Neuronal migration into injured tissue: mechanisms and therapeutic strategies for brain regeneration [0.03%]
神经元向受损组织迁移：脑再生的机制和治疗策略
Yuzuki Hara,Kazuya Kuboyama,Kazunobu Sawamoto
Yuzuki Hara
Neuronal migration is a crucial process not only for brain development but also for neural regeneration after injury. It has been reported that some new neurons generated in the ventricular-subventricular zone (V-SVZ) migrate toward tissue ...
Bypassing pluripotency: The promise of direct differentiation from reaggregated micro-fat into multilineage organoids [0.03%]
绕过多能性：微脂肪再聚集直接分化为多谱系类器官的前景
Zhi Qi Lum,Koichiro Iohara,Eiji Kobayashi
Zhi Qi Lum
Organoid technologies have emerged as powerful tools in regenerative medicine; however, current organoid technologies are predominantly based on pluripotent stem cell-derived systems, which poses challenges related to complexity, maturation...
In vitro generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents [0.03%]
体外生成具有生理离子电流的人胚胎干细胞源性心脏器官模型
Jiyoung Lee,Hiroshi Matsukawa,Kohei Sawada et al.
Jiyoung Lee et al.
Introduction: Recently, methods for in vitro organogenesis have been widely developed due to their strong potential for medical applications. Cardiac organoids with functional ion channel activity are necessary for non-cl...
Environmental monitoring practices relevant to regenerative medicine manufacturing: Insights from a cross-sector survey of regulated facilities in Japan [0.03%]
日本规范设施跨界调查中与再生医学制造相关的环境监测实践的启示
Mitsuru Mizuno,Tomoko Oono,Kana Takahashi et al.
Mitsuru Mizuno et al.
Introduction: Environmental monitoring (EM) is essential for contamination control in regenerative medicine manufacturing, where aseptic handling and operator-dependent processes require adaptable yet robust strategies. A...
Therapeutic frontiers in ALS: iPSC-based drug discovery, cell therapy, and gene therapy-Advances through 2026 [0.03%]
ALS治疗新进展：基于iPSC的药物发现、细胞疗法和基因疗法——截至2026年的进展
Satoru Morimoto,Chris Kato,Shinichi Takahashi et al.
Satoru Morimoto et al.
Three converging therapeutic paradigms-iPSC-based drug discovery, cell transplantation, and gene therapy-have substantially expanded the therapeutic pipeline for amyotrophic lateral sclerosis (ALS) between 2020 and 2026. The FDA's accelerat...
Menstrual blood-derived stromal cells exhibit superior protection against lung injury in myocardial Infarction-Induced heart failure in rats compared to bone marrow-derived stromal cells [0.03%]
与骨髓来源基质细胞相比，月经血来源的基质细胞在心肌梗死诱导的心力衰竭中表现出更佳的抗肺损伤保护作用
Mahmood Manshori,Zahra Saffarian,Nahid Aboutaleb et al.
Mahmood Manshori et al.
Introduction: Lung injury is a frequent complication following heart failure (HF) due to systemic inflammation, hypoxia, and reduced cardiac function. This study compared the therapeutic effects of menstrual blood-derived...
Biosafety-cabinet wipe-cleaning assessment system: Integration of visual, thermal, and pressure sensing [0.03%]
基于视觉、温度和压力感应的生物安全柜擦拭消毒评估系统
Mitsuru Mizuno,Yasue Kishino,Yoshinari Shirai et al.
Mitsuru Mizuno et al.
Introduction: Reliable surface disinfection of biosafety cabinets is essential to prevent contamination in pharmaceutical, clinical, and laboratory environments. However, manual cleaning using ethanol (ETH) and wiping is ...
Long-term expandable auricular chondrocytes reveal a conserved nine-gene decline module underlying senescence-independent dedifferentiation [0.03%]
长期可扩增的耳软骨细胞揭示了一个保守的九基因下降模块，该模块独立于衰老的去分化现象
Dilinapa Alemujiang,Naoki Tsuji,Tomoaki Sakamoto et al.
Dilinapa Alemujiang et al.
Introduction: Primary chondrocytes often lose matrix-forming capacity during in vitro expansion, limiting scalable cartilage engineering. Here, we examined aging-independent regulation of chondrogenic function during long...
Dental pulp cell-derived conditioned culture media promotes periodontal repair through immunomodulation and bone regeneration [0.03%]
牙髓细胞条件培养基通过免疫调节和骨再生促进牙周修复
Sanshiro Kanazawa,Sayaka Ono,Hiroki Shinchi et al.
Sanshiro Kanazawa et al.
Introduction: Periodontitis is a chronic inflammatory disease characterized by progressive destruction of periodontal tissues, including alveolar bone. Although various regenerative approaches have been explored, effectiv...
Extracellular vesicles subpopulation derived of clonal mesenchymal stem cells protected retinal ganglion cells in mouse model with optic nerve crush [0.03%]
克隆间质干细胞来源的细胞外小泡亚群在视神经损伤鼠模型中保护了视网膜神经节细胞
Leila Satarian,Nasim Eslami,Rezvaneh Saeedi-Fard et al.
Leila Satarian et al.
Introduction: Recent studies have shown that Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have significant potential to protect retinal ganglion cells (RGCs) function. Here, EVs were obtained from variou...