Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice [0.03%]
不同生命早期应激模型对小鼠发育的影响及其在社会行为中的表现
Vibha A Bapat,Renée C Waters,Ja&#x;nae K Gordon et al.
Vibha A Bapat et al.
In humans, early-life adversity (ELA) predisposes individuals to neuropsychiatric conditions, with different types of adverse experiences linked more strongly to certain maladaptive outcomes. Maternal separation with early weaning (MSEW) an...
Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex [0.03%]
类似社交触摸的触觉刺激通过提高前额叶皮层催产素水平来缓解压力引起的类似焦虑的行为
Mei Liu,Li Ying,Hai Luo et al.
Mei Liu et al.
Stress is a major contributor to the development and exacerbation of anxiety disorders. While social support is known to provide a buffering effect, the specific mechanisms remain poorly understood. This study investigated the neurobiologic...
Gut microbial diversity and inferred capacity to produce short-chain fatty acids are associated with acute stress reactivity in healthy adults [0.03%]
肠道微生物多样性和推测的产生短链脂肪酸的能力与健康成年人急性应激反应相关性研究
Thomas Karner,Paul A G Forbes,David Berry et al.
Thomas Karner et al.
Acute stress triggers the release of stress hormones such as cortisol, increasing stress reactivity and aiding post-stress recovery. Rodent studies revealed that stress reactivity is modulated by the gut microbiota, and few interventional s...
Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment [0.03%]
产后逆境通过选择性地招募注意电路使大鼠产生超警觉的母性状态
Mingyuan Song,Isaac McKie,Allison Su et al.
Mingyuan Song et al.
Maternal caregiving is a central regulator of infant stress physiology and socioemotional development, yet surprisingly little is known about how early-life adversity reshapes the maternal organism itself. Here, we asked how postpartum reso...
Microglial SIRT6 confers protection against neuroinflammation-associated depression through NRF2-HO1 signaling [0.03%]
小胶质细胞SIRT6通过NRF2-HO1信号通路对抗神经炎症相关抑郁的保护作用
Rui Xu,Chi Zhang,Ke Chen et al.
Rui Xu et al.
Microglia-mediated neuroinflammation is widely recognized as a key contributor to various neurological diseases and psychiatric disorders, including depression; however, its underlying mechanisms remain incompletely understood. In this stud...
Norepinephrine neurons in the locus coeruleus and the nucleus of the solitary tract drive different stress-related behavioral outputs in mice [0.03%]
孤束核和蓝斑源去甲肾上腺素神经元调控不同的应激行为反应
Raoni Conceição Dos-Santos,Maria W Najjar,Carly Friedman et al.
Raoni Conceição Dos-Santos et al.
Norepinephrine (NE) is one of the main neuromodulators that regulate the stress response. NE-expressing neurons in the locus coeruleus (LC) and the nucleus of the solitary tract (NTS) project to the corticotropin-releasing hormone (CRH) neu...
Amygdala reactivity to social stress in young adults: A scoping review of neuroimaging studies [0.03%]
年轻人脑成像研究中的社会压力下杏仁核反应性综述研究报告
Maribelle Nassar,Hayat Harati,Elias Estephan et al.
Maribelle Nassar et al.
Introduction: Social stress substantially influences emotional and cognitive functioning and is a key contributor to vulnerability for stress-related psychopathology in young adults. The amygdala plays a central role in m...
Science with Seymour Levine: on glucocorticoid action from birth to senescence [0.03%]
塞尤姆·莱文的科学研究：从出生到衰老的糖皮质激素作用机制
E R de Kloet
E R de Kloet
This tribute to the late Seymour Levine, marking his 100th birth year, highlights the following discoveries in rodents that we had the privilege of sharing with him. (i) Cessation of glucocorticoid receptor (GR) expression in the suprachias...
Transcriptomic analysis of chronic social instability stress during adolescence reveals major shifts in the extracellular matrix [0.03%]
转录组分析发现慢性青春期社会不稳定压力会显著改变细胞外基质
Ming Yin Chu,Luca A Hategan,Amanda M Leonetti et al.
Ming Yin Chu et al.
Adolescence represents a sensitive window of neural plasticity, when social experiences exert enduring influences on emotional and cognitive development. Adverse social conditions, such as social instability stress (SIS), disrupt peer relat...
Environmental enrichment as an intervention to prevent behavioral and neurobiological consequences of maternal separation in rodents: a scope review [0.03%]
环境丰富作为一种干预手段预防母体隔离对啮齿类动物行为和神经生物学影响的范围综述
Natalia Ferreira de Sá,Nadyme Assad,Rosana Camarini et al.
Natalia Ferreira de Sá et al.
Neglectful care or disruption of the mother-infant relationship can alter the offspring's neurodevelopmental trajectory, inducing non-adaptative behaviors and negative neurobiological consequences. Environmental enrichment (EE), in turn, pr...