Hiroki Shioda,Tien-Hsiang Tang,Irina Raykhel et al.
Hiroki Shioda et al.
Kidney organoids have the possibility to vastly advance renal medicine, both as an organ model and as a cell source for regenerative medicine. While significant improvements have been made in recreating organ specific lineages, one area tha...
Role of WIF-1 in regulating chondrocyte dedifferentiation and matrix production through WNT pathway [0.03%]
WIF-1通过Wnt信号调节软骨细胞去分化和基质生成的作用研究
Yu-Ying Chu,Yukiyo Asawa,Naoki Tsuji et al.
Yu-Ying Chu et al.
Introduction: Chondrocyte dedifferentiation during monolayer expansion is a major barrier to producing clinically reliable cells for cartilage regeneration. The upstream regulators governing this phenotypic instability ar...
Sustained release of quercetin through homogeneous poly (lactic-co-glycolic acid) microspheres to enhance MSCs biofunctions for regenerative therapy [0.03%]
通过均匀的聚乳酸-こ glycolic acid微球持续释放山柰酚以增强MSCs生物功能用于再生治疗
Xianghui Mei,Dongchao Li,Li Sun et al.
Xianghui Mei et al.
Introduction: Mesenchymal stem cells (MSCs) hold significant potential for tissue repair and cell therapy. A primary obstacle in their application is the loss of stemness and onset of senescence during in vitro expansion,...
Stable and functional regulatory T cell attenuates fibrotic remodeling in heart failure [0.03%]
稳定的具有功能的调节性T细胞减轻心力衰竭中的纤维化重塑
Takura Taguchi,Takuji Kawamura,Norihisa Mikami et al.
Takura Taguchi et al.
Introduction: Heart failure involves myocardial fibrosis and impaired cardiac function. The transverse aortic constriction (TAC) model in mice replicates pressure overload-induced fibrosis. Immune-mediated inflammation, p...
Anti-inflammatory and immunomodulatory effects of human induced pluripotent stem cells-derived mesenchymal stem/stromal cells and their extracellular vesicles [0.03%]
人诱导多能干细胞来源的间充质基质/干细胞及其细胞外囊泡的抗炎和免疫调节作用
Yusaku Komoike,Daisuke Kamiya,Haruka Sasaki-Ban et al.
Yusaku Komoike et al.
Introduction: Mesenchymal stem/stromal cells (MSCs) are multipotent cells that secrete multiple factors for tissue regeneration. These tissue-derived MSCs can self-renew, but their numbers are limited and decrease with ag...
Can cell-based therapies bridge the gap between research and reality in the treatment of myocarditis? A systematic review and meta-analysis [0.03%]
细胞治疗能否弥合研究与实际治疗心肌炎之间的差距？系统评价和meta分析
Ulugbek Yakhshimurodov,Kizuku Yamashita,Sho Komukai et al.
Ulugbek Yakhshimurodov et al.
Introduction: Myocarditis is a non-ischaemic myocardial injury caused by infectious agents, immune-mediated diseases, cardiotoxic drugs, and vaccines. Treatment options are largely supportive, with emphasis on close monit...
Leukocyte-rich versus leukocyte-poor platelet-rich plasma for Osteoarthritis: A systematic review [0.03%]
富含白细胞与脱去白细胞富血小板血浆治疗骨关节炎的系统评价研究
Marta Martín-Vega,Álvaro Gómez-Carrión,Ignacio Zaragoza-García et al.
Marta Martín-Vega et al.
Introduction: Osteoarthritis is an increasingly prevalent condition with limited conservative treatments. Platelet-rich plasma (PRP) therapy has gained attention, but its efficacy may depend on the type used. In particula...
Which trajectory should we choose? - Defining safe entry-target pathways and underlying femoral morphology for bone marrow injection in osteonecrosis of the femoral head [0.03%]
哪种轨迹更适合髓芯减压治疗股骨头缺血性坏死？—基于安全路径的股骨形态学研究
Ken Tashiro,Yasuhiro Homma,Yuto Kawamura et al.
Ken Tashiro et al.
Introductions: Bone marrow aspiration concentrate (BMAC) injection is a promising joint-preserving treatment for osteonecrosis of the femoral head (ONFH). However, the procedure remains unstandardized, and iatrogenic comp...
Genomic analysis of dental pulp mesenchymal stromal cells for therapeutic applications [0.03%]
用于细胞疗法的牙髓间充质干细胞基因分析
Kunio Hirai,Yuko Nitahara-Kasahara,Yuko Okamoto et al.
Kunio Hirai et al.
Introduction: Changes in cell characteristics and the accumulation of gene mutations during expansion culture present significant challenges for the clinical translation of stem cell transplantation technologies. Reduced ...
Regulatory insights on adeno-associated virus-based gene therapies, cell- and tissue-based products, and CAR-T cell therapies: report from the 8th Asia Partnership Conference of Regenerative Medicine, April 24, 2025 [0.03%]
第八届亚洲再生医学合作伙伴大会(APOCR)监管报告：关于腺相关病毒基因疗法、细胞和组织产品以及CAR-T细胞治疗的见解(2025年4月24日)
Shunsuke Tominaga,Yoshie Tsurumaki,Yusuke Kagawa et al.
Shunsuke Tominaga et al.
The 8th Asia Partnership Conference of Regenerative Medicine (APACRM) was held in a hybrid format-both in person and online-on April 24, 2025, to advance regulatory harmonization for regenerative medicine products across Asia. Understanding...