Osteogenic differentiation of gingival and periodontal ligament fibroblasts inhibits osteoclast formation in 2D and 3D fibrin cultures [0.03%]
牙龈和牙周膜成纤维细胞的成骨分化可抑制二维和三维纤维蛋白培养中的破骨细胞形成
Merve Ceylan,Teun J de Vries,Wendy J A M Runderkamp et al.
Merve Ceylan et al.
Bone regeneration requires coordinated interactions between multiple cell types responding to biochemical and biomechanical cues from the extracellular matrix (ECM). Gingival fibroblasts (GFs) and periodontal ligament fibroblasts (PDLFs) co...
Stan Tuijp,Marc Meijer,Ineke D C Jansen
Stan Tuijp
Local anesthetics such as lidocaine have anti-inflammatory effects. However, the anti-inflammatory mechanism remains vague, but phagocytosis, migration, exocytosis, cellular metabolism and cellular pH levels seem to be affected. During COVI...
Sost deficiency leads to greater bone vascular porosity, but similar osteocyte lacunar properties with increasing age [0.03%]
ソストの欠如により年齢が高まると骨血管の孔隙率は上昇するも、osteocyte lacunaeの性質に影響なし
Taylor deVet,Anthony Helou,Sara Checa et al.
Taylor deVet et al.
Sclerostin neutralizing antibody is an approved anabolic drug used to increase bone mass. Numerous preclinical studies examined bone mass and microstructural changes in mice receiving sclerostin neutralizing antibodies or mice lacking scler...
Persistent postnatal IGF2 expression alters adult skeletal architecture in Igf2 G/A mice [0.03%]
Igf2 G/A小鼠中持续的出生后IGF2表达改变了成年骨骼的结构
Shady Younis,Anika Shimonty,Samantha Perez-Menendez et al.
Shady Younis et al.
Background: IGF2 is an imprinted growth factor essential for fetal development. A single nucleotide variation at a conserved ZBED6 binding site within Igf2 intron 3 induces post-natal IGF2 expression and resulted in incre...
Extending the global landscape of Bruck syndrome: Case series of Indonesian and Ukrainian patients with PLOD2 pathogenic variants and literature review [0.03%]
Bruck综合征的全球发病情况扩展：PLOD2致病突变的印度尼西亚和乌克兰患者的病例系列及文献综述
Devina Afraditya Paveta,Agustini Utari,Ferdy Kurniawan Cayami et al.
Devina Afraditya Paveta et al.
Bruck syndrome type 2 (BRKS2) is a rare disorder marked by congenital joint contractures and bone fragility, caused by variants in PLOD2, which encodes lysyl hydroxylase 2 essential for collagen stability. We report the first genetically co...
Case Reports
Bone reports. 2026 Jul 7:30:101938. DOI:10.1016/j.bonr.2026.101938 2026
Impact of early life stress on the immune response and bone regeneration after fracture [0.03%]
早期压力对骨折后免疫反应和骨再生的影响
Dorothea Gebauer,Tamara Schimmele,Dominik Langgartner et al.
Dorothea Gebauer et al.
Early-life stress (ELS) constitutes an enormous socio-economic burden and is an acknowledged risk factor for the development of several affective and somatic conditions, including bone disorders. However, its effects on bone fracture healin...
Bone transcriptomics reveals that juzentaihoto remodels and activates multiple pathways in Klotho-deficient mice [0.03%]
骨转录组学揭示了益气养血方通过重塑和激活克罗托缺陷型小鼠的多条信号通路发挥药效
Akiko Maruko,Kenshiro Oshima,Akinori Nishi et al.
Akiko Maruko et al.
Background: Aging-related osteoporosis arises from an imbalance between bone formation and resorption. The traditional Japanese Kampo formula juzentaihoto (JTT) is used in the clinic to improve imbalances in systemic home...
Preventing muscle and bone loss in peri-menopausal and early post-menopausal females with heavy strength and impact training: Results from the STOP-EM randomised waitlisted controlled feasibility trial [0.03%]
高强度和冲击力锻炼预防围绝经期和早期绝经后女性肌肉骨骼丢失：来自STOP-EM随机对照试验的结果
Patrick W Whitman,Christina J Alexander,Leah Kaluta et al.
Patrick W Whitman et al.
Purpose: During the menopausal transition, female individuals experience declines in bone health. Menopausal female individuals also lose lean mass due to aging; however, few exercise trials have included peri- and early ...
MRONJ risk associated with combined antiresorptive and vascular endothelial growth factor receptor tyrosine kinase inhibitors [0.03%]
抗吸收剂和血管内皮生长因子受体酪氨酸激酶抑制剂联合使用的MRONJ风险
G Mammone,R Coropciuc,T Van den Wyngaert et al.
G Mammone et al.
Background: Concomitant use of vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) and bone resorption inhibitors (BRIs) may increase the risk of medication-related osteonecrosis of the jaw...
Individualized antiresorptive therapy in fibrous dysplasia and McCune-Albright syndrome: A retrospective cohort study [0.03%]
纤维结构不良和McCune-Albright综合征的个体化抗吸收治疗：一项回顾性队列研究
Tonio Lipkow,Mikolaj Bartosik,Johann Sprick-Schütte et al.
Tonio Lipkow et al.
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare benign bone disorder caused by postzygotic mutations in GNAS, characterized by skeletal lesions leading to pain, deformities, and fractures. Although antiresorptive agents such a...