A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation [0.03%]
一种柔软、可扩展且适用于靶向周围神经调节的多接触袖状电极
Valentina Paggi,Florian Fallegger,Ludovic Serex et al.
Valentina Paggi et al.
Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in disc...
McGregor Joyner,Sheng-Hsiou Hsu,Stephanie Martin et al.
McGregor Joyner et al.
Background: Seizure detection is challenging outside the clinical environment due to the lack of comfortable, reliable, and practical long-term neurophysiological monitoring devices. We developed a novel, discreet, unobst...
Nigel Paul Pedersen,Raul Castillo Astorga
Nigel Paul Pedersen
The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect of non-invasive stimulation of ...
Evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation in an experimental model of neuropathic pain in rats [0.03%]
大鼠神经病理性疼痛实验模型中通过诱发复合动作电位(ECAP)控制的脊髓刺激闭环系统
Eline M Versantvoort,Birte E Dietz,Dave Mugan et al.
Eline M Versantvoort et al.
Background: Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound action potential (ECAP) represents a measure of d...
Beyond pediatrics: noninvasive spinal neuromodulation improves motor function in an adult with cerebral palsy [0.03%]
超越儿科：无创脊髓神经调节改善了一位成年脑瘫患者的运动功能
Rahul Sachdeva,Kristin Girshin,Yousef Shirkhani et al.
Rahul Sachdeva et al.
Regaining motor function in individuals with cerebral palsy (CP) has been predominantly studied in children, resulting in an underrepresentation of adults in research efforts. We tested the efficacy of noninvasive spinal neuromodulation wit...
Samuel Martínez-Meza,Bhavya Singh,Douglas F Nixon et al.
Samuel Martínez-Meza et al.
Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in the body, and partially innervates hepatic functionality through the liver-brain ...
Keren Powell,Kanheng Lin,Willians Tambo et al.
Keren Powell et al.
Nearly 5 decades ago, the effect of trigeminal nerve stimulation (TNS) on cerebral blood flow was observed for the first time. This implication directly led to further investigations and TNS' success as a therapeutic intervention. Possessin...
Dafni Carmina,Valentina Benfenati,Claudia Simonelli et al.
Dafni Carmina et al.
The increasing prevalence of chronic diseases is a driver for emerging big data technologies for healthcare including digital platforms for data collection, systems for active patient engagement and education, therapy specific predictive mo...
Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment? [0.03%]
非侵入性迷走神经刺激：炎症性肠病治疗的未来？
Bruno Bonaz
Bruno Bonaz
The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve stimulation (VNS) in adult patie...
Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders [0.03%]
非侵入性神经调控：胃肠疾病内脏痛的新兴干预措施
Md Jahangir Alam,Jiande D Z Chen
Md Jahangir Alam
Gastrointestinal (GI) disorders, which extend from the esophagus to the anus, are the most common diseases of the GI tract. Among these disorders, pain, encompassing both abdominal and visceral pain, is a predominant feature, affecting the ...