Human effector CD8+ T cells with an activated and exhausted-like phenotype control tumour growth in vivo in a humanized tumour model [0.03%]
人效应CD8+t细胞具有激活和耗尽表型的小鼠模型体内研究
Juliane Mietz,Meike Kaulfuss,Lukas Egli et al.
Juliane Mietz et al.
Background: Humanized tumour models could be particularly valuable for cancer immunotherapy research, as they may better reflect human-specific aspects of the interfaces between tumour and immune system of human cancer. H...
Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak [0.03%]
2018至2020年埃博拉病毒病流行期间的糖代谢异常：回顾性分析
Kasereka Masumbuko Claude,Daniel Mukadi-Bamuleka,Kitenge-Omasumbu Richard et al.
Kasereka Masumbuko Claude et al.
Background: Ebola virus disease (EVD) is associated with multisystem organ failure and high mortality. Severe hypoglycaemia is common, life-threatening, and correctable in critically ill patients, but glucose monitoring m...
Corrigendum to "Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway" [EBioMedicine 38 (2018) 25-36] [0.03%]
关于“山柰素通过HIF-1α信号通路改善缺氧的肿瘤微环境并逆转铂类药物耐药性”的勘误[EBioMedicine 38(2018)25-36]
Yuan Qin,Hui-Juan Liu,Meng Li et al.
Yuan Qin et al.
Published Erratum
EBioMedicine. 2024 Jul 6:106:105237. DOI:10.1016/j.ebiom.2024.105237 2024
Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort [0.03%]
多基因遗传及其与吸烟史在预测肺癌诊断中的相互作用：来自法裔加拿大人群的病例对照队列研究
Véronique Boumtje,Hasanga D Manikpurage,Zhonglin Li et al.
Véronique Boumtje et al.
Background: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS). Methods: ...
Potential clinical applications of advanced genomic analysis in cerebral palsy [0.03%]
基因组分析在脑性瘫痪临床应用的潜在价值
Sara A Lewis,Andrew Ruttenberg,Tuğçe Iyiyol et al.
Sara A Lewis et al.
Cerebral palsy (CP) has historically been attributed to acquired insults, but emerging research suggests that genetic variations are also important causes of CP. While microarray and whole-exome sequencing based studies have been the primar...
Machine learning-based cluster analysis identifies four unique phenotypes of patients with degenerative cervical myelopathy with distinct clinical profiles and long-term functional and neurological outcomes [0.03%]
基于机器学习的聚类分析确定了具有独特临床特征和长期功能及神经结果的四个不同的脊髓型颈椎病表型
Karlo M Pedro,Mohammed Ali Alvi,Nader Hejrati et al.
Karlo M Pedro et al.
Background: Degenerative cervical myelopathy (DCM), the predominant cause of spinal cord dysfunction among adults, exhibits diverse interrelated symptoms and significant heterogeneity in clinical presentation. This study ...
Identification of disease phenotypes in acetylcholine receptor-antibody myasthenia gravis using proteomics-based consensus clustering [0.03%]
基于蛋白质组学共识聚类识别乙酰胆碱受体抗体型重症肌无力的疾病表型
Christopher Nelke,Christina B Schroeter,Sumanta Barman et al.
Christopher Nelke et al.
Background: The clinical heterogeneity of myasthenia gravis (MG), an autoimmune disease defined by antibodies (Ab) directed against the postsynaptic membrane, constitutes a challenge for patient stratification and treatme...
The role and implications of RNAscope and mRNA in the diagnosis of tuberculosis [0.03%]
RNAscope和mRNA在结核病诊断中的作用及意义分析
Ritah F Nakiboneka,Wilber Sabiiti
Ritah F Nakiboneka
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy [0.03%]
前列腺癌治疗的p300肽类蛋白酶靶向嵌合剂（PROTAC）药物发现
Dize Zhang,Bohan Ma,Donghua Liu et al.
Dize Zhang et al.
Background: The E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways in various cancers, including prostate cancer. This...