Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue [0.03%]
体外创建三维心脏组织的大规模血管生成
Akitoshi Inui,Hidekazu Sekine,Kazunori Sano et al.
Akitoshi Inui et al.
Introduction: The definitive treatment for severe heart failure is transplantation. However, only a small number of heart transplants are performed each year due to donor shortages. Therefore, novel treatment approaches b...
Proliferation medium in three-dimensional culture of auricular chondrocytes promotes effective cartilage regeneration in vivo [0.03%]
耳软骨细胞三维培养增殖性培养基可促进体内有效软骨再生
Ryuji Okubo,Yukiyo Asawa,Makoto Watanabe et al.
Ryuji Okubo et al.
Introduction: Cartilage regeneration have been attracted attentions because of the poor ability of cartilage tissues to regenerate. Three-dimensional (3D) culture of chondrocytes is considered to be advantageous for carti...
Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets [0.03%]
包裹诱导多能干细胞来源的心肌细胞片构建搏动性管状心肌组织
Shinpei Tsuruyama,Katsuhisa Matsuura,Katsuhisa Sakaguchi et al.
Shinpei Tsuruyama et al.
The purpose of this study was to fabricate pulsatile tubular cardiac tissue using cell sheet based-tissue engineering. First, we fabricated human induced pluripotent stem cell (hiPSc)-derived cardiomyocyte sheets and normal human dermal fib...
An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts [0.03%]
骨形成性化合物helioxanthin抑制破骨细胞形成
Hitoshi Amano,Futoshi Iwaki,Meiko Oki et al.
Hitoshi Amano et al.
Objective: The helioxanthin derivative 4-(4-methoxyphenyl)thieno[2,3-b:5,4-c']dipyridine-2-carboxamide (TH) is a low-molecular-weight compound that was identified through screening for osteogenic compounds that enhance th...
Long non-coding RNA ANRIL promotes proliferation, clonogenicity, invasion and migration of laryngeal squamous cell carcinoma by regulating miR-181a/Snai2 axis [0.03%]
长链非编码RNA ANRIL通过调节miR-181a/Snai2轴促进喉鳞状细胞癌的增殖、集落形成、侵袭和转移
Yan-Ru Hao,De-Jun Zhang,Ze-Ming Fu et al.
Yan-Ru Hao et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is the common cancer with poor prognosis. Long non-coding RNA (lncRNA) ANRIL has been proven to play an important role in many cancers. However up to now, the role of A...
Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions [0.03%]
低氧培养的间充质干细胞比常氧培养的间充质干细胞更能有效治疗肝硬化小鼠
Yuichi Kojima,Atsunori Tsuchiya,Masahiro Ogawa et al.
Yuichi Kojima et al.
Background: Mesenchymal stem cells (MSCs) can be easily expanded. They can be acquired from medical waste such as adipose and umbilical cord tissues, are influenced by culturing conditions, and exert anti-inflammatory, an...
Intact extracellular matrix component promotes maintenance of liver-specific functions and larger aggregates formation of primary rat hepatocytes [0.03%]
完整细胞外基质成分促进原代大鼠肝细胞更大聚合体的形成及肝特异性功能的维持
Ronald P Bual,Hiroyuki Ijima
Ronald P Bual
The extracellular matrix (ECM) in a liver-specific extracellular matrix (L-ECM) scaffold facilitates hepatocyte viability and maintains hepatocyte functions in vitro. However, whether an intact composition of ECM is required for an efficien...
Regulatory approval for autologous human cells and tissue products in the United States, the European Union, and Japan [0.03%]
美国、欧盟和日本监管批准的自体人细胞和组织产品注册上市要求比较研究
Kazuo Yano,Natsumi Watanabe,Kenichiro Tsuyuki et al.
Kazuo Yano et al.
Human cells and tissue products belong to a relatively new class of medical products. Therefore, limited information is available on the classification and premarket evaluation of human cells and tissue products in the United States (US), t...
KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression [0.03%]
KLF4通过抑制内源TGF-β2防止人角膜上皮细胞向间充质转化
Satoko Fujimoto,Ryuhei Hayashi,Susumu Hara et al.
Satoko Fujimoto et al.
Introduction: Krüppel-like factor 4 (KLF4) is considered one of the Yamanaka factors, and recently, we and others have shown that KLF4 is one of the transcription factors essential for reprogramming non-human corneal epi...
Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration [0.03%]
聚羟基乙酸-胶原神经导管中的去分化脂肪细胞促进大鼠面神经再生
Hiroshi Fujimaki,Hajime Matsumine,Hironobu Osaki et al.
Hiroshi Fujimaki et al.
Introduction: Polyglycolic acid (PGA) nerve conduits, an artificial biodegradable nerve regeneration-inducing tube currently used in clinical practice, are effective in regenerating peripheral nerves. Dedifferentiated fat...