Maskless and on-chip LED-array microscope with spatially varying angle calibration for centimeter-scale phase imaging [0.03%]
无掩模芯片LED阵列显微镜通过空间变化角度校准实现厘米尺度相位成像
Sibi Chakravarthy Shanmugavel,Vindya Senanayake,Donghwa Suh et al.
Sibi Chakravarthy Shanmugavel et al.
Conventional lens-based microscopes are constrained by a trade-off between resolution and field-of-view (FOV), which limits overall imaging throughput. Recent works have shown that on-chip imaging systems with LED-array-based illumination o...
Single-scan adaptive optics-enabled quantitative optical coherence tomography angiography for absolute three-dimensional retinal blood flow mapping [0.03%]
单扫描自适应光学增强型定量光 coherence 干涉断层扫描血管造影术在绝对三维视网膜血流图绘制中的应用
Achyut J Raghavendra,Osamah J Saeedi,Daniel X Hammer et al.
Achyut J Raghavendra et al.
Accurate measurement of blood flow is critical for understanding metabolic function and disease progression, particularly in the retina, where conditions such as diabetic retinopathy, macular degeneration, and glaucoma are closely linked to...
Longitudinal, label-free, high-resolution imaging of glioblastoma spheroid response to therapy: a translational tool for preclinical evaluation of chemotherapy, radiation, and immunotherapy [0.03%]
胶质母细胞瘤类器官对化疗、放疗和免疫治疗反应的纵向、无标记、高分辨率成像：临床前评估的转化工具
Caroline E Serafini,Amin Davarzani,Dan Cappabianca et al.
Caroline E Serafini et al.
Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options and poor patient survival, underscoring the need for novel, to our knowledge, therapeutic strategies and improved preclinical models. Patient-derived tumor spher...
Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy in vivo enabled by absorbing dye molecules [0.03%]
吸收染料分子在体内增强光学相干层析和光声显微镜的穿透深度
David A Miller,Yirui Xu,Robert Highland et al.
David A Miller et al.
The scattering and absorption of light within biological tissue severely limits the penetration depth of optical imaging techniques. Recently, it has been found that water-soluble, strongly absorbing dye molecules, such as tartrazine, can a...
Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR [0.03%]
单光子雪崩二极管地下荧光激光雷达传感器
Petr Bruza,Arthur Petusseau,Arin Ulku et al.
Petr Bruza et al.
We realized subsurface fluorescence LiDAR with a large format single-photon avalanche diode array capable of localizing and quantifying concentration of fluorescent molecules in heavily scattering media, such as tissue, with submillimeter d...
Jeongsoo Kim,Shwetadwip Chowdhury
Jeongsoo Kim
In optical diffraction tomography (ODT), a sample's 3D refractive index (RI) is often reconstructed after illuminating it from multiple angles, with the assumption that the sample remains static throughout data collection. When the sample u...
Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors [0.03%]
纳米柱光子晶体生物传感器的超高灵敏度阿尔茨海默氏症生物标志物检测技术
Guilherme S Arruda,Katie Morris,Augusto Martins et al.
Guilherme S Arruda et al.
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for biomarker tests that can be readily used by practitioners. Although biomarker detection directly in patients' blood is now possible, ...
Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video rate [0.03%]
全场宽视野分子键选择荧光成像：从单分子到超越视频速率的细胞成像
Dongkwan Lee,Haomin Wang,Philip A Kocheril et al.
Dongkwan Lee et al.
Wide-field (WF) imaging is pivotal for observing dynamic biological events. While WF chemical microscopy offers high molecular specificity, it lacks the sensitivity for single-molecule detection. In contrast, WF fluorescence microscopy prov...
Label-free multimodal polarization-sensitive optical microscope for multiparametric quantitative characterization of collagen [0.03%]
一种无标签多模态偏振敏感光学显微镜用于定量表征胶原蛋白的多种参数
Lingxiao Yang,Rishyashring R Iyer,Janet E Sorrells et al.
Lingxiao Yang et al.
Collagen is an essential component of biological tissues with a variety of subtypes. To be able to capture these subtypes, fully exploit the polarization-sensitive light-collagen interactions, and provide comprehensive information of collag...
Yongyi Zhao,Sean M Farrell,Christian R Jacobson et al.
Yongyi Zhao et al.
Optics that allow us to see clearly along one viewing direction while obscuring others' view of us are useful in numerous settings, including privacy-preserving window screens and one-way mirrors for psychological studies. Additionally, due...