Recombinant canine basic fibroblast growth factor-induced differentiation of canine bone marrow mesenchymal stem cells into voltage- and glutamate-responsive neuron-like cells [0.03%]
重组犬表皮生长因子诱导犬骨髓间充质干细胞向电压和谷氨酸盐响应性神经元样细胞分化的机制研究
Kazuya Edamura,Yusuke Takahashi,Airi Fujii et al.
Kazuya Edamura et al.
Introduction: Basic fibroblast growth factor (bFGF) is a promising cytokine in regenerative therapy for spinal cord injury. In this study, recombinant canine bFGF (rc-bFGF) was synthesized for clinical use in dogs, and th...
The integrity of chemically treated plasmid DNA as a chemical-based choice for prion clearance [0.03%]
化学法处理的质粒DNA的完整性作为朊病毒清除的化学方法选择的真实性评估
Nozomi Takada,Yasuharu Niwa,Tomoaki Teshigawara et al.
Nozomi Takada et al.
In regenerative medical products for clinical applications, a major concern is the risk of ruminant-derived materials developing transmissible spongiform encephalopathy (TSE) in the manufacturing process. Because of the risk of TSE causing ...
PPAR-δ agonist affects adipo-chondrogenic differentiation of human mesenchymal stem cells through the expression of PPAR-γ [0.03%]
过氧化物酶体增殖激活受体-δ激动剂通过调节人骨髓间充质干细胞中过氧化物酶体增殖激活受体-γ的表达影响其向软骨细胞和脂肪细胞的分化
Dong Hyun Kim,Dong Hwan Kim,Bruce E Heck et al.
Dong Hyun Kim et al.
Introduction: Peroxisome proliferator-activated receptor (PPAR) subfamily play an important role in chondrogenesis. Previous study has reported that mixture of GW0742 (PPAR-δ agonist), hyaluronic acid (HA) and mesenchyma...
Collagenase treatment of cartilaginous matrix promotes fusion of adjacent cartilage [0.03%]
基质金属蛋白酶处理的软骨基质促进相邻软骨融合
Ching-Chuan Jiang,Chang-Hsun Hsieh,Chun-Jen Liao et al.
Ching-Chuan Jiang et al.
In articular cartilage-repair, grafts usually fuse unsatisfactorily with surrounding host cartilage. Enzymatic dissociation of cartilaginous matrix to free chondrocytes may benefit fusion. We tested such a hypothesis with human cartilage in...
Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells) [0.03%]
多能非致瘤干细胞的再生潜力：多功能应激耐受细胞（MUSE细胞）
Jiankun Cao,Zhigang Yang,Ran Xiao et al.
Jiankun Cao et al.
Multilineage differentiating stress enduring cells (Muse cells), double positive for SSEA-3 and CD105, can be isolated by fluorescence-activated cell sorting (FACS) or sever cellular conditions from dermal fibroblasts, bone marrow stem cell...
Osteochondral regeneration using scaffold-free constructs of adipose tissue-derived mesenchymal stem cells made by a bio three-dimensional printer with a needle-array in rabbits [0.03%]
基于生物三维打印针阵的脂肪源间充质干细胞构建体用于兔骨软骨再生研究
Daiki Murata,Yoshihiro Kunitomi,Kaori Harada et al.
Daiki Murata et al.
Osteoarthritis is a major joint disease for which medical interventions have been extensively investigated in humans and animals. In this study, we examined the regeneration of articular cartilage and subchondral bone using a scaffold-free ...
TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells promote proliferation, migration and fibrotic activity in rotator cuff tenocytes [0.03%]
富含TGF-β1的骨髓间充质干细胞源小胞体促进肩袖腱细胞增殖、迁移和纤维化活性
Jia Li,Zheng-Peng Liu,Cong Xu et al.
Jia Li et al.
Objective: This study aimed to investigate effects of TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells (BMSC) on cell function of rotator cuff tenocytes and its implication to rotator cuff tear....
Long-term observation of airway reconstruction using decellularized tracheal allografts in micro-miniature pigs at growing stage [0.03%]
生长阶段微小型猪气道重建用脱细胞同种异体移植气管长期观察研究
Michinobu Ohno,Yasushi Fuchimoto,Masataka Higuchi et al.
Michinobu Ohno et al.
Introduction: Decellularized tissue exhibits cell matrix-like properties, along with reduced antigenicity. We explored the potential of decellularized allogeneic trachea to restore the upper respiratory tract, focusing on...
Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood [0.03%]
人脐血中神经嵴样干细胞的分离及特征分析
Zena Al-Bakri,Mika Ishige-Wada,Noboru Fukuda et al.
Zena Al-Bakri et al.
Introduction: Neural crest (NC)-like stem/progenitor cells provide an attractive cell source for regenerative medicine because of their multipotent property and ease of isolation from adult tissue. Although human umbilica...
Full small molecule conversion of human fibroblasts to neuroectodermal cells via a cocktail of Dorsomorphin and Trichostatin A [0.03%]
二药组合完全重编程人纤维细胞成为神经外胚层细胞
Samaneh Sadat Hosseini Farahabadi,Kamran Ghaedi,Alireza Shoaraye-Nejati et al.
Samaneh Sadat Hosseini Farahabadi et al.
A revolutionary new approach to produce efficient cells is to induce transdifferentiation to make it conventional in therapeutic strategies. In this paper, we describe a brief cocktail of small molecules including Dorsomorphin (DSM) and Tri...