Macrophage modulation by polymerized hemoglobins: Potential as a wound-healing therapy [0.03%]
聚合血红蛋白对巨噬细胞的调节：作为潜在的伤口愈合疗法
Paulina Krzyszczyk,Kishan Patel,Yixin Meng et al.
Paulina Krzyszczyk et al.
Chronic skin wounds are hypoxic and are stalled in a pro-inflammatory state. Hemoglobin (Hb)-based oxygen carriers have shown potential in increasing oxygen delivery to aid wound healing. Macrophages also take up Hb, thus altering their phe...
Omar Haque,Casie A Pendexter,Stephanie E J Cronin et al.
Omar Haque et al.
Ex-vivo liver perfusion (EVLP) is an ideal platform to study liver disease, therapeutic interventions, and pharmacokinetic properties of drugs without any patient risk. Rat livers are an ideal model for EVLP due to less organ quality variab...
First-in-human evaluation of a hand-held automated venipuncture device for rapid venous blood draws [0.03%]
一次性 handheld 自动穿刺装置的首次人体研究用于快速静脉抽血
Josh M Leipheimer,Max L Balter,Alvin I Chen et al.
Josh M Leipheimer et al.
Obtaining venous access for blood sampling or intravenous (IV) fluid delivery is an essential first step in patient care. However, success rates rely heavily on clinician experience and patient physiology. Difficulties in obtaining venous a...
A protein interaction free energy model based on amino acid residue contributions: Assessment of point mutation stability of T4 lysozyme [0.03%]
基于氨基酸残基对的蛋白质相互作用自由能模型及T4溶菌酶单点突变稳定性的评估
Lawrence J Williams,Brian J Schendt,Zachary R Fritz et al.
Lawrence J Williams et al.
Here we present a model to estimate the interaction free energy contribution of each amino acid residue of a given protein. Protein interaction energy is described in terms of per-residue interaction factors, μ. Multibody interactions are ...
Real-time measurement of cholesterol secreted by human hepatocytes using a novel microfluidic assay [0.03%]
一种新型微流体装置实时测量人肝细胞分泌胆固醇的方法研究
Sonali Karnik,Chaeeun Lee,Andrea Cancino et al.
Sonali Karnik et al.
The use of microfluidics has become widespread in recent years because of the use of lesser resources such as small size, low volume of reagents, and physiological representation of mammalian cells. One of the advantages of microfluidic-bas...
Exploring donor demographics effects on hepatocyte yield and viability: Results of whole human liver isolation from one center [0.03%]
供体人口统计学特征对肝细胞产量和活力的影响：单中心全人肝分离结果分析
Sharon Geerts,Sinan Ozer,Chris Chu et al.
Sharon Geerts et al.
Due to the growth of cell-based therapeutic alternatives addressing the shortage of livers for transplant, there is necessity for a reliable source of human hepatocytes. In addition, pharmaceutical research often requires human hepatocytes ...
Yibin Chen,Julie Devalliere,Beyza Bulutoglu et al.
Yibin Chen et al.
Engineered liver grafts for transplantation with sufficient hepatic function have been developed both in small and large animal models using the whole liver engineering approach. However, repopulation of the bile ducts in the whole liver sc...
Yibin Chen,Julie Devalliere,Beyza Bulutoglu et al.
Yibin Chen et al.
Engineered liver grafts for transplantation with sufficient hepatic function have been developed both in small and large animal models using the whole liver engineering approach. However, repopulation of the bile ducts in the whole liver sc...
A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion [0.03%]
一种新颖的模型：在亚正常温度机械灌注后的离体肝再灌注
James H Avruch,Bote G Bruinsma,Pepijn D Weeder et al.
James H Avruch et al.
Machine perfusion-based organ preservation techniques are prudently transitioning into clinical practice. Although experimental data is compelling, the outcomes in the highly variable clinical donation-transplantation setting are unpredicta...
The growing role of precision and personalized medicine for cancer treatment [0.03%]
精准与个性化医疗在癌症治疗中的作用日益增大
Paulina Krzyszczyk,Alison Acevedo,Erika J Davidoff et al.
Paulina Krzyszczyk et al.
Cancer is a devastating disease that takes the lives of hundreds of thousands of people every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only a subset of the patient populati...