Beatriz Thomasi,Brian D Gulbransen
Beatriz Thomasi
Guiding Principles: Current practices and considerations for benchmarking human gastrointestinal organoids [0.03%]
人类肠道类器官体外培养指导原则：现状及基准参考因素分析
Monica E Brown,Antoine R Gleizes,Qianhui Yu et al.
Monica E Brown et al.
Since the first reports of organoids cultured from primary human small intestine and colonic epithelium in 2011, these systems have held considerable potential to accelerate our understanding of gastrointestinal (GI) biology and disease. Im...
Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases [0.03%]
炎症性肠病中IFN-γ/TNF轴协同作用导致活化肠道神经胶质细胞的选择性丧失
Marvin Bubeck,Klara A Penkert,Heidi Limberger et al.
Marvin Bubeck et al.
Background and aims: Enteric glial cells (EGCs) regulate gastrointestinal homeostasis and inflammation. While activated EGCs have been shown to support epithelial and immune balance in preclinical models, their functional...
Inhibition of ADAMTS13 Activity by Peptidylarginine Deiminase IV Exacerbates Pancreatic Necrosis in Acute Pancreatitis [0.03%]
肽精氨脱亚胺酶IV通过抑制ADAMTS13活性加剧急性胰腺炎的胰腺坏死
Wenjian Mao,Yiting Guan,Zongwen Zhang et al.
Wenjian Mao et al.
Background & aims: Dysregulation of the Von Willebrand factor (VWF) and its protease-ADAMTS13 has been implicated in the pathogenesis of pancreatic necrosis during acute pancreatitis (AP), but the underlying mechanisms re...
Context-dependent epithelial and immune programs shape intestinal resilience or vulnerability following prior colitis [0.03%]
先前结肠炎塑造肠道对后续感染耐受或易损性的分子机制
Priyanka Biswas,Vishwas Mishra,Julia Sanchez-Garrido et al.
Priyanka Biswas et al.
Background & aims: Prior intestinal inflammation can leave durable immune and epithelial alterations, yet how these changes influence responses to subsequent injury remains unclear. Infectious and sterile colitis share co...
Hepatic CBP/p300 maintain bile acid homeostasis through histone acetylation-mediated KLF10-BSEP axis [0.03%]
肝脏CBP/p300通过组蛋白乙酰化介导的KLF10-BSEP轴维持胆汁酸稳态
Mingzhu Li,Yiru Wang,Libin Zhou et al.
Mingzhu Li et al.
Background & aims: Disruption of bile acid metabolism contributes to various liver diseases. Although CBP/p300 are known regulators of hepatic metabolism, their role in bile acid homeostasis remains elusive. ...
Epigenetic Rearrangements Driven by EZH2 Are Linked to Impaired Tissue Regeneration in Neonatal Necrotizing Enterocolitis [0.03%]
EZH2驱动的表观遗传重排与新生儿坏死性肠炎后的组织再生受损有关
Jean-Pierre Etchegaray
Jean-Pierre Etchegaray
Loss of the mechanistic target of rapamycin complexes 1 (mTORC1) causes a lethal alpha-1 antitrypsin deficiency associated liver disease [0.03%]
雷帕霉素靶蛋白复合物1(mTORC1)的丧失导致一种致命的α1抗胰蛋白酶缺乏症相关肝病
Lisa Bewersdorf,Sophie Haber,Ines Volkert et al.
Lisa Bewersdorf et al.
Background & aims: SERPINA1 mutations cause retention of the otherwise secreted alpha-1 antitrypsin (AAT) and lead to the proteotoxic AAT deficiency (AATD)-related liver disease (AATD-LD). As mechanistic target of rapamyc...
SIGIRR-TWIST1 axis regulates barrier function in neonatal intestine [0.03%]
SIGIRR-TWIST1轴调节新生儿肠道屏障功能
Aparna Venkatraman,Wei Yu,Heather L Menden et al.
Aparna Venkatraman et al.
Background: The genetic basis of impaired intestinal barrier function in preterm infants is poorly understood. Variants in single immunoglobulin interleukin-1-related receptor (SIGIRR), a negative regulator of Toll-Like R...