A next-generation probiotic strain for gut health: Bacteroides cellulosilyticus LYH2 variant with anti-inflammatory and metabolic advantages [0.03%]
一种下一代益生菌菌株：具有抗炎和代谢优势的LYH2变异体细胞解糖巴氏杆菌 strains for gut health
Cong Lan,Xiaofeng Deng,Shen Jin et al.
Cong Lan et al.
Background: The rising global incidence of inflammatory bowel disease (IBD) underscores the pressing demand for effective therapeutic approaches. Among promising next-generation probiotics (NGPs), certain Bacteroides spec...
Usefulness of plasma bile acid profile as a prognostic biomarker for drug-induced liver injury [0.03%]
血浆胆酸谱作为药物性肝损伤预后标志物的有效性研究
Maria J Monte,Thi Dong-Binh Tran,Jane I Grove et al.
Maria J Monte et al.
Background: The liver maintains bile acid (BA) homoeostasis; circulating BA levels are used as a biomarker in certain cholestatic conditions. BAs can initiate processes in the pathogenesis of drug-induced liver injury (DI...
Observational Study
EBioMedicine. 2026 Apr:126:106229. DOI:10.1016/j.ebiom.2026.106229 2026
Development and preclinical evaluation of KDTV001, an adenovirus 5-vectored trivalent HPV therapeutic vaccine targeting HPV16/18/52 [0.03%]
KDTV001的开发及临床前评估：一种针对HPV16/18/52的五型腺病毒载体三价人乳头瘤病毒治疗性疫苗
Yilin Dai,Fanwei Huang,Xiaojiao Li et al.
Yilin Dai et al.
Background: Persistent high-risk HPV infections (e.g., HPV16/18/52) are directly linked to cervical cancer development, thus necessitating the development of effective multi-target therapeutic vaccines. ...
Oral microbiota and periodontal health: the oral-brain axis in cognitive ageing [0.03%]
口腔微生物群和牙周健康：认知衰老的口腔-脑轴
Pirkko Pussinen,Muhammed Manzoor
Pirkko Pussinen
Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort [0.03%]
口腔微生物群紊乱联系社区队列中牙周健康与认知衰老
Fei Li,Xiao Liang,Jincheng Li et al.
Fei Li et al.
Background: Emerging evidence implicates the oral-brain axis in neurodegeneration, yet large community-based studies remain limited. This study aimed to examine associations between periodontal health, oral microbiome, an...
Tirzepatide attenuates mesolimbic cocaine-evoked dopamine levels and reduces cocaine taking, motivation and seeking behaviours in male rodents [0.03%]
Tirzepatide可减轻雄性啮齿动物中导水管周围灰质的可卡因诱发的多巴胺水平，并减少可卡因摄取、动机和寻觅行为
Christian E Edvardsson,Xinming Zhang,Thaynnam A Emous et al.
Christian E Edvardsson et al.
Background: Cocaine use disorder (CUD) remains among the most treatment-resistant addictions, characterised by high relapse rates even following extended abstinence periods. Dopamine signalling in mesocorticolimbic circui...
A single-cell and spatial transcriptomic atlas of human tuberculous constrictive pericardium [0.03%]
人结核性缩窄性心包炎的单细胞和空间转录组 atlas
Feng Xiong,Yangran Qi,Shuzhen Wang et al.
Feng Xiong et al.
Background: Tuberculous pericarditis (TP) can progress to tuberculous constrictive pericarditis (TB-CP), a life-threatening fibrotic syndrome. However, the cellular architecture and intercellular circuits that link granul...
Nasal RNA-scaffold-protein vaccine protects mice from human H5N1 clade 2.3.4.4b virus lethal infection and safeguards against vaccine-unmatched viruses [0.03%]
鼻用RNA支架蛋白疫苗可使小鼠免受人类H5N1 2.3.4.4b谱系病毒的致命感染，并对与疫苗不匹配的毒株产生保护作用
Joy-Yan Lam,Chun-Kit Yuen,Shuk-Kwan Cheung et al.
Joy-Yan Lam et al.
Background: Recent cases of H5N1 avian influenza spilling over into human populations have raised concerns once again about the unpredictable emergence of zoonotic viral diseases. This phenomenon highlights the persistent...
Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study [0.03%]
帕金森病患者血液微生物特征的大规模分析及其与疾病进展的关系：横断面研究
Xingxing Jian,Pei Yu,Yi Zhang et al.
Xingxing Jian et al.
Background: Emerging evidence supports the presence of microbial signatures in the blood, yet their clinical relevance remains poorly understood. In this study, we profiled blood microbial signatures in patients with Park...
PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways [0.03%]
过氧化物酶体增殖激活受体γ通过调控脂代谢通路抑制巨噬细胞衰老和哮喘发病
Wenjing Gu,Rongjun Wan,Zhifeng Chen et al.
Wenjing Gu et al.
Background: Cellular senescence has emerged as a key contributor to the pathogenesis of chronic lung diseases. Peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear transcription factor, regulates senescen...