Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles [0.03%]
快速积聚纤维化非酒精性脂肪肝炎模型的建立及其间充质干细胞和小型细胞外囊泡治疗研究
Takayuki Watanabe,Atsunori Tsuchiya,Suguru Takeuchi et al.
Takayuki Watanabe et al.
Introduction: Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory ...
Msx2 plays an important role in BMP6-induced osteogenic differentiation of two mesenchymal cell lines: C3H10T1/2 and C2C12 [0.03%]
MSX2在BMP6诱导的两个间充质细胞系（C3H10T1/2和C2C12）成骨分化中的重要作用研究
Chuan Cai,Jing Wang,Na Huo et al.
Chuan Cai et al.
Bone morphogenetic proteins (BMPs), have been shown to enhance the osteogenic differentiation of mesenchymal cells (MCs) and to promote bone formation. BMP6 is known to play an important role in the process of MCs towards osteogenic differe...
Chitosan-cartilage extracellular matrix hybrid scaffold induces chondrogenic differentiation to adipose-derived stem cells [0.03%]
壳聚糖-软骨基质杂化支架诱导脂肪来源干细胞向软骨细胞分化
I-Chan Lin,Tsung-Jen Wang,Chien-Liang Wu et al.
I-Chan Lin et al.
Introduction: Adipose-derived stem cells (ASCs) are potential cell sources for cartilage tissue engineering. Chitosan has been shown to enhance the stemness and differentiation capability of ASCs, and the native extracell...
Articular chondrocytes from osteoarthritic knee joints of elderly, in vitro expanded in thermo-reversible gelation polymer (TGP), exhibiting higher UEA-1 expression in lectin microarray [0.03%]
老年骨关节炎膝关节软骨细胞体外扩增于温敏性凝胶聚合物（TGP）中，白桦脂醇微阵列表达升高
Shojiro Katoh,Atsuki Fujimaru,Rajappa Senthilkumar et al.
Shojiro Katoh et al.
Autologous chondrocytes in vitro expanded, are used as tools of regenerative therapies for cartilage injuries. However, inability to maintain the hyaline phenotype both in vitro and post in vivo transplantation, remains one of the major hur...
Exosomes from adipose-derived stem cells protect against high glucose-induced erectile dysfunction by delivery of corin in a streptozotocin-induced diabetic rat model [0.03%]
脂肪源性干细胞外泌体通过递送corin保护糖尿病大鼠高糖所致的勃起功能障碍
Jian Wang,Yuanyuan Mi,Sheng Wu et al.
Jian Wang et al.
Introduction: Increasing study have found that stem cell transplantation have a therapeutical effect to diabetes mellitus (DM)-induced erectile dysfunction (ED). So, the aim of this study was to evaluate the beneficial ef...
Evaluation of the proliferative potential of skin keratinocytes and fibroblasts isolated from critical limb ischemia patients [0.03%]
评估来自重症肢体缺血患者皮肤角质形成细胞和成纤维细胞增殖潜能的能力
Fujio Toki,Daisuke Nanba,Emi K Nishimura et al.
Fujio Toki et al.
Impaired wound healing in critical limb ischemia (CLI) results from multiple factors that affect many cell types and their behavior. Epidermal keratinocytes and dermal fibroblasts play crucial roles in wound healing. However, it remains unc...
Development of an efficient vitrification method for chondrocyte sheets for clinical application [0.03%]
一种高效透明质化方法的开发，用于软骨细胞片的临床应用
Asuka Hayashi,Miki Maehara,Ayuko Uchikura et al.
Asuka Hayashi et al.
Introduction: Regenerative therapy using chondrocyte sheets is effective for osteoarthritis. The clinical application of chondrocyte sheet therapy is expected to be further advanced by the use of a feasible cryopreservati...
The importance of scoring recognition fitness in spheroid morphological analysis for robust label-free quality evaluation [0.03%]
球形形态分析中得分识别适应度的重要性以实现稳健的无标记质量评估
Kazuhide Shirai,Hirohito Kato,Yuta Imai et al.
Kazuhide Shirai et al.
Because of the growing demand for human cell spheroids as functional cellular components for both drug development and regenerative therapy, the technology to non-invasively evaluate their quality has emerged. Image-based morphology analysi...
A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-β1 release system [0.03%]
结合TGF-β1释放系统的癌相关成纤维细胞聚集的癌症侵袭模型
Teruki Nii,Kimiko Makino,Yasuhiko Tabata
Teruki Nii
Introduction: The objective of this study is to design a cancer invasion model where the cancer invasion rate can be regulated in vitro. Methods: ...
Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7 cells via inactivating cannabinoid receptor type 2 with AM630 [0.03%]
Nrf2通过用AM630抑制大麻素受体类型2来抑制破骨细胞RANKL诱导的RAW 264.7细胞分化不可缺少
Wan Li,Yongxin Sun
Wan Li
Objective: Nuclear factor-erythroid 2-related factor 2 (Nrf2) is shown to as a negative-regulatory cause in osteoclasts differentiation. Cannabinoid receptor type 2 (CB2) is verified to regulate osteoclast differentiation...