Promising Effects of CAR T-Cell Therapy in Refractory Stiff Person Syndrome and a Hopeful Future for All Neuroautoimmunities [0.03%]
CAR-T细胞治疗难治性僵人综合征的疗效观察及对所有神经免疫性疾病治疗前景的展望
Marinos C Dalakas
Marinos C Dalakas
Chimeric antigen receptor (CAR) T cells are genetically modified T cells expressing CARs, initially developed to recognize tumor antigens and kill cancer cells that evade T-cell recognition. Because of their impressive success in hemato-onc...
IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy [0.03%]
多灶性运动神经病的诱导 pluripotent stem cell衍生的 motor neuron模型中的IgM抗ganglioside结合和补体激活
Daniëlle Krijgsman,Kim Dijkxhoorn,Elisabeth de Zeeuw et al.
Daniëlle Krijgsman et al.
Background and objectives: Multifocal motor neuropathy (MMN) is an asymmetric motor neuropathy driven by IgM autoantibodies targeting gangliosides, particularly GM1. In this study, we investigated the relationship between...
Quality Control for Retinal Optical Coherence Tomography Angiography in Multiple Sclerosis: A Validation Study of the OSCAR-MP Criteria [0.03%]
optic coherence tomography血管造影的光学相干断层扫描视网膜质量控制的OSCAR-MP标准验证研究多重硬化症中的angiography in multiple sclerosis: a validation study of the oscar-mp criteria
Rebecca Wicklein,Elisabeth Wolf,Marc Grziwotz et al.
Rebecca Wicklein et al.
Objectives: Optical coherence tomography angiography (OCTA) is widely used for evaluating retinal vessels. The aim of this study was to assess the influence of OCTA quality, as measured by the previously introduced OSCAR-...
Incidence, Etiology, and Long-Term Outcome of Acute Myelitis in Stockholm County, Sweden: A Population-Based Study [0.03%]
瑞典斯德哥尔摩县急性髓系白质炎的发病、病因及长期预后：一项基于人群的研究
Dagur Ingi Jonsson,Olafur Sveinsson,Nina Moeini et al.
Dagur Ingi Jonsson et al.
HTLV-1-Specific CTL Accumulation in CSF Contributes to Neuroinflammation in HTLV-1-Associated Myelopathy [0.03%]
HTLV-1特异性CTL在脑脊液中聚集可促进HTLV-1相关脊髓病的神经炎症反应
Satoshi Nozuma,Mika Dozono,Masakazu Tanaka et al.
Satoshi Nozuma et al.
Background and objectives: Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurologic disorder characterized by chronic inflammation in the CNS. HTL...
Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy [0.03%]
儿童多发性硬化症患者的顺磁性边缘病变及其与脑组织萎缩的关系
Riccardo Nistri,Ermelinda De Meo,Nee Na Kim et al.
Riccardo Nistri et al.
Background and objectives: Paramagnetic rim lesions (PRLs), visible on susceptibility-based imaging (SbI), reflect chronic active inflammation in multiple sclerosis (MS). In adult-onset MS, PRLs are associated with a more...
Refractory Tumorous and Neurodegenerative Histiocytosis Treated With Intra-Arterial Chemotherapy [0.03%]
用于治疗肿瘤性及神经退行性朗格汉斯组织细胞增生症的血管内化疗
Alexander Ramos,Andrew L A Garton,Jared Knopman et al.
Alexander Ramos et al.
Background and objectives: Histiocytoses are diverse hematopoietic diseases with disabling neurologic involvement. Recently, targeted mitogen-activated protein kinase pathway inhibitors have been used with clinical and ra...
Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis: Markers of Severity and Outcome [0.03%]
抗LGI1脑炎中细胞因子和化学因子谱型：严重程度和结果的标志物
Guillermo Muñoz-Sánchez,Mar Guasp,Amaia Muñoz-Lopetegi et al.
Guillermo Muñoz-Sánchez et al.
Background and objectives: Anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis is the most common antibody-mediated encephalitis in adults older than 50 years. In addition to antibody effects, cytokines and ch...
Lymphocyte Dynamics and the Emergence of Secondary Autoimmunity Following Immune Reconstitution Therapies in Multiple Sclerosis [0.03%]
免疫重建疗法后淋巴细胞动态变化与多发性硬化症二次自身免疫的出现
Sofia Sandgren,Lenka Novakova,Markus Axelsson et al.
Sofia Sandgren et al.
Background and objectives: Understanding the immunologic changes induced by immune reconstitution therapies (IRTs) is key to optimizing multiple sclerosis (MS) treatment. We evaluate lymphocyte dynamics and their associat...
Plasma N-Glycan Profiling Enhances Diagnostic Precision in Multiple Sclerosis, AQP4-Ab NMOSD, and MOGAD [0.03%]
血浆N连接型聚糖谱分析可提高多发性硬化、AQP4-IgG NMOSD和MOGAD的诊断精度
Tereza Kacerova,Megan Sealey,Luisa Saldana et al.
Tereza Kacerova et al.
Background and objectives: Differentiating multiple sclerosis (MS) from antibody (Ab)-defined diseases, such as neuromyelitis optica spectrum disorders (NMOSDs), remains challenging, particularly as Ab levels decline. N-g...