dozier et al.
Background: Vaccination is a vital tool in preventing acute COVID-19 and may confer additional protection against Long COVID, although it is unclear whether this protection wanes over time. ...
An experimentally validated structure-based computational framework for humanisation of anti-orthopoxvirus antibodies [0.03%]
一种实验验证的结构基础计算框架用于人源化抗正痘病毒抗体
Xuehua Yang,Xuemeng Dong,Jiahan Lu et al.
Xuehua Yang et al.
Background: The re-emergence of orthopoxviruses, most notably mpox virus (MPXV), poses a growing global public health threat. Well-characterised murine anti-orthopoxvirus antibodies are clinically limited by anti-mouse an...
Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease [0.03%]
HTLV-1c感染和肺部疾病的免疫表型和前病毒景观
Ashley Hirons,Natasha Jansz,Georges Khoury et al.
Ashley Hirons et al.
Background: Human T-lymphotropic virus 1 (HTLV-1) integrates into host DNA, resulting in life-long infection that underlies malignancy, inflammatory disease, and early all-cause mortality. HTLV-1 subtype-C endures as an e...
Investigating the role of baseline gut Akkermansia muciniphila and its co-metabolite palmitoleic acid in BCG vaccine efficacy: a preclinical study [0.03%]
基线肠道阿克曼氏菌和其共代谢产物棕榈油酸对BCG疫苗有效性的作用：一项临床前研究
Dongni Chen,Lingming Chen,Chun Chen et al.
Dongni Chen et al.
Background: Bacillus Calmette-Guérin (BCG) is the only vaccine for tuberculosis (TB) and remains the most effective means of prevention; however, its effectiveness in humans is highly variable with unknown mechanism. ...
Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort [0.03%]
NESDA队列横断面及6年纵向观察血浆代谢组的影响因素
Dennis Klose,Yuri Milaneschi,Laura K M Han et al.
Dennis Klose et al.
Background: The plasma metabolome represents a valuable molecular readout of a person's physiological state, yet its relation to health, stress and lifestyle remains underexplored collectively. ...
Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses [0.03%]
生物钟失衡指数的遗传结构：全基因组关联、性状组广泛关联和梅嫩德尔随机化分析
Magdalena Żebrowska,Matthias Wielscher,Jing Zhang et al.
Magdalena Żebrowska et al.
Background: Circadian disruption affects multiple aspects of human health, but the genetic architecture of individual susceptibility remains unclear. We examined the genetics of the Circadian Imbalance Index (CII), an add...
Single-cell sequencing reveals NK cell dysregulation during chronic HIV infection and identifies transitional NK cell cytotoxicity related to HIV reservoir decay [0.03%]
单细胞测序揭示慢性HIV感染期间NK细胞的失调，并确定过渡性NK细胞细胞毒性与HIV储存库衰减相关
Wen-Jing Cao,Bao-Peng Yang,Si-Yuan Chen et al.
Wen-Jing Cao et al.
Background: Natural killer (NK) cells, as an integral component of the innate immune system, assume a pivotal role in combating viral infections. Our understanding of how human immunodeficiency virus (HIV) infection affec...
Adjuvant aspirin for colorectal cancer with PIK3CA-mutated and COX-2 overexpressed tumours: the ASCOLT translational research study and meta-analysis [0.03%]
针对PIK3CA突变和COX-2高表达结直肠癌辅助阿司匹林的序贯转化研究及meta分析
Eva Segelov,Shan Li,Isabel Li et al.
Eva Segelov et al.
Background: ASCOLT compared adjuvant aspirin versus (vs) placebo in 1587 patients with colorectal cancer (CRC) and reported no significant improvement in disease-free survival (DFS). Subsequently, two randomised controlle...
Neuron-derived neurotrophic factor-positive interneurons: a cellular target for anti-seizure therapies [0.03%]
神经源性神经营养因子阳性中间神经元：抗癫痫治疗的细胞靶点
Amy Richardson,Marion S Mercier,Yoshiteru Shimoda et al.
Amy Richardson et al.
Background: Failure of epilepsy pharmacotherapy is common, justifying efforts to identify optimal cell targets for advanced therapies. Genetic manipulations of the inhibitory system in principle offer a finely tuned inter...