Comparative analysis of multiple chronic unpredictable mild stress paradigms in mice: Behavioural and physiological validity [0.03%]
Ines Erkizia-Santamaría,Luna Fernández,Igor Horrillo et al.
Ines Erkizia-Santamaría et al.
The chronic unpredictable mild stress (CUMS) paradigm is one of the most widely used preclinical models to investigate the role of stress in the neurobiology of depression and to evaluate potential antidepressant therapies, owing to its str...
Early life visceral stress induces auditory brainstem sensitization and cochlear proteomic alterations in a rat model of irritable bowel syndrome [0.03%]
Li-Yuan Zhang,Xing-Li Li,Yuan-Yuan Jing et al.
Li-Yuan Zhang et al.
Early life stress is increasingly recognized as a critical factor shaping neural development and long-term sensory processing. It is also a well-established driver of visceral dysfunction and central to the pathogenesis of irritable bowel s...
Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress [0.03%]
Jeniffer Sanguino-Gómez,Jacobus C Buurstede,Eduardo H L Umeoka et al.
Jeniffer Sanguino-Gómez et al.
Exposure to excessive and/or chronic stressors during early life is a well-established risk factor for later life stress-related mood disorders. Glucocorticoids are often implied as mediators of the long-term effects of early life stress (E...
Integrated brain and body mechanisms underlying acute stress and trauma-related vulnerability [0.03%]
Kar Fye Alvin Lee,Li Liang,Theparambil A Suhail et al.
Kar Fye Alvin Lee et al.
Dysregulated stress response has been linked to multiple health issues, yet the brain and body dynamics of acute stress remain poorly understood. Developing interpretable models is imperative in understanding this complex interplay. The pre...
Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles [0.03%]
Annie Phan,Michael Ru,Brianna Latremouille et al.
Annie Phan et al.
Early life stress (ELS) and adversity influences neurodevelopmental trajectories and affects maturation of brain circuits, network connectivity and epigenetic regulation, leading to increased vulnerability to adult psychopathology. ELS timi...
Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice [0.03%]
不同生命早期应激模型对小鼠发育的影响及其在社会行为中的表现
Vibha A Bapat,Renée C Waters,Ja&#x;nae K Gordon et al.
Vibha A Bapat et al.
In humans, early-life adversity (ELA) predisposes individuals to neuropsychiatric conditions, with different types of adverse experiences linked more strongly to certain maladaptive outcomes. Maternal separation with early weaning (MSEW) an...
Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex [0.03%]
类似社交触摸的触觉刺激通过提高前额叶皮层催产素水平来缓解压力引起的类似焦虑的行为
Mei Liu,Li Ying,Hai Luo et al.
Mei Liu et al.
Stress is a major contributor to the development and exacerbation of anxiety disorders. While social support is known to provide a buffering effect, the specific mechanisms remain poorly understood. This study investigated the neurobiologic...
Gut microbial diversity and inferred capacity to produce short-chain fatty acids are associated with acute stress reactivity in healthy adults [0.03%]
肠道微生物多样性和推测的产生短链脂肪酸的能力与健康成年人急性应激反应相关性研究
Thomas Karner,Paul A G Forbes,David Berry et al.
Thomas Karner et al.
Acute stress triggers the release of stress hormones such as cortisol, increasing stress reactivity and aiding post-stress recovery. Rodent studies revealed that stress reactivity is modulated by the gut microbiota, and few interventional s...
Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment [0.03%]
产后逆境通过选择性地招募注意电路使大鼠产生超警觉的母性状态
Mingyuan Song,Isaac McKie,Allison Su et al.
Mingyuan Song et al.
Maternal caregiving is a central regulator of infant stress physiology and socioemotional development, yet surprisingly little is known about how early-life adversity reshapes the maternal organism itself. Here, we asked how postpartum reso...
Microglial SIRT6 confers protection against neuroinflammation-associated depression through NRF2-HO1 signaling [0.03%]
小胶质细胞SIRT6通过NRF2-HO1信号通路对抗神经炎症相关抑郁的保护作用
Rui Xu,Chi Zhang,Ke Chen et al.
Rui Xu et al.
Microglia-mediated neuroinflammation is widely recognized as a key contributor to various neurological diseases and psychiatric disorders, including depression; however, its underlying mechanisms remain incompletely understood. In this stud...