Proenkephalin neurons in the adBNST mitigate stress-induced anxiety and estrous cycle disruption in female mice [0.03%]
雄性小鼠腹侧床核前阿片肽原神经元在应激诱发的焦虑和发情周期紊乱中的作用
Wenwen Su,Yongxiu Song,Xia Zhang et al.
Wenwen Su et al.
Chronic stress is a major risk factor for anxiety disorders and is often accompanied by disruptions in female reproductive cyclicity, but the stress-responsive neural populations that shape these comorbid behavioral and physiological outcom...
Temporal reorganization of maternal care during early life stress in mice [0.03%]
小鼠早期生活应激下的母性照料的时序重构
Hannah Jo,Eman Ali,Catherine Jensen Peña
Hannah Jo
Maternal separation is a widely used early-life stress (ELS) paradigm in rodents. Disrupted maternal care by separation of pups from the dam for several hours per day across neonatal and juvenile development has been found to alter hypothal...
Prelimbic cortex-associated stress sensitisation and region-specific mitochondrial adaptations across preclinical approaches relevant to PTSD and depression [0.03%]
与PTSD和抑郁症相关的跨临床前方法的前扣带回皮层相关压力敏感化和区域特异性线粒体适应性
Charlotte S Rye,Laetitia H E Ward,Clara Velázquez-Sánchez et al.
Charlotte S Rye et al.
Mitochondrial dysfunction is increasingly implicated in stress-related disorders, including post-traumatic stress disorder (PTSD) and depression, but its relationship to inflammatory signalling and circuit-level vulnerability remains unclea...
Effects of early life adversity on acute metabolic outcomes during neonatal development [0.03%]
早年逆境对新生儿期急性代谢结果的影响
Hannah E Lapp,Melissa G Salazar,Evelyn Deveraux et al.
Hannah E Lapp et al.
Early life adversity has lasting effects on neuroendocrine function and increases risk for psychopathology and metabolic disease. Stress and metabolism are closely intertwined, with critical periods for early life stress overlapping those f...
Regular intake of caffeinated but not decaffeinated coffee attenuates behavioral modifications in mice subject to chronic unpredictable stress [0.03%]
定期饮用含咖啡因而非不含咖啡因的咖啡可缓解慢性不可预测压力小鼠的行为改变
Ângelo R Tomé,Nuno J Machado,Ana Paula Ardais et al.
Ângelo R Tomé et al.
The regular intake of moderate doses of coffee is increasingly recognized as a lifestyle factor associated with a lower incidence of depressive-like conditions; however, there is still a debate on the relative effects of caffeinated and dec...
Michael J Meaney
Michael J Meaney
This essay assumes an historical perspective intended to highlight the major contributions of Seymour "Gig" Levine to the conceptual scaffold that guides so much of the current research in development and psychopathology. I suggest that per...
Activity of VMS-projecting mPFC neurons encodes individual vulnerability to chronic restraint stress in male mice [0.03%]
雄性小鼠慢性束缚应激易感性的神经编码
Yaqiu Tang,Xin Gong,Mengyu Dai et al.
Yaqiu Tang et al.
The medial prefrontal cortex (mPFC) is critically involved in stress-related behaviors, specifically via the subpopulation of neurons that project to the ventromedial striatum (VMS). However, whether VMS-projecting mPFC neurons contribute t...
Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood [0.03%]
人际关系压力、炎症表观遗传学指标及抑郁症状：来自青少年到青年期的纵向联系
Stefanos Mastrotheodoros,Winni Schalkwijk,Michelle de Groot et al.
Stefanos Mastrotheodoros et al.
Background: Adolescent interpersonal stress increases depression risk, and chronic low-grade inflammation may act as a potential underlying biological mechanism. ...
NMDA receptor-dependent structural plasticity links early life stress to persistent aggression [0.03%]
NMDAR依赖的结构可塑性连接早期生活压力与持久攻击行为
Jessica T Jacobs,Jacob C Nordman
Jessica T Jacobs
Early life stress (ELS) is a major risk factor for reactive and pathological aggression that can persist long after the original stress exposure. Across species, ELS produces enduring alterations in the neural circuits that regulate social ...
Future Leaders in Stress: the next generation of stress neurobiology [0.03%]
应激领域的未来领导者——下一代应激神经生物学研究
Jessica L Bolton,Natalie Matosin
Jessica L Bolton