Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease [0.03%]
利用遗传风险和抗性预测阿尔茨海默病患者脑内淀粉样蛋白-β沉积量及起病年龄
Eleanor K O&#x;Brien,Timothy Cox,Shane Fernandez et al.
Eleanor K O&#x;Brien et al.
Background: Accumulation of brain amyloid beta (Aβ), a key pathological hallmark of Alzheimer's disease (AD), begins decades before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at wh...
Seasonal vaccine-induced immunity shows preserved cross-reactivity to H3N2 subclade K in adults [0.03%]
季节性疫苗诱导的免疫反应保持了对成人H3N2亚群K的交叉反应性
Adria Wilson,Brian Lerman,Reima Ramsamooj et al.
Adria Wilson et al.
Background: Influenza A subclade K viruses caused high infection rates in the 2025/2026 Northern Hemisphere season, raising concerns about antigenic drift and reduced vaccine effectiveness. ...
Lisa Budzinski,Anne Elisabeth Beenken,Toni Sempert et al.
Lisa Budzinski et al.
Background: While the intestinal microbiome has been implicated in Immunoglobulin-4 related disease (IgG4-RD), it remains poorly characterised. Therefore, we performed a comprehensive microbiome characterisation to identi...
Assessment of human immunity to A/H3N2 influenza subclade K during 2025 emergence [0.03%]
人对A/H3N2流感亚谱系K的免疫力评估
Ruth Harvey,Ceilidh Welsh,Alexander Mp Byrne et al.
Ruth Harvey et al.
Background: Seasonal influenza causes significant morbidity and mortality annually. In 2025, the genetically divergent A/H3N2 K subclade (J.2.4.1) emerged with substantial haemagglutinin mutations. However, despite sugges...
Implementing portable, real-time 16S rRNA sequencing in the healthcare sector enhances antimicrobial stewardship [0.03%]
便携式实时16S rDNA测序在医疗保健领域的应用促进抗菌药物的合理使用
Edward Cunningham-Oakes,David Carlisle,June Booth et al.
Edward Cunningham-Oakes et al.
Background: Antimicrobial resistance (AMR) poses a significant global health challenge, resulting in over 1.27 million deaths in 2019 and is projected to cause up to 10 million deaths annually in the future. To address th...
Advances in patient-derived brain organoid models and emerging ethical questions [0.03%]
脑器官芯片模型研究进展与新兴伦理问题思考
eBioMedicine
eBioMedicine
The complement C3-microglial axis in depression of Parkinson's disease: from mechanism to therapeutic intervention [0.03%]
帕金森病抑郁的补体C3-小胶质细胞轴：从机制到治疗干预
Qiao Yin,Mengyang Ding,Yurui Tang et al.
Qiao Yin et al.
Background: Depression is a common and early non-motor symptom of Parkinson's disease (PD) with significant sexual dimorphism, yet its underlying molecular mechanisms remain poorly understood. This study aimed to elucidat...
An immunogenomic classification of solid tumours reveals subtype-specific therapeutic vulnerabilities for immunotherapy [0.03%]
免疫组学分类揭示了实体肿瘤的免疫治疗特异性亚型及治疗弱点
Yiming Zhao,Pei Wang,Zhiren Han et al.
Yiming Zhao et al.
Background: The efficacy of immune checkpoint blockade (ICB) is heterogeneous across patients. Tumour immune phenotype classification (immune-inflamed, -excluded, and -desert) represents a foundational but inadequate fram...
Corrigendum to "PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways" [EBioMedicine 126 (2026) 106226] [0.03%]
关于“PPAR-γ通过控制脂质代谢途径抑制巨噬细胞衰老和过敏性气道炎症”的勘误说明
Wenjing Gu,Rongjun Wan,Zhifeng Chen et al.
Wenjing Gu et al.
Published Erratum
EBioMedicine. 2026 Jun 8:129:106328. DOI:10.1016/j.ebiom.2026.106328 2026
Refined single-cell profiling captures a CCR5high CD4+ cytotoxic T-cell precursor in multiple sclerosis [0.03%]
精细的单细胞分析捕捉到多发性硬化症中的CCR5高CD4+细胞毒性T细胞前体
Fabiënne van Puijfelik,Jasper Rip,Yifan van Hasselt et al.
Fabiënne van Puijfelik et al.
Background: Decades of immunological and genetic studies highlight CD4+ T cells as initiators of central nervous system (CNS) pathology in individuals who develop multiple sclerosis (MS). A low-frequency CD4+ T-cell popul...