Sensitive windows, sensitive outcomes: Early or late-postnatal maternal separation differentially impacts puberty and behavior [0.03%]
敏感窗口，敏感结果：产后早期或晚期分离对青春期和行为的不同影响
Angarika Balakrishnan,Prabarna Ganguly,Sheta Roy et al.
Angarika Balakrishnan et al.
Early-life adversity disrupts the maturation of neuroendocrine, cognitive, and emotional regulatory systems, yet outcomes likely depend on both the timing of development and sex. Maternal separation (MS) in rodents is a widely used model fo...
Early-life adversity in rodents: Experimental design is of the essence [0.03%]
论点：啮齿动物早期生活压力的研究：实验设计至关重要
Rixt van der Veen,Marian Joëls,Aniko Korosi
Rixt van der Veen
Early-life adversity (ELA) is a well-documented risk factor for the development of psychiatric illnesses. Prospective investigations in humans are complex and limited in their ability to study the underlying neurobiological mechanisms, whic...
Brain network centrality following stress in adults with major depressive disorder and childhood trauma [0.03%]
童年创伤和成人抑郁症患者在压力下的大脑网络中枢性下降
C Broeder,J M Pasteuning,T A A Broeders et al.
C Broeder et al.
Background: Childhood trauma (CT) is a major risk factor for major depressive disorder (MDD), potentially via altered stress system development. Previous studies have shown stress-related changes in brain network function...
Alterations of microRNAs across human and mouse limbic brain areas: molecular mechanisms and biological processes involved in major depressive disorder [0.03%]
人类和小鼠边缘叶脑区微小核糖核酸的改变：抑郁症相关的分子机制及生物学过程
Samantha Saleri,Moira Marizzoni,Patrizia Genini et al.
Samantha Saleri et al.
The etiology of major depressive disorder (MDD) is multifactorial with both genetic and environmental factors, such as adverse/stressful life events, contributing to risk. There is some evidence suggesting that microRNAs (miRNAs) mediate en...
The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder [0.03%]
儿童期虐待通过促炎症反应和犬尿酸途径与一生中的物质使用障碍之间的关联研究
Lars Östman,Elisabeth R Paul,He Zhang et al.
Lars Östman et al.
Introduction: Childhood maltreatment (CM) is a risk factor for adult psychiatric and substance use disorders (SUD). Retrospectively assessed CM has been linked to increased proinflammatory cytokines, including IL-6. Induc...
Comparative analysis of multiple chronic unpredictable mild stress paradigms in mice: Behavioural and physiological validity [0.03%]
小鼠多种慢性轻度不可预测应激模型的行为和生理有效性的比较分析
Ines Erkizia-Santamaría,Luna Fernández,Igor Horrillo et al.
Ines Erkizia-Santamaría et al.
The chronic unpredictable mild stress (CUMS) paradigm is one of the most widely used preclinical models to investigate the role of stress in the neurobiology of depression and to evaluate potential antidepressant therapies, owing to its str...
Early life visceral stress induces auditory brainstem sensitization and cochlear proteomic alterations in a rat model of irritable bowel syndrome [0.03%]
早期生命期的内脏压力可诱导易激惹结肠综合征大鼠模型听脑干过度兴奋及耳蜗蛋白质组变化
Li-Yuan Zhang,Xing-Li Li,Yuan-Yuan Jing et al.
Li-Yuan Zhang et al.
Early life stress is increasingly recognized as a critical factor shaping neural development and long-term sensory processing. It is also a well-established driver of visceral dysfunction and central to the pathogenesis of irritable bowel s...
Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress [0.03%]
早年生活压力影响小鼠海马脑区一致的基因表达模式尽管个别基因表达存在较大个体差异
Jeniffer Sanguino-Gómez,Jacobus C Buurstede,Eduardo H L Umeoka et al.
Jeniffer Sanguino-Gómez et al.
Exposure to excessive and/or chronic stressors during early life is a well-established risk factor for later life stress-related mood disorders. Glucocorticoids are often implied as mediators of the long-term effects of early life stress (E...
Integrated brain and body mechanisms underlying acute stress and trauma-related vulnerability [0.03%]
应激和创伤脆弱性相关的脑体整合机制研究进展
Kar Fye Alvin Lee,Li Liang,Theparambil A Suhail et al.
Kar Fye Alvin Lee et al.
Dysregulated stress response has been linked to multiple health issues, yet the brain and body dynamics of acute stress remain poorly understood. Developing interpretable models is imperative in understanding this complex interplay. The pre...
Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles [0.03%]
早期应激改变大鼠幼崽的神经发育里程碑以及小鼠青少年时期的运动皮质形态和步态
Annie Phan,Michael Ru,Brianna Latremouille et al.
Annie Phan et al.
Early life stress (ELS) and adversity influences neurodevelopmental trajectories and affects maturation of brain circuits, network connectivity and epigenetic regulation, leading to increased vulnerability to adult psychopathology. ELS timi...