FKBP5/ FKBP51-mediated signaling pathways in neuropsychiatric diseases: Insights for biomarker development and targeted therapies [0.03%]
FKBP5/FKBP51介导的神经精神疾病信号通路：生物标志物开发和靶向治疗的新见解
Yinglong Liu,Jiahe Lian,Youli Fu et al.
Yinglong Liu et al.
The FK506-binding protein 5 gene encodes FKBP51, a molecular chaperone linked to the pathogenesis of neuropsychiatric diseases. Recent evidence shows that FKBP51 modulates activity of the HPA axis and GR-mediated feedback via dynamic intera...
The link between early-life adversity and later alcohol use disorder: A role for microglia? [0.03%]
早期逆境与后期酒精使用障碍之间的联系：小胶质细胞的作用？
Hannah D Lichtenstein,Michelle K Sequeira,Jessica L Bolton
Hannah D Lichtenstein
In the clinical literature, early-life adversity (ELA) has been highly associated with the later development of alcohol misuse and alcohol use disorder (AUD). Adolescence is a period of vulnerability for the development of neuropsychiatric ...
Default mode network connectivity contributes the augment effect stress recovery by natural viewing [0.03%]
默认模式网络连接性有助于自然视图观引起的应激恢复增强效应
Zini Chen,Chanyu Wang,Timothea Toulopoulou et al.
Zini Chen et al.
The psychological benefits of exposure to natural environments are well established. However, whether simply viewing nature images produce similar restorative effects and the brain mechanisms involved remain unclear. For study purposes, we ...
High-intensity interval training improves cognitive dysfunction in chronically stressed mice through alleviating homocysteine-induced transcriptional repression of Cldn5 [0.03%]
高强度间歇训练通过减轻高半胱氨酸诱导的Cldn5转录抑制来改善慢性应激小鼠的认知障碍
Zhao-Xin Sun,Mao-Yang Zhou,Jin-Shan Li et al.
Zhao-Xin Sun et al.
Chronic stress-induced blood-brain barrier (BBB) dysfunction contributes to neurological disorders, with homocysteine (HCY) as a key risk factor. Considering pharmacotherapy limitations, non-invasive interventions like high-intensity interv...
From intracellular sensors to systemic resilience: Reframing the biology of stress [0.03%]
从细胞内感受器到全身抗应激能力：应激生物学的新框架
Jakob Hartmann
Jakob Hartmann
The biological consequences of chronic stress and trauma are complex, influencing multiple systems and contributing to the development of psychiatric disorders such as MDD and PTSD. Yet, the underlying molecular mechanisms that confer susce...
Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats [0.03%]
易感和有弹性的雄性大鼠在杏仁核和海马体中的转录组档案
Kimberly L P Long,Sandra E Muroy,Siamak K Sorooshyari et al.
Kimberly L P Long et al.
Traumatic experiences elicit a wide range of cognitive responses in both humans and animals, leading to diverse outcomes such as enhanced performance, cognitive impairment, or the development of mood and anxiety disorders like posttraumatic...
Sexual dimorphism in anxiety susceptibility: role of PNN maturation timing in the habenulo-interpeduncular reward circuits [0.03%]
焦虑易感性的性别二态性：缰核-中脑导水管周围核奖励环路中Perineuronal网状结构成熟时间的作用
Niels Fjerdingstad,Malalaniaina Rakotobe,Célia Leboulenger et al.
Niels Fjerdingstad et al.
Not just a witness: Highlighting the utility of witness social defeat stress for the examination of neuroimmune-cardiovascular interactions across diverse populations [0.03%]
不仅仅是见证者：探讨见证社会挫败压力对于考察神经免疫-心血管相互作用的实用性以及在不同人群中的应用
Margherita Barbetti,Cora E Smiley,Monia Savi et al.
Margherita Barbetti et al.
Exposure to stress has widespread pathological consequences in terms of neuropsychiatric disorders and cardiovascular disease. Psychosocial stressors represent the most highly impactful and commonly experienced form of stress and, in precli...
Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities [0.03%]
宫内应激诱导短暂的特定GABA能神经元群体的发育变化并导致长期的行为异常
Keren Shoshani-Haye,Gilgi Friedlander,Ofra Golani et al.
Keren Shoshani-Haye et al.
Prenatal stress (PNS) is a well-established risk factor for psychiatric disorders, yet the underlying neurobiological mechanisms remain unclear. Here, we demonstrate that PNS induces long-term behavioral abnormalities, including increased a...
Deep brain stimulation changes locus coeruleus responses to social stress from activation to inhibition [0.03%]
深部脑刺激可将蓝斑对社交压力的反应从激活变为抑制
Sonia Torres-Sanchez,Andre L Curtis,Rita J Valentino et al.
Sonia Torres-Sanchez et al.
Deep Brain Stimulation (DBS) of the subgenual cingulate cortex (SCC) stands as an innovative therapeutic approach for treatment-resistant depression. Previous preclinical investigations utilizing DBS targeted at the ventromedial prefrontal ...