SLC7A9 suppression increases chemosensitivity by inducing ferroptosis via the inhibition of cystine transport in gastric cancer [0.03%]
SLC7A9抑制通过胱氨酸转运抑制诱导铁死亡增加胃癌的化疗敏感性
Haoran Feng,Junxian Yu,Zhuoqing Xu et al.
Haoran Feng et al.
Background: SLC7A9 is responsible for the exchange of dibasic amino acids and cystine (influx) for neutral amino acids (efflux). Cystine/cysteine transport is related to ferroptosis. ...
Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology [0.03%]
磁共振脑老化异质性与认知、遗传和阿尔茨海默病病理的关系
Mathilde Antoniades,Dhivya Srinivasan,Junhao Wen et al.
Mathilde Antoniades et al.
Background: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals...
Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors [0.03%]
CCR5Δ32对丹麦献血者感染风险、携带金黄色葡萄球菌状况及血浆细胞趋化因子浓度的影响
Khoa Manh Dinh,Kathrine Agergård Kaspersen,Susan Mikkelsen et al.
Khoa Manh Dinh et al.
Background: The CC chemokine receptor 5 (CCR5) is a suggested receptor for Staphylococcus aureus leukotoxin ED. Homozygosity for the Δ32 deletion (CCR5Δ32) protects against human immunodeficiency virus infection and pos...
Detection and staging of Alzheimer's disease by plasma pTau217 on a high throughput immunoassay platform [0.03%]
基于高通量免疫分析平台的血浆pTau217检测及其在阿尔茨海默病期别中的应用
Azadeh Feizpour,James David Doecke,Vincent Doré et al.
Azadeh Feizpour et al.
Background: Plasma phospho-tau 217 (pTau217) assays can accurately detect Alzheimer's disease (AD) pathology, but clinical application is limited by the need for specialised equipment. This study tests the performance of ...
Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype [0.03%]
CCR5等位基因野生型个体通过黏膜感染高致病性CXCR4嗜性的HIV-1病毒
Manukumar Honnayakanahalli Marichannegowda,Saini Setua,Meera Bose et al.
Manukumar Honnayakanahalli Marichannegowda et al.
Background: Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest ...
Plasma proteomic signatures of liver steatosis and fibrosis in people living with HIV: a cross-sectional study [0.03%]
HIV感染者的肝脏脂肪变性和纤维化血浆蛋白质组标志物：一项横断面研究
Louise E van Eekeren,Quirijn de Mast,Elise M G Meeder et al.
Louise E van Eekeren et al.
Background: Insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease (MASLD) in people living with HIV (PLHIV) remain limited. Plasma proteomics holds promise for biomarker discovery a...
Multicenter Study
EBioMedicine. 2024 Nov:109:105407. DOI:10.1016/j.ebiom.2024.105407 2024
Single-chain A35R-M1R-B6R trivalent mRNA vaccines protect mice against both mpox virus and vaccinia virus [0.03%]
单链A35R-M1R-B6R三价mRNA疫苗可保护小鼠免受_mpox_病毒和天花病毒的侵害
Tianxiang Kong,Pei Du,Renyi Ma et al.
Tianxiang Kong et al.
Background: Mpox has spread to many countries around the world. While the existing live attenuated mpox vaccines are effective, advances in 21st century technologies now enable the development of vaccines with more specif...
Intermittent preventive treatment for malaria in pregnancy and infant growth: a mediation analysis of a randomised trial [0.03%]
间歇性预防性治疗与婴儿生长发育之间的关系：一项随机试验的中介分析
Yanwei Tong,Kalani Ratnasiri,Suhi Hanif et al.
Yanwei Tong et al.
Background: Intermittent preventive treatment for malaria in pregnancy (IPTp) can improve birth outcomes, but whether it confers benefits to postnatal growth is unclear. We investigated the effect of IPTp on infant growth...
Randomized Controlled Trial
EBioMedicine. 2024 Nov:109:105397. DOI:10.1016/j.ebiom.2024.105397 2024
The impact of temperature on non-typhoidal Salmonella and Campylobacter infections: an updated systematic review and meta-analysis of epidemiological evidence [0.03%]
温度对非伤寒沙门氏菌和弯曲杆菌感染的影响：流行病学证据的系统综述和荟萃分析更新
Yohannes Tefera Damtew,Michael Tong,Blesson Mathew Varghese et al.
Yohannes Tefera Damtew et al.
Background: As temperatures rise, the transmission and incidence of enteric infections such as those caused by Salmonella and Campylobacter increase. This study aimed to review and synthesise the available evidence on the...
Meta-Analysis
EBioMedicine. 2024 Nov:109:105393. DOI:10.1016/j.ebiom.2024.105393 2024
Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progression [0.03%]
整合单细胞转录组分析鉴定前列腺癌进展中涉及的新型系分化相关癌细胞类型
Faming Zhao,Tingting Zhang,Jinlan Wei et al.
Faming Zhao et al.
Background: Cancer cell plasticity is the ability of neoplastic cells to alter their identity and acquire new biological properties under microenvironmental pressures. In prostate cancer (PCa), lineage plasticity often re...