Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles [0.03%]
迷走神经刺激对心率和喉肌影响的测定及建模研究
William J Huffman,Eric D Musselman,Nicole A Pelot et al.
William J Huffman et al.
Background: Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated with therapy for heart failure, but stimulation frequency and amplitude are limited by patient tolerance. An understanding of physiolo...
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration? [0.03%]
COVID-19后综合征是乙酰胆碱神经调节障碍吗？对尼古丁治疗有反应
Marco Leitzke
Marco Leitzke
Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. S...
A radiographic, deep transfer learning framework, adapted to estimate lung opacities from chest x-rays [0.03%]
用于估计胸部X光片中肺部混浊的放射性深度转移学习框架
Avantika Vardhan,Alex Makhnevich,Pravan Omprakash et al.
Avantika Vardhan et al.
Chest radiographs (CXRs) are the most widely available radiographic imaging modality used to detect respiratory diseases that result in lung opacities. CXR reports often use non-standardized language that result in subjective, qualitative, ...
Sympathetic innervation of human and porcine spleens: implications for between species variation in function [0.03%]
人和猪脾的交感神经支配：功能种间差异的启示
Logan G Kirkland,Chloe G Garbe,Joseph Hadaya et al.
Logan G Kirkland et al.
Background: The vagus nerve affects innate immune responses by activating spleen-projecting sympathetic neurons, which modulate leukocyte function. Recent basic and clinical research investigating vagus nerve stimulation ...
Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines [0.03%]
迷走神经刺激与炎症：超越细胞因子的范围
Aidan Falvey
Aidan Falvey
Approximately 20 years ago it was discovered that the vagus nerve regulates pro-inflammatory cytokine levels and inflammation. Subsequent research using several preclinical models revealed that vagus nerve stimulation evokes a protective de...
A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia [0.03%]
[11C]PBR28和[18F]FDG微小PET评估鼠源内毒素血症的神经炎症和脑能量代谢
Santhoshi P Palandira,Joseph Carrion,Lauren Turecki et al.
Santhoshi P Palandira et al.
Background: Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments....
Akhil Jain,Isobel Jobson,Michaela Griffin et al.
Akhil Jain et al.
Background: Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTField...
High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain [0.03%]
高强度电刺激可减轻神经元释放炎症介质并缓解神经病理性疼痛
Huan Yang,Timir Datta-Chaudhuri,Sam J George et al.
Huan Yang et al.
Background: Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In precl...
Marco P Soares Dos Santos,Rodrigo M C Bernardo
Marco P Soares Dos Santos
The concept of Instrumented Smart Implant emerged as a leading research topic that aims to revolutionize the field of orthopaedic implantology. These implants have been designed incorporating biophysical therapeutic actuation, bone-implant ...
Effect of uniform capacitively coupled electric fields on matrix metabolism of osteoarthritic cartilage [0.03%]
均匀电容耦合电场对骨关节炎软骨基质代谢的影响研究
Kaleb Noruzi,Pooja Swami,Lidia Frejo et al.
Kaleb Noruzi et al.
Background: Osteoarthritis (OA) is a common and debilitating condition characterized by degeneration of hyaline cartilage. Currently, there is no treatment for OA that directly targets degradation of cartilage matrix. Cap...