Identification of myocardial contractility-related genes as regenerative targets and diagnostic biomarkers in coronary artery disease [0.03%]
识别与心肌收缩力相关的心肌梗死后再生治疗靶点及冠状动脉疾病诊断标志物基因
Fangzhou Qu,Xifeng An,Yaqi Lei et al.
Fangzhou Qu et al.
Background: Coronary artery disease (CAD) causes irreversible myocardial dysfunction and progressive heart failure due to loss of contractile function and limited endogenous regenerative capacity. Current therapeutic stra...
Establishment of a novel deep learning-based method for gait analysis after peripheral nerve injury in pigs [0.03%]
建立一种新型基于深度学习的猪外周神经损伤后步态分析方法
Junpei Nakayama,Kentaro Okuyama,Ryuken Uda et al.
Junpei Nakayama et al.
Background: Peripheral nerve injury with deficits has poor functional prognosis, making motor function assessment during nerve regeneration crucial. Recently, pigs have been used as research animals for peripheral nerve r...
Hypoxia conditioned adipose-derived stem cell-derived extracellular vesicle therapy improves cardiac function in a rat model of ischemic cardiomyopathy [0.03%]
缺血性心肌病大鼠模型中低氧诱导的脂肪来源干细胞外泌体治疗改善心脏功能
Kunitaka Kumagai,Takuji Kawamura,Kosuke Torigata et al.
Kunitaka Kumagai et al.
Introduction: Extracellular vesicles (EVs) are potential cell-free therapies for cardiac regeneration. Although adipose-derived stem cells (ADSCs) are easily obtained using minimally invasive procedures, therapeutic effec...
Lung cancer cell-derived exosomal EHF drives M2 macrophage polarization via transcriptional activation of RNF41 to promote tumor progression [0.03%]
肺癌细胞源外泌体EHF通过转录激活RNF41驱动M2型巨噬细胞极化以促进肿瘤进展
Zhongjie Chen,Junjie Ying,Gang Huang et al.
Zhongjie Chen et al.
Background: M2 macrophage polarization in the tumor microenvironment drives lung cancer progression. ETS homologous factor (EHF) is overexpressed in lung cancer and linked to malignancy. However, the mechanism by which EH...
WTAP stabilizes MMP12 expression to promote the malignant phenotypes of esophageal cancer cells [0.03%]
WTAP通过稳定MMP12表达促进食管癌细胞恶性表型
Min Zhao,Heng Zhang,Xue Han et al.
Min Zhao et al.
Background: Esophageal cancer (EC) is a highly aggressive malignancy with a poor prognosis, largely due to its invasive nature and metabolic reprogramming. Matrix metalloproteinase 12 (MMP12) has been implicated in variou...
Pathing the way from regulatory approval to market access for gene therapy products (GTPs): An integrative review in the US, EU5, Japan and China [0.03%]
从监管批准到基因治疗产品市场准入的路径：美国、欧盟五国、日本和中国的整合评价研究
Junnan Shi,Hao Hu,Carolina Oi Lam Ung
Junnan Shi
Background: This study aimed to summarize the current practices and mechanisms of market access, pricing and reimbursements for gene therapy products (GTPs) in major jurisdictions, and to identify the key barriers and fac...
3D-printing flexible PLGA scaffold modified with bioorthogonal IGF-1 for skin regeneration [0.03%]
用于皮肤再生的可生物正交IGF-1修饰的PLGA柔性支架的3D打印技术
Yi Zhang,Qi Fang,Xiao Yang
Yi Zhang
Introduction: 3D-printing implants have attracted increasing attention for enhancing the regeneration of various wound types. The rigidity of traditional 3D printing materials limits their applicability in skin wound repa...
Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis [0.03%]
藤黄茋和板蓝根多糖通过抑制TLR4/NF-κB信号通路减轻PTOA软骨损伤及炎症反应
Zhengjiao Duan,Hongpan Gao,Panpan Li et al.
Zhengjiao Duan et al.
Background: Post-traumatic Osteoarthritis (PTOA) is a common secondary joint disease characterized by cartilage degradation, subchondral bone remodeling, and synovial inflammation following joint trauma. Current therapeut...
Advances in In Vitro Vascularization of Engineered Tissues: From Microvessel Formation to Hepatic Tissue Integration [0.03%]
体外工程技术血管化研究进展：从微血管形成到肝组织整合
Yen-Hsiang Huang,Akira Ono,Ryo Sudo
Yen-Hsiang Huang
Advances in tissue engineering have enabled the construction of two-dimensional tissues such as skin and cornea, as well as avascular three-dimensional (3D) tissues such as cartilage. However, building fully functional 3D tissues and organs...
Harnessing Platelet-derived factors to reactivate Nucleus Pulposus cells in Intervertebral Disc Regeneration [0.03%]
利用血小板衍生因子激活椎间盘髓核细胞促进椎间盘再生修复
M Nardini,A Muraglia,A Zanirato et al.
M Nardini et al.
Introduction: Degenerative disc disease (DDD) is a significant healthcare challenge, particularly in the elderly population. Current treatment options range from conservative approaches to invasive surgical interventions....