USP11 drives stress-induced synaptic structural deficits and depression-like behaviors through GSK3β/mTOR signaling [0.03%]
USP11通过GSK3β/mTOR信号传导驱动压力诱导的突触结构缺陷和类似抑郁的行为
Ningyuan Li,Yuqi Feng,Qian Gong et al.
Ningyuan Li et al.
Major depressive disorder (MDD) is a highly disabling psychiatric condition characterized by profound synaptic dysfunction-particularly in the prefrontal cortex-which constitutes a core neuropathological hallmark of the disease. Nevertheles...
Mathematical modeling of the cortisol stress response to develop indicators that are applicable across studies [0.03%]
数学建模分析皮质醇压力反应以跨研究适用的指标
Laura de Nooij,Jonathan F Posthuma,Robert Miller et al.
Laura de Nooij et al.
Growing interest in interindividual differences in stress neuroendocrinology has created a need to combine data from multiple laboratory acute stress induction studies to allow large-scale individual participant data (IPD) meta-analyses. Ho...
Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory? [0.03%]
从母体到记忆的丘脑室周核促肾上腺皮质激素释放激素输入通路？
Jorge M Mendoza,Amalia Floriou-Servou,Yuncai Chen et al.
Jorge M Mendoza et al.
Thalamic paraventricular nucleus (PVT) neurons expressing the corticotropin releasing hormone receptor 1 (CRHR1) are preferentially activated during early life stress. However, it is unclear how the receptor ligand, the stress-related pepti...
Behavioral phenotype analysis highlights sleep heterogeneity and brain cellular activations in a mouse model of PTSD [0.03%]
行为表型分析揭示了PTSD小鼠模型中的睡眠异质性和大脑细胞活化现象
Emma Lardant,Otilia Kelemen,Louise Pialoux et al.
Emma Lardant et al.
Exposure to intense and unavoidable stressor can lead to Post Traumatic Stress Disorder (PTSD) in some individuals. The heterogeneity of symptom expression, including sleep alterations, may explain the high rate of both non-responder and re...
Central medial and paraventricular thalamic afferents to the orbitofrontal cortex have differential effects on reversal learning [0.03%]
中央中隔丘脑核和视上丘脑核至眶额皮层的投射在不同类型的反应学习中起不同的作用
Kathleen M Tuite,Megan C Ouellette,Milena Girotti et al.
Kathleen M Tuite et al.
Cognitive impairments are prominent in stress-related psychiatric disorders, such as depression and PTSD. While current therapies may improve mood symptoms, many patients experience persistent deficits in cognitive flexibility. One form of ...
Impact of adverse postnatal environment on emotional regulation and neuroimmune function in adolescent rats prenatally exposed to alcohol [0.03%]
孕期酒精暴露后代鼠遭遇不利产后环境时的情绪调节和神经免疫功能的影响
Parker J Holman,Victoria R Vella,Samantha L Baglot et al.
Parker J Holman et al.
Individuals with prenatal alcohol exposure (PAE) are at increased risk for experiencing early-life adversity (ELA), which may contribute to their heightened vulnerability to mental health problems. Using rat models, we examined the independ...
The adrenal is doing what it's supposed to do, you just don't understand it [0.03%]
肾上腺正在做它应该做的事情，你只是不了解而已
Christina Y Cantave,Megan Gunnar
Christina Y Cantave
Exposure to early life adversity is thought to induce long-term alterations in the hypothalamic-pituitary-adrenal (HPA) axis activity and regulation, particularly when such experiences occur during periods of rapid neurodevelopment in early...
Natalie Matosin
Natalie Matosin
Adversity exposure leading to a dysfunctional biological stress response represents a significant risk factor underlying psychiatric disorder aetiology for many individuals. Yet our understanding of how different cell types within stress-re...
Resilience in motion: emerging perspectives on stress, substance use and youth [0.03%]
应激、物质滥用与青年群体的韧性：新兴观点
P Sampedro-Piquero
P Sampedro-Piquero
Adolescence and young adulthood are developmental stages characterized by heightened stress sensitivity and limited cognitive control. The identification of the risk factors of alcohol consumption in these stages is crucial for early interv...
Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues [0.03%]
伏隔核GABA神经元的抑制增强了对习得威胁线索的适当防御反应
Erica M Ramirez,Maricela X Martinez,Ryan K Rokerya et al.
Erica M Ramirez et al.
The ventral pallidum (VP) is embedded within the brain circuits controlling motivated behavior, which are heavily implicated in addiction and other psychiatric disorders. Prior work showed that VP GABAergic neurons (VPGABA) promote reward a...