Andrea Stofkova,Masaaki Murakami
Andrea Stofkova
The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB) and blood-retina barrier (BRB) respectively, which create a physical interface that tightly contro...
Neuroimmunomodulation of tissue injury and disease: an expanding view of the inflammatory reflex pathway [0.03%]
组织损伤与疾病的神经免疫调节：炎症反射路径的扩大视角
Shinji Tanaka,Benjamin Hammond,Diane L Rosin et al.
Shinji Tanaka et al.
Neuroimmunomodulation through peripheral nerve activation is an important therapeutic approach to various disorders. Central to this approach is the inflammatory reflex pathway in which the cholinergic anti-inflammatory pathway represents t...
Non-invasive treatment of patients with upper extremity spasticity following stroke using paired trans-spinal and peripheral direct current stimulation [0.03%]
经颅脊髓电刺激治疗卒中后上肢痉挛性瘫痪患者
Alexandra Paget-Blanc,Johanna L Chang,Maira Saul et al.
Alexandra Paget-Blanc et al.
Background: Muscle spasticity is a common impediment to motor recovery in patients with chronic stroke. Standard-of-care treatments such as botulinum toxin injections can temporarily relieve muscle stiffness and pain asso...
Neurorestorative interventions involving bioelectronic implants after spinal cord injury [0.03%]
脊髓损伤后涉及生物电子植入物的神经修复干预措施
Newton Cho,Jordan W Squair,Jocelyne Bloch et al.
Newton Cho et al.
In the absence of approved treatments to repair damage to the central nervous system, the role of neurosurgeons after spinal cord injury (SCI) often remains confined to spinal cord decompression and vertebral fracture stabilization. However...
Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity [0.03%]
通过解码小鼠迷走神经活动识别低血糖特异性神经信号
Emily Battinelli Masi,Todd Levy,Tea Tsaava et al.
Emily Battinelli Masi et al.
Background: Glucose is a crucial energy source. In humans, it is the primary sugar for high energy demanding cells in brain, muscle and peripheral neurons. Deviations of blood glucose levels from normal levels for an exte...
Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy [0.03%]
心脏再生的启发性想法——未来神经调控心脏治疗方向
Emma B Brandt,S Janna Bashar,Ahmed I Mahmoud
Emma B Brandt
Ischemic heart disease is the leading cause of death worldwide. The blockade of coronary arteries limits oxygen-rich blood to the heart and consequently there is cardiomyocyte (CM) cell death, inflammation, fibrotic scarring, and myocardial...
Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches [0.03%]
脑片中谷氨酸能突触传递和可塑性的评估：与生物电子学方法的相关性
Eric H Chang,Samantha T Carreiro,Stephen A Frattini et al.
Eric H Chang et al.
Background: Glutamatergic neurons represent the largest neuronal class in the brain and are responsible for the bulk of excitatory synaptic transmission and plasticity. Abnormalities in glutamatergic neurons are linked to...
Valentin A Pavlov
Valentin A Pavlov
Studies on the role of the vagus nerve in the regulation of immunity and inflammation have contributed to current preclinical and clinical efforts in bioelectronic medicine. In parallel, this research has generated new insights into the cel...
Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear [0.03%]
应用于外耳的振动触觉装置治疗类风湿性关节炎的研究
Meghan E Addorisio,Gavin H Imperato,Alex F de Vos et al.
Meghan E Addorisio et al.
Background: Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory disease characterized by extensive joint tissue inflammation. Implantable bioelectronic devices targeting the inflammatory reflex reduce TNF...
Design and testing of a 96-channel neural interface module for the Networked Neuroprosthesis system [0.03%]
一种用于神经假体系统的96通道神经接口模块的设计与测试
Autumn J Bullard,Samuel R Nason,Zachary T Irwin et al.
Autumn J Bullard et al.
Background: The loss of motor functions resulting from spinal cord injury can have devastating implications on the quality of one's life. Functional electrical stimulation has been used to help restore mobility, however, ...