CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models [0.03%]
基于CRISPR/Cas9的基因组编辑技术在ALS动物模型治疗中的应用
Hamid Khan,Hammad Riaz,Adeel Ahmed et al.
Hamid Khan et al.
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder characterized by the death of motor neurons in the spinal cord and brain regions, leading to a reduced survival rate in patients. Nearly 20 gene mutations are assoc...
Safety and efficacy of long-shelf-life allogeneic adipose-derived mesenchymal stem cell line-derived platelet-like cells for refractory foot ulcers: A translational preclinical and phase 1/2a study [0.03%]
长货架期同种异体脂肪组织来源间充质干细胞系衍生的血小板样细胞治疗难治性足溃疡的安全性和疗效：转化型临床前和I/IIa期研究
Hideaki Obara,Kentaro Matsubara,Naoki Fujimura et al.
Hideaki Obara et al.
Introduction: Refractory foot ulcers, characterized by prolonged healing and frequent recurrences, challenge existing therapies such as revascularization and compression, which typically fail to prevent amputation. We dev...
Stem/progenitor cell dynamics during salivary gland development and regeneration demonstrated by the double pulse-chase paradigm [0.03%]
双脉冲 chase范式证明唾液腺发生和再生过程中干细胞/祖细胞动力学行为
Shusuke Ohshima,Angela Quispe-Salcedo,Hiroko Ida-Yonemochi et al.
Shusuke Ohshima et al.
Introduction: Active and quiescent stem cells coexist in hair follicles and intestinal crypts; however, their localization and differentiation potential in the salivary dynamics are unknown. This study aimed to clarify th...
Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway [0.03%]
丹参酮ⅡA通过Wnt/β-联蛋白途径抑制肩袖损伤中的间质-脂肪祖细胞分化及脂变
Yumei Zhang,Xinghua Li,Rui Zhang et al.
Yumei Zhang et al.
Background: Fibro-adipogenic progenitors (FAPs) contribute to excessive muscular fatty infiltration after rotator cuff tears (RCT), impairing shoulder function. Tanshinone IIA (Tan IIA), a major active compound from Salvi...
From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation [0.03%]
从抗菌剂到促进骨特征的3D打印异质性支架构件：体外和动物模型评估
Shahad Ahmed Daood,Martha Then Xin Yi,Nicole Wen Ce Mun et al.
Shahad Ahmed Daood et al.
This paper describes a promising candidate molecule, investigates the pattern of scaffold composition which arises and assesses the effect of the agent on its mechanical properties. ...
Scalable production process development for NK cells targeting large-scale expansion [0.03%]
针对大规模扩增的NK细胞靶向的生产工艺开发 scalability、生产流程开发过程、NK细胞、大规模扩增
Takuya Kikuchi,Ippei Takeuchi,Hideto Yamaguchi
Takuya Kikuchi
Introduction: Natural Killer (NK) cells have attracted extensive attention as therapeutic agents for hematological malignancies and solid tumors. NK cell therapies carry a lower risk of Graft-Versus-Host Disease (GVHD) in...
Hydrogel in musculoskeletal diseases: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2000 to 2025) [0.03%]
水凝胶在肌肉骨骼疾病中的应用：通过文献计量学解析趋势、研究焦点及未来方向（2000-2025年）
Weibei Sheng,Siyang Cao,Haotian Qin et al.
Weibei Sheng et al.
Introduction: Hydrogels, owing to their excellent biocompatibility, tunable physicochemical properties, and ability to mimic the extracellular matrix, have emerged as promising materials for the treatment of musculoskelet...
Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture [0.03%]
基于三维摇摆培养体系诱导化学转化的犬肝干细胞再分化能力的研究
Kaoruko Kikuchi,Yoko Yamada,Sakurako Neo et al.
Kaoruko Kikuchi et al.
Introduction: Developing canine hepatocyte culture systems is critical for liver transplantation, toxicity evaluation, and drug metabolism studies. However, maintaining viable and functional hepatocytes in long-term cultu...
Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands [0.03%]
通过清除细胞外HMGB1抑制TLR4/RAGE途径可能是放射性唾液腺损伤的治疗靶点
Takashi I,Riho Kanai,Makoto Seki et al.
Takashi I et al.
Introduction: We recently developed a new therapy using effective-mononuclear cells (E-MNCs) and demonstrated its efficacy in treating radiation-damaged salivary glands (SGs). The activity of E-MNCs in part involves const...
Human growth hormone-overexpressing adipose-derived stem cells enhance fibroblast activity and accelerate burn wound healing via ERK pathway therapeutic potential of ADSCs in burn wound repair [0.03%]
高表达人脑生长激素的脂肪源性干细胞通过ERK通路增强成纤维细胞活性并加速烧伤创面修复的治疗潜能
Yang Shao,Mei Han,Guodong Song et al.
Yang Shao et al.
Objective: Human growth hormone (HGH) enhances wound healing by promoting cell proliferation, angiogenesis, and tissue regeneration. This study investigated the effects of HGH-overexpressing Adipose-derived stem cells (HG...