Double-Negative Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis [0.03%]
双阴性 neuromyelitis optica 光谱疾病：系统回顾和荟萃分析
Antonio Malvaso,Francesca Bovis,Giacomo Greco et al.
Antonio Malvaso et al.
Background and objectives: Neuromyelitis optica spectrum disorder (NMOSD) is a severe condition usually associated with aquaporin-4 (AQP4) antibodies. A clinical presentation suggestive of NMOSD can also be associated wit...
Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALS [0.03%]
多重标志物检测面板可检测散发性和C9orf72-ALS中的胶质细胞和炎症生物标志物特征
Karthik Baskar,Christina Steffke,Sarah Bernsen et al.
Karthik Baskar et al.
Background and objectives: CSF proteomics has emerged as a valuable strategy for identifying diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis (ALS). However, the limited availability and volumes of CS...
Cerebellar Atrophy in Pediatric-Onset Opsoclonus-Myoclonus-Ataxia Syndrome: A Large International Cohort Study [0.03%]
儿童期起病的感觉神经不良性肌阵挛共济失调综合征的齿状核萎缩：一项大规模国际队列研究
Rebecca MacRae,Kierstin Hederstedt,Christopher Cortina et al.
Rebecca MacRae et al.
Background and objectives: Pediatric-onset opsoclonus-myoclonus-ataxia syndrome (POOMAS) is a rare, neuroinflammatory syndrome that targets the cerebellum and can cause irreversible cerebellar structural changes, namely c...
Rick S Dersch,Steffen Pfeuffer,Gabriel Bsteh et al.
Rick S Dersch et al.
Over the past decade, therapeutic paradigms in multiple sclerosis have shifted toward a "hit-hard-and-early" approach to suppress inflammatory activity and delay progression. However, adverse events, safety concerns, aging, comorbidities, a...
TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-IgG Test Results [0.03%]
真正的MOGAD评分系统：一种识别阳性MOG-IgG检测结果中MOGAD的新型评分系统
Andreu Vilaseca,Angeliki G Filippatou,Yana Said et al.
Andreu Vilaseca et al.
Long-Term Ravulizumab Efficacy and Safety in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder: Final CHAMPION-NMOSD Results [0.03%]
Ravulizumab在AQP4抗体阳性神经免疫性疾病中的长期疗效和安全性：CHAMPION-NMOSD研究的最终结果
Sean J Pittock,Michael H Barnett,Jeffrey L Bennett et al.
Sean J Pittock et al.
Background and objectives: Ravulizumab, a complement component 5 inhibitor, was approved for the treatment of adults with anti-aquaporin-4 antibody-positive (AQP4-Ab+) neuromyelitis optica spectrum disorder (NMOSD) based ...
Muscle Regeneration Failure May Lead to Clinical Features of Myopathy in Anti-IgLON5 Disease [0.03%]
抗IgLON5病肌无力的临床特征可能与肌肉再生失败有关
Yvette S Crijnen,Verena Endmayr,Suzanne C Franken et al.
Yvette S Crijnen et al.
Background and objectives: Anti-immunoglobulin-like cell adhesion molecule 5 (IgLON5) disease is a novel and potentially treatable entity. Therefore, it is important to recognize all clinical symptoms and diagnostic clues...
Abnormal B-Cell Exosome Proapoptotic and Antiapoptotic Cargo in Multiple Sclerosis: Potential Implication in Progressive Disease Biology [0.03%]
多发性硬化症中B细胞外泌体促凋亡和抗凋亡载荷的异常：在进行性疾病生物学中的潜在意义
Gautier Breville,Ayman Rezk,Samuel Weissman et al.
Gautier Breville et al.
Background and objectives: Compartmentalized CNS inflammation involving B cells is implicated in gray matter injury and disease progression in multiple sclerosis (MS). Products secreted by B cells of patients with MS can ...
Isolated Peripheral Nervous System Presentation in Ma/Ma2-Associated Autoimmunity [0.03%]
Ma/Ma2相关自身免疫的外周神经系统局灶性受累
Andreu Vilaseca,Macarena Villagrán-García,Antonio Farina et al.
Andreu Vilaseca et al.
Objectives: Ma/Ma2-associated neurologic autoimmunity is characterized by CNS involvement. However, isolated peripheral nervous system (PNS) presentations have been rarely reported. We aimed to describe the frequency and ...
Immunity Gone Viral: Subacute Cognitive Decline With Multifocal Brain Lesions in Neuromyelitis Optica Spectrum Disorder [0.03%]
NMOSD并发亚急性脑认知损害及多发病灶的免疫相关性研究
Sonali Ajwani,Brian G Weinshenker,Caterina Giannini et al.
Sonali Ajwani et al.
Subacute cognitive decline and imbalance in aquaporin-4-antibody-seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD) treated with mycophenolate has a broad differential diagnosis, including cerebral involvement of AQP4+NMOSD, i...