TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche [0.03%]
肿瘤坏死因子受体1调节结肠间充质细胞多样性及上皮干细胞生态位
Safina Gadeock,Nandini Girish,Cambrian Y Liu et al.
Safina Gadeock et al.
Background & aims: Tumor necrosis factor receptor 1 (TNFR1) regulates intestinal epithelial survival and repair, yet its role in the colonic mesenchyme remains unclear. We investigated how mesenchymal TNFR1 signaling cont...
Dysbiosis-associated LPA primes ICI-induced intestinal barrier dysfunction via the LPAR2-MLCK axis [0.03%]
与LPA相关的失调通过LPAR2-MLCK轴诱导ICI的肠道屏障功能障碍
Lei Xiong,Jianshang Huang,Qiuyuan Liu et al.
Lei Xiong et al.
Background: Immune checkpoint inhibitor (ICI) therapy is frequently limited by severe gastrointestinal toxicity. While the immune mechanisms driving late-stage, overt mucosal inflammation are increasingly recognized, the ...
The SenKiller Mouse: Enabling Cell Type-Specific Ablation of Senescent Cells [0.03%]
SenKiller小鼠：实现特定类型衰老细胞的靶向清除
Xuerui Wu,Eric L Waite,Mark Tigue et al.
Xuerui Wu et al.
Stromal Hedgehog signaling drives segment-specific malignant transformation of gastrointestinal stem cells by producing BMP antagonists [0.03%]
基质Hh信号通过产生BMP拮抗物驱动胃肠上皮干细胞系谱特异的恶性转化
Ping Li,Manju Che,Qi Deng et al.
Ping Li et al.
Background & aims: Hedgehog (HH) signaling plays a complex role in epithelial-stromal interactions, but its effects on gastrointestinal stem cells mediated by heterogeneous stromal cell populations remain incompletely def...
Correction [0.03%]
改正错误
Virome-associated hepatitis B protein X drives epithelial-mesenchymal plasticity and enhances colorectal carcinogenesis [0.03%]
与病毒组相关的乙肝蛋白X驱动上皮间质可塑性并增强结直肠癌发生率
Amanda Facoetti,Stefania Cagliani,Luca Massimino et al.
Amanda Facoetti et al.
Single-cell transcriptome profiles of Foxl1-lineage cells along the intestinal crypt-villus axis [0.03%]
Foxl1谱系细胞在肠隐窝-绒毛轴的单细胞转录组图谱
Amal Gharbi,Noa Corem,Sharona Elgavish et al.
Amal Gharbi et al.
Background & aims: Intestinal epithelial cells rely on a complex array of stromal signals to determine their fate and function along the crypt-villus axis, but the precise cellular sources and combinations of signals at e...
TSLP-driven B cell hyper-activation impairs intestinal epithelial homeostasis predisposing to enterocolitis in Hirschsprung disease [0.03%]
Hirschsprung病中TSLP驱动的B细胞活化异常损害肠道上皮稳态易患肠炎
Shiwei He,Ziyi Zheng,Lingdu Meng et al.
Shiwei He et al.
Background & aims: Hirschsprung-associated enterocolitis (HAEC), a lethal complication of Hirschsprung disease (HSCR)-a prevalent congenital disorder with high morbidity-has a poorly understood pathogenesis. We investigat...
Josias J Mürle,Magdalena Filipowicz Sinnreich
Josias J Mürle
Intervening in PIDD1 to Decrease Treg Cell Recruitment Boosts the Effectiveness of Radiofrequency Ablation Combined with anti-PD-1 Therapy in HCC [0.03%]
干预PIDD1以减少Treg细胞招募可增强射频消融联合抗PD-1治疗肝癌的效果
Xu Lu,Zhiyong Xiong,Yongsheng Tang et al.
Xu Lu et al.
Background and aims: The efficacy of radiofrequency ablation (RFA) is constrained by incomplete tumor ablation, particularly in cases of excessive tumor volume, leading to elevated recurrence rates. Elucidating the geneti...