Basic Points to Consider for Cell Storage under the Act on the Safety of Regenerative Medicine in Japan [0.03%]
日本再生医学安全法细胞存储的基本注意事项
Yuki Uno,Kazuaki Nakamura,Morikuni Tobita et al.
Yuki Uno et al.
Regenerative medicine is an emerging field of medical treatment characterized by numerous uncertainties, necessitating regulatory frameworks that ensure both patient safety and timely clinical application. Among the three legislative measur...
Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid-β pathology [0.03%]
人多能干细胞来源的大脑类器官揭示了催产素介导的淀粉样蛋白病理损伤保护作用
Tomoki Asaba,Sayuri Hamano,Ayaka Nanmo et al.
Tomoki Asaba et al.
Introduction: Neuroinflammation is a key contributor to the pathogenesis of Alzheimer's disease (AD), and impaired clearance of amyloid-β (Aβ) by microglia is closely associated with disease progression. Oxytocin (OXT),...
Mid-term outcomes of a bio-artificial pleura composed of autologous dermal fibroblasts used to close intraoperative pulmonary air leaks caused by intraoperative pleural injury: A case report [0.03%]
自体皮肤成纤维细胞生物人工胸膜的中期疗效用于术中因胸膜损伤导致肺部漏气的封闭（一例报告）
Masato Kanzaki,Ryo Takagi,Shota Mitsuboshi et al.
Masato Kanzaki et al.
Introduction: The visceral pleura is a thin, serous membrane that closely covers the surface of the lung. The pleura is injured or ruptured, causing air to accumulate in the thoracic cavity and the lung to collapse. Incre...
Detailed revisions to the subordinate regulation following the amendment of the Act on the Safety of Regenerative Medicine in Japan [0.03%]
日本《再生医疗安全性保障法》修正后其下位法的修改完善
Satoshi Hosoya,Yuichiro Ukon,Kazuki Morita et al.
Satoshi Hosoya et al.
The amended Act on the Safety of Regenerative Medicine (RM Act) in Japan expands its scope to include in vivo gene therapy and related technologies, classifying them into Class I, the highest-risk category. Furthermore, the amended RM Act i...
Influence of extracorporeal shockwaves on macrophage polarization in a 3D collagen matrix [0.03%]
体外冲击波对三维胶原基质中巨噬细胞极化的影响
Diana Heimes,Moritz Große-Leege,Nadja Engel et al.
Diana Heimes et al.
Introduction: The host's immune response determines the success of guided tissue regeneration. Extracorporeal shockwave therapy (ESWT) has been shown to reduce inflammation and improve wound healing. Nevertheless, its imp...
BNIP3 induced by hypoxia supports the survival of mesenchymal stromal cells (MSCs) after intravenous cell transplantation [0.03%]
缺氧诱导的BNIP3对静脉输注移植后间质干细胞(MSCs)存活的影响支持
Toshiyuki Takehara,Takatoshi Tsujimoto,Fumie Ikebuchi et al.
Toshiyuki Takehara et al.
Introduction: Mesenchymal stromal cells (MSCs) are widely recognized as a valuable cell source for transplantation therapy due to their anti-inflammatory and tissue-regenerative properties in various inflammatory disorder...
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication [0.03%]
纳秒脉冲电场通过恢复线粒体到细胞核的逆向信号传导来复活衰老的内皮细胞
Meifang Yin,Jie Xiao,Guangtao Huang et al.
Meifang Yin et al.
Introduction: Endothelial cell aging is strongly associated with mitochondrial dysfunction, particularly the disruption of mitochondrial-nuclear retrograde communication (MNRC), which is essential for sustaining cellular ...
Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research [0.03%]
体外冲击波治疗烧伤瘢痕修复的机制研究：基于免疫激活的瘢痕重塑研究进展
Yixiang Jin,Zilun Meng,Zhengyuan Qin et al.
Yixiang Jin et al.
Extracorporeal Shock Wave Therapy (ESWT) plays a key role in burn scar treatment through its immunoregulatory effects, influencing inflammation, fibrosis remodeling, and angiogenesis. These mechanisms collectively mediate scar repair, highl...
Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models [0.03%]
犬间充质干细胞源外泌体的长效释放可修复啮鼠脊髓损伤模型中的运动功能
Hidetaka Nishida,Haruhi Matsuura,Karin Yoshizaki et al.
Hidetaka Nishida et al.
Introduction: Extracellular vesicles (EVs) are expected to be a novel promotes in regenerative therapy. EVs derived from canine mesenchymal stromal/stem cells (MSCs) have been shown to play an important role in tissue rep...
Silvia de la Calle,Mercedes Zurita
Silvia de la Calle
Hemorrhagic stroke, which is also called an intracerebral hemorrhage, is a cerebrovascular disease that represents a serious public health problem worldwide. Among all types of stroke, intracerebral hemorrhage causes the highest percentage ...