Exploration of the optimal retention method in vivo for stem cell therapy: Low-intensity ultrasound preconditioning [0.03%]
探究干细胞治疗体内最优留存方法：低强度超声波预处理
Haopeng Xu,Yilin Tang,Wenjing Mao et al.
Haopeng Xu et al.
Bone marrow mesenchymal stem cells (BMSCs) are pluripotent and self-renewing, exerting a crucial role in the domain of regenerative medicine. Nevertheless, BMSCs encounter challenges such as low cell viability and inadequate homing during t...
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition [0.03%]
富集miR-145的骨髓间充质干细胞外泌体通过抑制TGFBR2改善老龄大鼠神经源性勃起功能障碍
Yude Hong,Zejia Feng,Yunlong Ge et al.
Yude Hong et al.
Background: Neurogenic erectile dysfunction (ED) is a prevalent complication following radical prostatectomy in elderly patients, primarily resulting from the apoptosis of corpus cavernosum smooth muscle cells (CCSMCs) an...
In vivo effect of platelet gel on human tendon and ligament healing: A narrative review [0.03%]
血小板凝胶对人类肌腱和韧带愈合的体内影响：叙述性综述
Che-Yu Lin,Yi-Chung Shu,Wei-Ting Wu et al.
Che-Yu Lin et al.
Tendon and ligament injuries remain a significant challenge for clinicians, despite considerable efforts to develop effective treatment methods. This study reviewed in vivo human studies investigating the use of platelet gel, a blood-derive...
Gallic acid protect against spinal cord ischemia-reperfusion injury in rat via activation of Nrf2/HO-1 signaling [0.03%]
没食子酸通过激活Nrf2/HO-1信号通路保护脊髓缺血再灌注损伤
Zhengqiang Liu,Huili Cai,Tianlun Wang et al.
Zhengqiang Liu et al.
Object: This study explores Gallic acid's (GA) neuroprotective effects against spinal cord ischemia-reperfusion injury (SCII) and its underlying mechanisms. ...
Operator stress factors and cell contamination risks in cell processing facilities: An online survey-based analysis [0.03%]
基于在线调查的细胞处理设施人员压力因素及微环境染菌风险分析
Yoshimi Sugahara,Mitsuru Mizuno,Noe Miyashita et al.
Yoshimi Sugahara et al.
The field of regenerative medicine is rapidly evolving, with an increasing number of approved cell preparations. However, cell processing facilities (CPFs) still heavily rely on manual operations by cell processing operators (CPOs). The int...
Regulatory insights on gene therapies, adeno-associated virus-based gene therapies, cell/tissue-based products, and medical care/practice in cell and gene therapies: Report from the 7th Asia partnership conference - April 25, 2024 [0.03%]
第七届亚洲合作伙伴大会基因疗法、基于腺相关病毒的基因疗法、细胞/组织基产品以及细胞和基因疗法医疗护理/实践监管见解报告-2024年4月25日
Yoshie Tsurumaki,Yusuke Kagawa,Shigeaki Hayashi et al.
Yoshie Tsurumaki et al.
The 7th Asia Partnership Conference of Regenerative Medicine (APACRM) was held both in person and online on April 25, 2024, to promote the regulatory harmonization of regenerative medicine products across Asia. Recognizing domestic regulato...
Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling [0.03%]
脊髓损伤恢复和神经环路重塑过程中NMDAR信号转导的机遇与挑战
Han Gong,Xin Xu,Zuliyaer Talifu et al.
Han Gong et al.
N-methyl-d-aspartate receptors (NMDARs) are essential for excitatory synaptic transmission in the central nervous system, contributing to various physiological and pathological functions including learning, memory, neural development, synap...
Bioengineered tracheal graft with enhanced vascularization and mechanical stability for functional airway reconstruction [0.03%]
一种用于功能性气道重建的促血管生成及机械性能增强的生物工程气管移植物
Yu Liang,Shixiong Wei,Anling Zhang
Yu Liang
Tracheal reconstruction remains a formidable clinical challenge due to the complex structural, biomechanical, and physiological requirements of the airway. Traditional approaches, including autologous grafts, allografts, and synthetic prost...
Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential [0.03%]
靶向p53-p21信号通路以增强间充质干细胞的再生潜能
Ahsas Goyal,Muhammad Afzal,Nawaid Hussain Khan et al.
Ahsas Goyal et al.
Mesenchymal stem cells (MSCs) are properties of self-renewal and differentiation potentials and thus are very appealing to regenerative medicine. Nevertheless, their therapeutic potential is frequently constrained by senescence, limited pro...
Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells [0.03%]
月经血来源干细胞修复子宫内膜的新疗法：阿什曼综合征动物模型中的治疗效果及机制研究
Sena Awano-Kim,Satoshi Hosoya,Ryo Yokomizo et al.
Sena Awano-Kim et al.
Endometrium is vital to the establishment of pregnancy through its cyclical regeneration, which, when disrupted, can lead to endometrial thinning and Asherman's syndrome (AS). AS is characterized by infertility, pelvic pain, menstrual irreg...