Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR [0.03%]
单光子雪崩二极管地下荧光激光雷达传感器
Petr Bruza,Arthur Petusseau,Arin Ulku et al.
Petr Bruza et al.
We realized subsurface fluorescence LiDAR with a large format single-photon avalanche diode array capable of localizing and quantifying concentration of fluorescent molecules in heavily scattering media, such as tissue, with submillimeter d...
Jeongsoo Kim,Shwetadwip Chowdhury
Jeongsoo Kim
In optical diffraction tomography (ODT), a sample's 3D refractive index (RI) is often reconstructed after illuminating it from multiple angles, with the assumption that the sample remains static throughout data collection. When the sample u...
Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors [0.03%]
纳米柱光子晶体生物传感器的超高灵敏度阿尔茨海默氏症生物标志物检测技术
Guilherme S Arruda,Katie Morris,Augusto Martins et al.
Guilherme S Arruda et al.
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for biomarker tests that can be readily used by practitioners. Although biomarker detection directly in patients' blood is now possible, ...
Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video rate [0.03%]
全场宽视野分子键选择荧光成像：从单分子到超越视频速率的细胞成像
Dongkwan Lee,Haomin Wang,Philip A Kocheril et al.
Dongkwan Lee et al.
Wide-field (WF) imaging is pivotal for observing dynamic biological events. While WF chemical microscopy offers high molecular specificity, it lacks the sensitivity for single-molecule detection. In contrast, WF fluorescence microscopy prov...
Label-free multimodal polarization-sensitive optical microscope for multiparametric quantitative characterization of collagen [0.03%]
一种无标签多模态偏振敏感光学显微镜用于定量表征胶原蛋白的多种参数
Lingxiao Yang,Rishyashring R Iyer,Janet E Sorrells et al.
Lingxiao Yang et al.
Collagen is an essential component of biological tissues with a variety of subtypes. To be able to capture these subtypes, fully exploit the polarization-sensitive light-collagen interactions, and provide comprehensive information of collag...
Yongyi Zhao,Sean M Farrell,Christian R Jacobson et al.
Yongyi Zhao et al.
Optics that allow us to see clearly along one viewing direction while obscuring others' view of us are useful in numerous settings, including privacy-preserving window screens and one-way mirrors for psychological studies. Additionally, due...
Adaptive point-scan imaging beyond the frame rate-resolution limit with scene-reactive scan trajectories [0.03%]
具有场景反应式扫描轨迹的超帧频分辨率限制的自适应点扫成像技术
Mark Draelos,Christian Viehland,Ryan P Mcnabb et al.
Mark Draelos et al.
Point-scanned imaging modalities, such as optical coherence tomography (OCT), are subject to frame rate limits governed by image resolution, sampling rate, and scanner dynamics. For scenes with dynamic features on static backgrounds, adapti...
High-speed 4D fluorescence light field tomography of whole freely moving organisms [0.03%]
对整个自由活动生物进行高速四维荧光光场层析成像
Kevin C Zhou,Clare Cook,Archan Chakraborty et al.
Kevin C Zhou et al.
Volumetric fluorescence imaging techniques, such as confocal, multiphoton, light sheet, and light field microscopy, have become indispensable tools across a wide range of cellular, developmental, and neurobiological applications. However, i...
Exploring the structure, metabolism, and biochemistry of the neuronal microenvironment label-free using fast simultaneous multimodal optical microscopy [0.03%]
利用快速多模光学显微镜无标签探索神经元微环境的结构、代谢及生化反应
Rishyashring R Iyer,Janet E Sorrells,Lingxiao Yang et al.
Rishyashring R Iyer et al.
The technologies to examine the neuronal microenvironment label free remain critically underexplored. There is a gap in our knowledge of underlying metabolic, biochemical, and electrophysiological mechanisms behind several neurological proc...
Enhanced biochemical sensing with high-Q transmission resonances in free-standing membrane metasurfaces [0.03%]
自由悬浮膜型超表面的高Q传输共振生化传感增强效应
Samir Rosas,Wihan Adi,Aidana Beisenova et al.
Samir Rosas et al.
Optical metasurfaces provide novel solutions to label-free biochemical sensing by localizing light resonantly beyond the diffraction limit, thereby selectively enhancing light-matter interactions for improved analytical performance. However...