Innovative synergy of bone xenograft and quercetin in the alveolar bone socket: Histological and immunohistochemical assessment of healing [0.03%]
骨异种移植物与芸香素的创新协同作用：牙槽骨窝愈合的组织学和免疫组化评估
Christian Khoswanto,Ira Kusuma Dewi
Christian Khoswanto
Background: After an extraction, the alveolar bone may undergo shrinkage, making it more challenging to place dental implants and compromising the appearance of prosthetic rehabilitation. Studies show that alveolar bone r...
Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling [0.03%]
circ-CDK8表达异常通过调控let-7b-5p/MAP4K3信号影响牙周病发生发展
Yabo Li,Cailing Yang,Mengdie Jin et al.
Yabo Li et al.
Periodontitis, a chronic inflammatory disorder characterized by progressive alveolar bone loss, relies heavily on the osteogenic differentiation capacity of periodontal ligament stem cells for bone regeneration. While inflammatory condition...
Mesenchymal stromal cell administration promotes macrophage-mediated bile duct regeneration [0.03%]
间充质基质细胞给药通过促进巨噬细胞介导的胆管再生来改善肝纤维化病情发展
Takanori Igarashi,Naruhiro Kimura,Hiroyuki Abe et al.
Takanori Igarashi et al.
Introduction: Mesenchymal stromal cell (MSC) therapy is used in cirrhosis models of chronic hepatocellular damage and represents a novel therapeutic approach for liver regeneration. However, no studies have examined MSC t...
Wharton's jelly mesenchymal stem cell-secretome enhances skin rejuvenation via ApoA4 and SERPINH1 [0.03%]
沃顿胶间充质干细胞分泌组通过载脂蛋白A4和热休克蛋白40促进皮肤年轻化
Na Eun Lee,Jong Ik Hwang,Chi Young Bang et al.
Na Eun Lee et al.
Introduction: Skin aging arises from intrinsic processes and extrinsic insults (e.g., ultraviolet exposure and oxidative stress). Mesenchymal stromal cell (MSC)-derived secretome offers a cell-free approach to skin regene...
RAD51 promotes osteogenic differentiation and inhibits DNA damage in osteoporosis though regulating cGAS-STING signaling pathway [0.03%]
RAD51通过调节cGAS-STING信号通路促进成骨分化和抑制骨质疏松症中的DNA损伤
Minli Qiu,Peili He,Zena Chen et al.
Minli Qiu et al.
Introduction: Osteoporosis (OP) represents a metabolic bone disorder characterized by reduced bone density and increased fracture susceptibility, primarily caused by an imbalance between bone resorption and formation. Ost...
Intra-articular injections of platelet-rich plasma suppress cartilage degeneration in a mouse model of knee osteoarthritis [0.03%]
富血小板血浆膝关节腔内注射通过抑制软骨变性治疗膝骨关节炎（OA）小鼠模型
Yasumasa Momoi,Yoshitomo Saita,Ryosuke Nakajima et al.
Yasumasa Momoi et al.
Introduction: Pain-relieving drugs, such as nonsteroidal anti-inflammatory drugs and hyaluronic acid, are standard treatments for knee osteoarthritis (OA); however, no disease-modifying drugs exist for knee OA. Platelet-r...
Airway basal stem cell derived extracellular vesicles promote lung repair in chronic obstructive pulmonary disease [0.03%]
气道基底干细胞源性外泌体促进慢性阻塞性肺疾病肺脏修复
Mengyu Zou,Ying Hua,Yu Zhao et al.
Mengyu Zou et al.
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by irreversible damage to the airways, alveoli, and pulmonary microvasculature. As the third leading cause of ...
Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability [0.03%]
每月多次注射浓缩生长板因子血小板稀释液（ACP）治疗膝关节骨关节炎：不同KL分级的临床疗效、四次给药后的剂量饱和效应及两年疗效持续性研究
Masahiko Kemmochi
Masahiko Kemmochi
Background: Monthly, ultrasound-guided intra-articular injections of leukocyte-poor platelet-rich plasma (ACP®) are widely used for knee osteoarthritis (KOA), but optimal dosing and cumulative exposure remain unclear. ...
A thermo-responsive sol-to-gel phase transition hydrogel for sustained delivery of mesenchymal stem cell-derived exosomes [0.03%]
一种用于间充质干细胞衍生的外泌体持续递送的温敏溶胶-凝胶水凝胶
Lefeng Liu,Lijuan Yang,Zhiguo Xu et al.
Lefeng Liu et al.
Introduction: Mesenchymal stem cells-derived exosomes (MSC-Exo) have significant therapeutic potential in regenerative medicine but face challenges such as rapid systemic clearance and poor retention at target sites. In t...
Efficacy and safety of autologous adipose-derived stem cells combined with platelet-rich plasma for periodontal regeneration: a multicenter, randomized, open-label, parallel-group comparative trial [0.03%]
自体脂肪源性干细胞联合富血小板血浆治疗牙周病的疗效和安全性：一项多中心、随机、开放标签、平行对照临床试验
Morikuni Tobita,Yosuke Masubuchi,Yorimasa Ogata et al.
Morikuni Tobita et al.
Introduction: Periodontitis is a chronic inflammatory disease caused by dental biofilm that destroys the periodontal tissues supporting the teeth. We aimed to evaluate the efficacy and safety of co-transplantation of auto...