Successful treatment of relapsed acute B-cell lymphoblastic leukemia with CD20/CD22 bispecific chimeric antigen receptor T-cell therapy [0.03%]
应用CD20/CD22双特异性嵌合抗原受体T细胞治疗复发性急性B系淋巴细胞白血病取得成功
Zuyu Liang,Jiazhen Cui,Alex Hongsheng Chang et al.
Zuyu Liang et al.
Urinary bladder reconstruction using autologous collagenous connective tissue membrane "Biosheet®" induced by in-body tissue architecture: A pilot study [0.03%]
自体胶原结缔组织膜"Biosheet（注册商标）"诱导的体内组织结构在膀胱重建中的应用：一项初步研究
Yasumasa Iimori,Ryosuke Iwai,Kengo Nagatani et al.
Yasumasa Iimori et al.
Introduction: In-body tissue architecture (iBTA) technology, based on cell-free tissue engineering, can produces collagenous tissues for implantation by subcutaneous embedding a designed mold. The aim of this study was to...
Gaps between Asian regulations for eligibility of human mesenchymal stromal cells as starting materials of cell therapy products and comparability of mesenchymal stromal cell-based products subject to changes in their manufacturing process [0.03%]
关于人间充质基质细胞治疗产品的起始材料资格以及制造过程变化对其产品一致性问题的亚洲法规差距分析
Toshimitsu Tanaka,Shing-Mou Lee,Mayu Mikami et al.
Toshimitsu Tanaka et al.
Working group 2 (WG2) of the Asia Partnership Conference of Regenerative Medicine has discussed eligibility of mesenchymal stromal cells (MSCs) as starting cells for the manufacture of cell therapy products, and comparability before and aft...
Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator [0.03%]
利用3D打印仿真器进行内窥镜细胞片移植的新型装置原型设计
Hiroaki Osada,Wen-Jin Ho,Hideki Yamashita et al.
Hiroaki Osada et al.
Introduction: Considering higher risks of candidates for cardiac regenerative therapy with compromised cardiac function, it is anticipated to develop less invasive surgical procedures. In the present study, we aimed to de...
Development of a bioanalytical method for circulating human T cells in animals using Arthrobacter luteus-based quantitative polymerase chain reaction and its application in preclinical biodistribution studies [0.03%]
利用黄色微球菌建立人源T细胞外周血体液分析方法及其在药代动力学研究中的应用
Hisao Shimizu,Yoji Kuze,Tomoaki Higuchi et al.
Hisao Shimizu et al.
Introduction: In the development of cell therapy products for human use, studies on the biodistribution of transplanted cells in animals are important for assessing the safety and efficacy of these products. Although a fe...
Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue [0.03%]
牙髓干细胞响应支架的纳米拓扑结构以再生牙本质-牙髓复合组织
Rasda Diana,Retno Ardhani,Yulita Kristanti et al.
Rasda Diana et al.
The study of regenerative dentistry receives a fast growing interest. The potential ability of the dentin-pulp complex to regenerate is both promising and perplexing. To answer the challenging nature of the dental environment, scientists ha...
Heparin-conjugated collagen as a potent growth factor-localizing and stabilizing scaffold for regenerative medicine [0.03%]
用作再生医学中高效生长因子定位和稳定的肝素化胶原支架
Yasuhiro Ikegami,Hideyuki Mizumachi,Kozue Yoshida et al.
Yasuhiro Ikegami et al.
Introduction: Growth factors are crucial bioactive molecules in vitro and in vivo. Among them, basic fibroblast growth factor (bFGF) has been used widely for various applications such as cell culture and regenerative medi...
Olga Miroshnychenko,Robert J Chalkley,Ryan D Leib et al.
Olga Miroshnychenko et al.
Background: Autologous blood products, such as platelet-rich plasma (PRP) are commercial products broadly used to accelerate healing of tissues after injuries. However, their content is not standardized and significantly ...
Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars [0.03%]
暴露于口腔菌斑的牙髓用三抗生素糊剂或氢氧化钙盖髓的反应 MOUSE磨牙中的研究
Angela Quispe-Salcedo,Takuichi Sato,Junko Matsuyama et al.
Angela Quispe-Salcedo et al.
Introduction: Responses of oral-microflora-exposed dental pulp to a triple antibiotic paste (TAP), a mixture of ciprofloxacin, metronidazole, and minocycline in ointment with macrogol and propylene glycol, remain to be fu...
Three-dimensional spheroid culture of canine hepatocyte-like cells derived from bone marrow mesenchymal stem cells [0.03%]
由骨髓间充质干细胞衍生的犬肝细胞样细胞的三维球状体培养
Suguru Nitta,Masaharu Hisasue,Yu Horiguchi et al.
Suguru Nitta et al.
Introduction: Primary cultured hepatocytes are an important model for early safety evaluations of newly developed drugs. Many factors, however, hinder the wider applications of this technology, especially the difficulty t...