Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine [0.03%]
口腔粘膜上皮细胞刷取法作为再生医学中可移植上皮细胞片源质量控制的一种方法
Yoshiyuki Kasai,Hiroaki Sugiyama,Ryo Takagi et al.
Yoshiyuki Kasai et al.
Autologous oral mucosal epithelial cell sheets have been used for treating epithelial defects such as cornea and esophagus. The cell source of patients' oral mucosal epithelial cell sheet should be examined in normality because it has indiv...
Comparison of capacities to maintain hematopoietic stem cells among different types of stem cells derived from the placenta and umbilical cord [0.03%]
来自胎盘和脐带的不同类型的干细胞维持造血干细胞的能力的比较
Eri Nishikawa,Taro Matsumoto,Mika Isige et al.
Eri Nishikawa et al.
Introduction: Cord blood is utilized as a useful source of cells for hematopoietic stem cell transplantation, but this can be problematic because there is a high rate of graft failure compared to when other graft sources ...
Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies [0.03%]
近期促进诱导多能干细胞再生医学临床应用的政策支持
Kentaro Azuma,Shinya Yamanaka
Kentaro Azuma
In Japan, a research center network consisting of Kyoto University to provide clinical-grade induced Pluripotent Stem Cells (iPSC) and several major research centers to develop iPSC-based regenerative therapies was formed for the clinical a...
Detection of initial angiogenesis from dorsal aorta into metanephroi and elucidation of its role in kidney development [0.03%]
背主动脉向肾原基发生初始血管生成的检测及其在肾脏发育中的作用研究
Yusuke Nishimura,Han-Hsiu Hsu,Pi-Chao Wang
Yusuke Nishimura
Reconstruction of blood vessels is considered the most difficult part for the complicated organs, therefore, blood vessel construction is regarded as a key point for kidney regeneration in vitro. Vasculogenesis and angiogenesis are the two ...
Compassionate use of drugs and medical devices in the United States, the European Union and Japan [0.03%]
美国、欧盟和日本的药物和医疗器械同情使用政策及案例分析
Kenichiro Tsuyuki,Kazuo Yano,Natsumi Watanabe et al.
Kenichiro Tsuyuki et al.
Compassionate use, also called expanded access, provides an important pathway for patients with life-threatening conditions to gain access to unapproved investigational drugs, biologics and medical devices. Although the United States (US) a...
Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1 [0.03%]
携带有KCNQ1基因新突变M437V的长QT综合症病人来源的ips细胞分化的心肌细胞的电生理特性分析
Tatsufumi Sogo,Kumi Morikawa,Yasutaka Kurata et al.
Tatsufumi Sogo et al.
Introduction: Long QT syndrome type 1 (LQT1) is caused by mutations in KCNQ1 coding slowly-activating delayed-rectifier K+ channels. We identified the novel missense mutation M437V of KCNQ1 in a LQT1 patient. Here, we emp...
Priming with erythropoietin enhances cell survival and angiogenic effect of mesenchymal stem cell implantation in rat limb ischemia [0.03%]
缺氧诱导因子途径调节间充质干细胞治疗缺血的有效性及相关细胞因子的分泌
Takuya Mizukami,Yoshitaka Iso,Chisato Sato et al.
Takuya Mizukami et al.
Introduction: Bone marrow mesenchymal stem cells (BMMSCs) ameliorate tissue damage after ischemic injury. Erythropoietin (Epo) has pleiotropic effects in addition to hematopoietic activity. The aim of this study was to in...
Functional peptide KP24 enhances submandibular gland tissue growth in vitro [0.03%]
功能性肽KP24促进下颌下腺组织体外生长
Atsushi Ikeda,Hiroaki Taketa,Gulsan Ara Sathi et al.
Atsushi Ikeda et al.
Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects th...
Masayuki Yamato
Masayuki Yamato
A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions in vitro and harvesting hepatocyte sheets [0.03%]
一种肝细胞片 harvest 和 In vitro 肝功能维持的含肝素结合表皮生长因子样生长因子的肝素修饰温控表面
Yoshinori Arisaka,Jun Kobayashi,Kazuo Ohashi et al.
Yoshinori Arisaka et al.
A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets. A heparin-modified thermoresponsive...