Assessment of the official national insurance coverage of regenerative medical products for ophthalmic diseases in Japan following regulatory approval [0.03%]
日本再生医药品眼科领域上市后官方国民医保覆盖率评估研究
Kenichi Kimura,Kojiro Imai,Morio Ueno et al.
Kenichi Kimura et al.
Introduction: Recently, significant progress has been made in the field of regenerative medicine in Japan for the treatment of ophthalmic diseases, with a notable emphasis placed on clinical research and practical applica...
The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling [0.03%]
脐带血外泌体MFG-E8通过GSK3β/β-连环蛋白信号通路恢复自噬流并抑制铁死亡从而缓解新生大鼠缺氧缺血性脑病损伤
Menghua Zhao,Yizhong Wu,Li Huang et al.
Menghua Zhao et al.
Background: Recent studies have revealed importance of human umbilical cord blood (HUCB)-derived exosomes (HUCB-Exo) in central nervous system diseases, but the role of HUCB-Exo in hypoxic-ischemic encephalopathy (HIE) re...
Tracking adipose-derived mesenchymal stromal cells in the eye: Integrating IVIS imaging and Alu PCR for enhanced detection of human cells [0.03%]
脂肪来源的间充质干细胞在眼内的追踪：整合IVIS成像和Alu PCR以增强人类细胞的检测能力
Robert M Rusch,Emi Inagaki,Kentaro Ago et al.
Robert M Rusch et al.
Introduction: Cell transplantation finds broad applications in medical science, with applications ranging from stem cell therapies to cancer research. Despite its widespread use, inherent risks such as tumor formation and...
Current challenges and future directions of ATMPs in regenerative medicine [0.03%]
再生医学中ATMPs的当前挑战及未来方向
Fatemeh Abbasi Kakroodi,Elaheh Khodadoust,Marzieh Alizadeh et al.
Fatemeh Abbasi Kakroodi et al.
Advanced therapy medicinal products (ATMPs) represent a groundbreaking category of medications that utilize biological-based products to treat or replace damaged organs. It offers potential solutions for complex diseases through gene therap...
Raheleh Farahzadi,Behnaz Valipour,Ezzatollah Fathi et al.
Raheleh Farahzadi et al.
The length of a telomere provides insight into the replication history of a cell. Notwithstanding the fact that the telomerase enzyme is produced by stem and progenitor cells, a considerable proportion of the documented telomere degradation...
Comparative analysis of the use of autologous exosomes and platelet-derived growth factors in women with premature ovarian insufficiency and infertility: A prospective, randomized, observational, analytical study [0.03%]
自体外泌体和血小板衍化生长因子在卵巢早衰不孕不育患者中应用的比较分析：前瞻性随机观察性分析研究
Carmen Navarro,Pedro Torrecillas Cabrera,Alejandro Teppa Garrán
Carmen Navarro
Stromal fibrosis and ovarian aging depend not only on the age of the patients but also on environmental factors, lifestyle and physiological events such as ovulation itself, which leaves repeated scarring in the ovarian stroma, limiting nor...
Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength [0.03%]
基于包含生长因子的水凝胶微球的脂肪源性干细胞移植可增强肌肉力量
Tomohiro Abe,Emiko Tanaka Isomura,Toshie Kuwahara et al.
Tomohiro Abe et al.
Introduction: Stem cell transplantation is widely employed to treat various diseases, and adipose-derived mesenchymal stem cells (ASCs) are used for allogeneic xenotransplantation. However, muscle function post stem cell ...
Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights [0.03%]
基于富血小板血浆支架的慢性伤口愈合再生潜力：机制、进展和治疗见解
Farag M A Altalbawy,Bilal Abdul Majeed Mukhlif,Ahemad Hussen et al.
Farag M A Altalbawy et al.
Introduction: Chronic wounds such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers often remain trapped in the inflammatory phase due to oxidative stress, protease overactivity, and impaired cellular respon...
Trehalose enhances neuronal differentiation with VEGF secretion in human iPSC-derived neural stem/progenitor cells [0.03%]
海藻糖通过促进人诱导多能干细胞向神经干细胞/祖细胞分化并分泌血管内皮生长因子发挥神经保护作用
Sean K Roose,Yoichi Mizukami,Jun Muto et al.
Sean K Roose et al.
Introduction: Cell transplantation therapy has emerged as a promising approach in regenerative medicine for treating neurological diseases. Neural stem/progenitor cell (NS/PC) transplantation has demonstrated therapeutic ...
Effects and the mechanism of pine pollen polysaccharides on diabetic wound healing in vitro and in vivo [0.03%]
松花多糖对糖尿病创面修复的体内和体外作用及机制研究
Lan Chen,Lifang Zhu,Yu Cao
Lan Chen
Introduction: Pine pollen polysaccharides (PPPS) has anti-inflammatory, immunomodulatory, anti-oxidant, hypoglycemic, and anti-bacterial properties. PPPS can accelerate wound healing in mouse cutaneous wounds, yet it is u...