Full-thickness skin reconstruction with basic fibroblast growth factor-impregnated collagen-gelatin sponge [0.03%]
基本纤维生长因子修饰胶原-明胶支架修复全层皮肤缺损
Hajime Matsumine,Hiroshi Fujimaki,Mika Takagi et al.
Hajime Matsumine et al.
Introduction: This study examined the usefulness of basic fibroblast growth factor impregnated collagen-gelatin sponge (bFGF-CGS) in reconstructive surgery for various acute skin defects including deep dermal burns, facia...
Recognition of, interest in, and understanding of induced pluripotent stem cells and regenerative medicine in Japanese students [0.03%]
日本学生对诱导多能干细胞和再生医学的认识、兴趣及理解程度
Kenji Ishihara,Asuka Ichinomiya,Mami Inami et al.
Kenji Ishihara et al.
We studied the recognition of, interest in, and understanding of induced pluripotent stem (iPS) cells and regenerative medicine in a total of 2659 junior high school, senior high school, and university students. The number of valid response...
Bayesian statistics and clinical trial designs for human cells and tissue products for regulatory approval [0.03%]
基于贝叶斯统计的药械组合产品的临床试验设计及监管考量
Yoji Jokura,Kazuo Yano,Natsumi Watanabe et al.
Yoji Jokura et al.
Introduction: In order to obtain premarket approval for medical products derived from human cells or tissues in the United States (US), the European Union (EU), and Japan, data from clinical trials are typically required ...
Optimization of human mesenchymal stem cell isolation from synovial membrane: Implications for subsequent tissue engineering effectiveness [0.03%]
人滑膜间充质干细胞分离的优化：对后续组织工程有效性的意义
Norihiko Sugita,Yu Moriguchi,Morito Sakaue et al.
Norihiko Sugita et al.
Synovium-derived mesenchymal stem cells (SDMSCs) are one of the most suitable sources for cartilage repair because of their chondrogenic and proliferative capacity. However, the isolation methods for SDMSCs have not been extensively charact...
Clinical experience of full custom-made artificial bones for the maxillofacial region [0.03%]
个性化定制颌面部人工骨临床应用体验
Hideto Saijo,Yuko Fujihara,Yuki Kanno et al.
Hideto Saijo et al.
Introduction: Autologous, allogeneic, and artificial bones are clinically applied as graft materials for bone reconstruction, with each having their own advantages and disadvantages. Although artificial bones with various...
Preparation of a nitric oxide imaging agent from gelatin derivative micelles [0.03%]
明胶衍生物胶束硝基荧光染料的制备及细胞内一氧化氮位点成像研究
Mikio Tatsutomi,Jun-Ichiro Jo,Yasuhiko Tabata
Mikio Tatsutomi
Introduction: Nitric oxide (NO) is an intracellular and intercellular messenger that plays an important role in cellular events in physiological and pathophysiological processes. NO is one of the inflammation markers and ...
Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells [0.03%]
等离子活化培养基可选择性清除未分化的人诱导多能干细胞
Ryo Matsumoto,Kazunori Shimizu,Takunori Nagashima et al.
Ryo Matsumoto et al.
Human pluripotent stem cells, including human induced pluripotent stem cells (hiPSCs), are promising materials for regenerative medicine and cell transplantation therapy. However, tumorigenic potential of residual undifferentiated stem cell...
Application of cell growth analysis to the quality assessment of human cell-processed therapeutic products as a testing method for immortalized cellular impurities [0.03%]
细胞生长分析在人细胞加工治疗产品品质评估中作为永生化细胞杂质检测方法的应用研究
Nozomi Hasebe-Takada,Ken Kono,Satoshi Yasuda et al.
Nozomi Hasebe-Takada et al.
In human cell-processed therapeutic products (hCTPs) for clinical application, tumorigenic cellular impurities in the manufacturing process are a major concern. Because cellular immortalization is one of the prerequisite steps in tumorigene...
Generating tissue-engineered intestinal epithelium from cultured Lgr5 stem cells in vivo [0.03%]
在体外培养的Lgr5干细胞生成组织工程化肠上皮
Zhassulan Baimakhanov,Yasuhiro Torashima,Akihiko Soyama et al.
Zhassulan Baimakhanov et al.
Introduction: Generating tissue-engineered small intestine (TESI) from mature intestinal cells has been established in a mouse model. The purpose of this study was to generate TESI from Lgr5 stem cells in vivo. ...
Corneal regenerative medicine [0.03%]
角膜再生医学
Yoshinori Oie,Kohji Nishida
Yoshinori Oie
Recently, regenerative medicine has become a highlighted field because it has great potential to induce a paradigm shift of supportive conventional therapy into definitive treatment. The cornea is the avascular, transparent, dome-shaped out...