Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial) [0.03%]
普拉克索治疗肌萎缩侧索硬化症的临床试验方案：一项随机、双盲、安慰剂对照及开放标识延续的单中心一期/二期临床试验（ROPALS试验）
Satoru Morimoto,Shinichi Takahashi,Komei Fukushima et al.
Satoru Morimoto et al.
Introduction: Amyotrophic lateral sclerosis (ALS) is an intractable and incurable neurological disease. It is a progressive disease characterized by muscle atrophy and weakness caused by selective vulnerability of upper a...
Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial) [0.03%]
盐酸罗匹尼罗治疗肌萎缩侧索硬化症的疗效研究——随机双盲安慰剂对照单中心一期/二期临床试验方案（ROPALS试验）
Satoru Morimoto,Shinichi Takahashi,Komei Fukushima et al.
Satoru Morimoto et al.
Introduction: Amyotrophic lateral sclerosis (ALS) is an intractable and incurable neurological disease. It is a progressive disease characterized by muscle atrophy and weakness caused by selective vulnerability of upper a...
Ruxolitinib treatment for acute gastrointestinal graft-versus-host disease caused by donor-derived CD19-Chimeric antigen receptor T-Cell infusion in a patient with B-ALL relapsed after Allo-HSCT [0.03%]
一例B细胞急性淋巴细胞白血病患者 allo-HSCT 后复发接受供者来源的CD19-CART 细胞输注后出现急性的肠道移植物抗宿主病并用鲁索利替尼治疗
Yingying Yang,Yongxian Hu,He Huang
Yingying Yang
Preparation of polymer microspheres capable for pioglitazone release to modify macrophages function [0.03%]
制备载吡格列酮聚合物微球以调控巨噬细胞功能
Naoki Momotori,Jun-Ichiro Jo,Yasuhiko Tabata
Naoki Momotori
Introduction: Macrophages play an important role in regulating inflammation and tissue regeneration. It is known that anti-inflammatory macrophages play an important role for tissue regeneration. The objective of this stu...
Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy [0.03%]
基于生物材料的核酸递送系统在再生医疗研究和治疗中的应用
Jun-Ichiro Jo,Jian-Qing Gao,Yasuhiko Tabata
Jun-Ichiro Jo
Regenerative medicine is a new and promising medical method aiming at treating patients with defective or dysfunctional tissues by maintaining or enhancing the biological activity of cells. The development of biomaterial-based technologies,...
The secretome of adipose-derived mesenchymal stem cells attenuates epithelial-mesenchymal transition in human corneal epithelium [0.03%]
人脂肪来源间充质干细胞分泌组抑制人角膜上皮的上皮间质转化
Shun Shibata,Ryuhei Hayashi,Toru Okubo et al.
Shun Shibata et al.
Introduction: Epithelial-mesenchymal transition (EMT) induces the loss of cell-cell interactions in polarized epithelial cells and converts these cells to invasive mesenchymal-like cells. It is also involved in tissue fib...
Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial [0.03%]
自体骨髓间充质干细胞关节镜下微骨折移植与单独微骨折治疗膝关节软骨损伤的多中心前瞻性随机对照临床试验研究
Yusuke Hashimoto,Yohei Nishida,Shinji Takahashi et al.
Yusuke Hashimoto et al.
Introduction: To investigate the efficacy of the transplantation of autologous bone marrow-derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) compared with microfracture alone. ...
Increased error-free DNA repair gene expression through reprogramming in human iPS cells [0.03%]
人类iPSC通过重编程提高无误DNA修复基因的表达
Yasuhide Yoshimura
Yasuhide Yoshimura
Introduction: Many studies have reported that human-induced pluripotent stem (hiPS)/embryonic stem (hES) cells have an exceptional ability to repair damaged DNA. Moreover, unlike differentiated cells, hES cells have featu...
Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming [0.03%]
多能干细胞分化的心肌细胞和直接心脏重编程在心脏再生中的应用
Taketaro Sadahiro
Taketaro Sadahiro
Cardiovascular disease is the leading cause of death globally. Cardiomyocytes (CMs) have poor regenerative capacity, and pharmacological therapies have limited efficacy in severe heart failure. Currently, there are several promising strateg...
Analysis of human nasal mucosal cell sheets fabricated using transported tissue and blood specimens [0.03%]
基于运送组织和血液标本制备的人鼻粘膜上皮细胞片的分析研究
Yoshiyuki Kasai,Tsunetaro Morino,Shun Kikuchi et al.
Yoshiyuki Kasai et al.
Previously, we succeeded in transplanting autologous nasal mucosal cell sheets in the middle ears of 5 patients, who underwent cholesteatoma resection, which prevents recurrence of cholesteatoma in clinical settings. Current good manufactur...