Evolutionarily Conserved Epigenetic Regulation of Transcriptional Cell States During Vertebrate Pancreatic Tumorigenesis [0.03%]
脊椎动物胰腺肿瘤发生过程中转录细胞状态的表观遗传调控的保守性演化
Somer M Matar,Sandra Blázquez-Araguás,Andrea Diéguez-Docampo et al.
Somer M Matar et al.
Background & aims: Although the majority of human pancreatic cancers are classified as pancreatic ductal adenocarcinomas, tumors are comprised of diverse dedifferentiated tumor cell states that dynamically interact with a...
Suppressing α-1,6-Fucosyltransferase With a Novel Small Molecule Inhibitor Ameliorates Inflammation in Murine T-Cell-Mediated Colitis Models [0.03%]
一种新型小分子抑制剂诱导岩藻糖转移酶沉默通过改善T细胞介导的结肠炎小鼠模型中的炎症起作用
Akiko Asakura,Shinichiro Shinzaki,Yoshiyuki Manabe et al.
Akiko Asakura et al.
Background & aims: Inflammatory bowel disease involves intractable intestinal inflammation often refractory to current pharmacotherapies. We investigated the therapeutic potential of a novel, orally available inhibitor ta...
Induced pluripotent stem cell-derived hepatocytes from patients with MASLD exhibit early mitochondrial dysfunction [0.03%]
MASLD患者诱导多能干细胞衍生的肝细胞出现早期线粒体功能障碍
Dounia Le Guillou,Kevin Siao,Chris L Her et al.
Dounia Le Guillou et al.
Correction [0.03%]
改正
Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration [0.03%]
构成型雄烯二酮受体调节胆汁酸稳态和肝再生过程中的代谢作用
Weinan Zhou,Ullas Valiya Chembazhi,Jiansheng Huang et al.
Weinan Zhou et al.
Background & aims: Constitutive androstane receptor transcriptionally regulates xenobiotic detoxification, metabolism, and hepatocyte proliferation. Although constitutive androstane receptor activation promotes regenerati...
TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche [0.03%]
肿瘤坏死因子受体1调节结肠间充质细胞多样性及上皮干细胞生态位
Safina Gadeock,Nandini Girish,Cambrian Y Liu et al.
Safina Gadeock et al.
Background & aims: Tumor necrosis factor receptor 1 (TNFR1) regulates intestinal epithelial survival and repair, yet its role in the colonic mesenchyme remains unclear. We investigated how mesenchymal TNFR1 signaling cont...
Dysbiosis-associated LPA primes ICI-induced intestinal barrier dysfunction via the LPAR2-MLCK axis [0.03%]
与LPA相关的失调通过LPAR2-MLCK轴诱导ICI的肠道屏障功能障碍
Lei Xiong,Jianshang Huang,Qiuyuan Liu et al.
Lei Xiong et al.
Background: Immune checkpoint inhibitor (ICI) therapy is frequently limited by severe gastrointestinal toxicity. While the immune mechanisms driving late-stage, overt mucosal inflammation are increasingly recognized, the ...
The SenKiller Mouse: Enabling Cell Type-Specific Ablation of Senescent Cells [0.03%]
SenKiller小鼠：实现特定类型衰老细胞的靶向清除
Xuerui Wu,Eric L Waite,Mark Tigue et al.
Xuerui Wu et al.
Stromal Hedgehog signaling drives segment-specific malignant transformation of gastrointestinal stem cells by producing BMP antagonists [0.03%]
基质Hh信号通过产生BMP拮抗物驱动胃肠上皮干细胞系谱特异的恶性转化
Ping Li,Manju Che,Qi Deng et al.
Ping Li et al.
Background & aims: Hedgehog (HH) signaling plays a complex role in epithelial-stromal interactions, but its effects on gastrointestinal stem cells mediated by heterogeneous stromal cell populations remain incompletely def...
Correction [0.03%]
改正错误