In vivo maturation of human embryonic stem cell-derived teratoma over time [0.03%]
人胚胎干细胞畸胎瘤的体内成熟化过程中的时间变化特征分析
Hidenori Akutsu,Michiyo Nasu,Shojiroh Morinaga et al.
Hidenori Akutsu et al.
Transformation of human embryonic stem cells (hESC) is of interest to scientists who use them as a raw material for cell-processed therapeutic products. However, the WHO and ICH guidelines provide only study design advice and general princi...
Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act [0.03%]
日本《医师法》和《医疗法》下细胞加工设施中自体细胞制造时的污染经验
Manabu Mizutani,Hazuki Samejima,Hiroshi Terunuma et al.
Manabu Mizutani et al.
Cell therapy and regenerative medicine technologies require strict cell manufacturing procedures to be defined and addressed. Maintenance of the aseptic environment is critical to preclude extrinsic contamination risks, similar to conventio...
Dynamic cultivation with radial flow bioreactor enhances proliferation or differentiation of rat bone marrow cells by fibroblast growth factor or osteogenic differentiation factor [0.03%]
动态灌注型平板流式生物反应器通过bfgf和odf促进大鼠骨髓细胞的增殖及分化
Yuuhei Kanda,Itsurou Nishimura,Toru Sato et al.
Yuuhei Kanda et al.
Dynamic cultivation using a radial flow bioreactor (RFB) has gained increasing interest as a method of achieving bone regeneration. In order to enhance bone generation in large bone defects, it is necessary to use an RFB to expand the prima...
Antagomir-92a impregnated gelatin hydrogel microsphere sheet enhances cardiac regeneration after myocardial infarction in rats [0.03%]
载有反义寡核苷酸92a的明胶水凝胶微球片促进心肌梗死后的心脏再生
Masanori Fujita,Hajime Otani,Masayoshi Iwasaki et al.
Masanori Fujita et al.
Introduction: We investigated whether attachment of gelatin hydrogel microsphere (GHM) sheet impregnated with antagomir-92a on the infarcted heart promotes angiogenesis and cardiomyogenesis, and improves cardiac function ...
Computed tomographic evaluation of novel custom-made artificial bones, "CT-bone", applied for maxillofacial reconstruction [0.03%]
新型颌面部重建CT骨计算机断层扫描评估研究
Yuki Kanno,Takashi Nakatsuka,Hideto Saijo et al.
Yuki Kanno et al.
Introduction: We fabricated custom-made artificial bones using three-dimensionally layered manufacturing (3D printing) process, and have applied them to patients with facial deformities. We termed this novel artificial bo...
Response to Nature's editorial regarding the Japanese legal system for regenerative medicines [0.03%]
对《自然》杂志关于日本再生医疗法律体系编辑评论的回应
Daisaku Sato,Yuji Arakawa,Soichiro Isobe
Daisaku Sato
Nature's editorial, dated 10 December 2015, made several criticisms of the new Japanese conditional and time-limited marketing authorization system for regenerative medical products. We believe these comments were based on a misunderstandin...
Cardiac fibroblast-derived VCAM-1 enhances cardiomyocyte proliferation for fabrication of bioengineered cardiac tissue [0.03%]
心脏纤维母细胞衍生的VCAM-1促进心肌细胞增殖以制造生物工程心脏组织
Takahiro Iwamiya,Katsuhisa Matsuura,Shinako Masuda et al.
Takahiro Iwamiya et al.
Background: Fibroblasts are indispensable for the fabrication of cell-sheet-based bioengineered cardiac tissues; however, whether cardiac fibroblasts can improve tissue properties for transplantation or in vitro models co...
Hunghao Chu,Daniel S Kohane,Robert Langer
Hunghao Chu
RNA therapeutics mainly control gene expression at the transcript level. In contrast to conventional gene therapy which solely increases production of a protein, delivered RNAs can enhance, reduce or abolish synthesis of a particular protei...
Expedited approval system for regenerative medicine products - Is it unusual? [0.03%]
日本再生医療产品的优先审批制度-特别还是例外？
Kazuo Yano,Natsumi Watanabe,Masayuki Yamato
Kazuo Yano
Japan's challenges of translational regenerative medicine: Act on the safety of regenerative medicine [0.03%]
日本再生医疗转化研究的挑战：再生医疗安全性法案的影响
Morikuni Tobita,Kenji Konomi,Yasuhiro Torashima et al.
Morikuni Tobita et al.
The first issue of Nature Medicine published 20 years ago featured an article that reported Japan's critical situation regarding clinical trials, calling for major reform. Twenty years later, Japan has enacted three laws to promote the use ...