Central amygdala Fkbp5 expression correlates with faster submission and ethanol self-administration reacquisition: Benztropine reduces ethanol relapse-like reacquisition in stressed rats [0.03%]
中央杏仁核Fkbp5表达与更快的顺从行为和乙醇复吸有关：苯海索可减少应激大鼠中的乙醇复发行为
Luisa B Bertotto,Eleanna M Sakoulas,Marian L Logrip et al.
Luisa B Bertotto et al.
Stress-related emotional disorders, such as post-traumatic stress disorder (PTSD) and major depression, increase alcohol relapse risk. PTSD, depression, and alcohol use phenotypes associate with gene variants of FKBP prolyl isomerase 5 (FKB...
Developmental and early-life stress-induced effects on 5-HT3R-expressing interneurons within auditory cortex [0.03%]
发育和早期生活压力对听觉皮层中5-HT3R表达的中间神经元的影响
James T Moore,Matthew J Sunthimer,Ethan White et al.
James T Moore et al.
Early life stress (ELS) is a well-known predictor of neuropsychiatric disease and contributes to the development of sensory processing deficits that persist throughout life. Organisms are particularly susceptible to the deleterious effects ...
Neuroplacentology of stress: Novel frontiers linking maternal mental health to offspring neurodevelopment [0.03%]
应激的神经胎盘学：连接母体精神健康与子代神经发育的新前沿领域
Cristiana Cruceanu
Cristiana Cruceanu
Neuroplacentology is an emerging interdisciplinary field integrating molecular neuroscience, placental biology, environmental modeling, and single-cell techniques to study stress-related neurodevelopmental programming. The placenta, once co...
Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats [0.03%]
青春期逆境持续诱导雌性大鼠促炎HMGB1信号并破坏基底前脑胆碱能系统
Hayley Ross,Makayla Adelman,Juan E Castillo et al.
Hayley Ross et al.
Adolescence is a critical period of neurodevelopment characterized by heightened neuroplasticity and refinement of executive functioning and cognition. Basal forebrain cholinergic neurons mature during this period, coinciding with developme...
Multi-omics reveals associations between the microbiota-gut-brain axis and antidepressant effects of vagus nerve stimulation [0.03%]
多组学揭示迷走神经刺激的抗抑郁作用与微生物群-肠-脑轴之间的关联
Dan Pan,Mingchen Jiang,Ying Wang et al.
Dan Pan et al.
Background: Major depressive disorder is a severe mental health condition characterized by persistent depressed mood and loss of interest. Current first-line pharmacotherapies often exhibit limited therapeutic performance...
Virtual stress testing: Analyzing endocrine, metabolic, cardiovascular, and psychological responses to the TSST-VR [0.03%]
虚拟压力测试：TSST-VR 的内分泌、代谢、心血管和心理反应分析
Eva Fellinger,Tom Brandt,Andrea Schittenhelm et al.
Eva Fellinger et al.
Background: The Trier Social Stress Test (TSST) is a widely used tool for inducing and measuring stress responses in a controlled environment. In this study, we aimed to explore the effectiveness of a virtual TSST (TSST-V...
Hair stress hormones in individuals with a recent suicide attempt experiencing a depressive episode [0.03%]
近期自杀未遂并伴有抑郁发作的个体头发应激激素水平的研究
Lejla Colic,Anna Karoline Seiffert,Lydia Bahlmann et al.
Lejla Colic et al.
Background: Stressful events and dysregulation of the hypothalamic-pituitary-adrenal (HPA)- axis contribute to the risk of suicide attempt (SA) in persons in depressive episodes. Hair cortisol, cortisone and dehydroepiand...
Age-dependent effects of chronic traumatic and social isolation stress on mice social behavior [0.03%]
慢性创伤和社交隔离压力对小鼠社会行为的影响年龄依赖性效应
Moonseok Choi,Jisu Jeong,Dongsoo Kim et al.
Moonseok Choi et al.
Modern people are exposed to various stressful situations. Stress is a significant factor in emotional changes and social behavior and is associated with imbalances in physiological and psychological homeostasis, including brain function an...
From "Gig" to Genes: The enduring legacy of Seymour Levine in developmental stress neurobiology [0.03%]
从临时工作到基因：Seymour Levine在发育应激神经生物学中的深远影响
Mathias V Schmidt
Mathias V Schmidt
The concept that early life experiences profoundly program adult physiology and behavior is now a cornerstone of neurobiology, a paradigm shift largely founded on the visionary work of Seymour "Gig" Levine. This review traces the intellectu...
Sensitive periods for the link between childhood maltreatment and brain aging during adulthood [0.03%]
儿童虐待与成年后大脑衰老关联的敏感期
Leland L Fleming,Kyoko Ohashi,Michelle Bosquet Enlow et al.
Leland L Fleming et al.
Background: Childhood maltreatment (CM) is associated with the early onset of psychopathology and accelerated biological aging. However, outcomes vary widely among individuals with CM history. This variability may, in par...