Mesenchymal stem cell-based tissue regeneration therapies for periodontitis [0.03%]
基于间充质干细胞的牙周炎组织再生疗法
Takehito Ouchi,Taneaki Nakagawa
Takehito Ouchi
Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. T...
Preparation of antibody-immobilized gelatin nanospheres incorporating a molecular beacon to visualize the biological function of macrophages [0.03%]
用于可视化巨噬细胞生物功能的抗体包被明胶纳米球的制备及分子信标载运能力研究
Yu Yoshimoto,Jun-Ichiro Jo,Yasuhiko Tabata
Yu Yoshimoto
Introduction: Inflammatory response plays an important role in the disease progress or therapeutic effect. In this context, it is highly required to develop a technology to visualize the inflammatory response. In this stu...
A novel rat model of inflammatory bowel disease developed using a device created with a 3D printer [0.03%]
一种新型炎症性肠病大鼠模型：采用3D打印装置诱导造模
Tomoko Kuriyama,Masayuki Yamato,Jun Homma et al.
Tomoko Kuriyama et al.
Objective: Inflammatory bowel disease (IBD) is an intractable condition. Existing models of experimental IBD are limited by their inability to create consistent ulcers between animals. The aim of this study was to develop...
Ryuichi Okamoto,Hiromichi Shimizu,Kohei Suzuki et al.
Ryuichi Okamoto et al.
Inflammatory bowel disease (IBD) consists of two major idiopathic gastrointestinal diseases: ulcerative colitis and Crohn's disease. Although a significant advance has been achieved in the treatment of IBD, there remains a particular popula...
Variation in the manufacturing reproducibility of autologous cell-based products depending on raw material shipment conditions [0.03%]
原料运输条件对自体细胞系产品制造再现性影响的差异分析
Manabu Mizutani,Hiroshi Terunuma,Hazuki Samejima et al.
Manabu Mizutani et al.
To prepare an autologous cell-based product in a cell processing facility, the raw material, which is collected from a patient, must first be shipped from a medical institution to the facility. The quality of this raw material varies depend...
A distribution-based approach for determining lot sizes in the filling of human-induced pluripotent stem cells [0.03%]
一种基于分布的确定填充人类诱导多能干细胞批量大小的方法
Hirokazu Suigyama,Masaki Shiokaramatsu,Masahiro Kino-Oka
Hirokazu Suigyama
Introduction: Toward the commercial production of human-induced pluripotent stem (hiPS) cells, the process design and operation have to be standardized. Considering the change in cell quality during filling of the hiPS ce...
Kinetic modeling of human induced pluripotent stem cell expansion in suspension culture [0.03%]
悬浊液培养的人诱导多能干细胞扩增的kinetic模型研究
Vytautas Galvanauskas,Rimvydas Simutis,Suman Chandra Nath et al.
Vytautas Galvanauskas et al.
To date, practical application of mathematical models for model-based design of stem cell expansion processes is limited. Nevertheless, the first attempts show vast potential of this approach for the improvement of expansion process perform...
Numerical investigation of particle dispersion in the preprocessing stage for a static cell cultivation [0.03%]
静态细胞培养预处理阶段颗粒分散的数值分析
Atsushi Sekimoto,Yoshiki Kanemaru,Yasunori Okano et al.
Atsushi Sekimoto et al.
In order to produce high-quality cells in a static culture, the initial placement of the cells is one of the most important factors. Dense distribution of the cells increases the risk of cell death. Thus, the cells need to be uniformly dist...
A novel tool for suspension culture of human induced pluripotent stem cells: Lysophospholipids as a cell aggregation regulator [0.03%]
一种新的人类诱导多能干细胞悬浮培养工具——溶血磷脂作为细胞聚集调节剂
Masato Ibuki,Ikki Horiguchi,Yasuyuki Sakai
Masato Ibuki
Suspension culture for the increase in human induced pluripotent stem cells (hiPSCs) has been one of the major challenges. Previously, we reported that albumin-associated lipids prevented aggregation of hiPSCs, whereas, lipids responsible f...
Size-dependent hepatic differentiation of human induced pluripotent stem cells spheroid in suspension culture [0.03%]
悬浮培养中人类诱导多能干细胞球大小依赖性肝细胞分化能力的影响
Fuad Gandhi Torizal,Keiichi Kimura,Ikki Horiguchi et al.
Fuad Gandhi Torizal et al.
Suspension culture of three-dimensional (3D) spheroid of human induced pluripotent stem cells (hiPSCs) has been known as a potential method to enhance the scalability of hepatic differentiation of hiPSCs. However, the impact of size-related...