Real-World Efficacy and Safety of Neuromyelitis Optica Spectrum Disorder Disease-Modifying Treatments [0.03%]
neuromyelitis optica spectrum disorder疾病修正治疗的现实世界有效性和安全性
Philippe A Bilodeau,Mattia Wruble Clark,Avanteeka Ganguly et al.
Philippe A Bilodeau et al.
Background and objectives: Neuromyelitis optica spectrum disorder (NMOSD) is characterized by inflammatory relapses that result in severe disability, including blindness and paralysis. Relapse prevention with safe and eff...
Sex Bias in IL-10 Production by Type I Regulatory T Cells Regulated by PI3K/mTOR Signaling [0.03%]
PI3K/mTOR信号调控I型调节性T细胞中白介素-10产生的性别差异
Aymeline Debonlier,Saniya Kari,Florence Bucciarelli et al.
Aymeline Debonlier et al.
Background and objectives: Multiple sclerosis (MS) is more prevalent in women, with a female-to-male ratio of 3:1. The molecular mechanisms driving this sex difference are still mostly unknown. MS results from immune dysf...
Complement C4d Informs the Differential Diagnosis of Inflammatory Demyelinating CNS Diseases [0.03%]
补体C4d指导炎症性脱髓鞘中枢神经系统疾病的鉴别诊断
Carolin Landt,Friederike Held,Konstantina Kolotourou et al.
Carolin Landt et al.
Background and objectives: Complement-targeting therapies are pivotal in managing neuromyelitis optica spectrum disorder (NMOSD), calling for a deeper understanding of complement activation across idiopathic inflammatory ...
Progression Independent of Relapse Activity in Aquaporin-4-IgG-Positive NMOSD: A Decade-Long Cohort Study [0.03%]
抗水通道蛋白-4抗体阳性NMOSD患者独立于复发活动的病情进展：一项十年纵向队列研究
You-Ri Kang,Ki Hoon Kim,Jae-Won Hyun et al.
You-Ri Kang et al.
Objectives: Disability in neuromyelitis optica spectrum disorder (NMOSD) is traditionally considered relapse-driven, but recent studies have suggested possible subclinical progression. Whether this translates into clinica...
Enterovirus Encephalitis in People With Multiple Sclerosis on Ocrelizumab: Insights From a Multicenter Case Series [0.03%]
奥塞利珠单抗治疗的多发性硬化患者中的肠道病毒性脑炎：来自一项多中心病例系列的新观点
Samantha A Banks,Ilia Poliakov,Eoin P Flanagan et al.
Samantha A Banks et al.
Objectives: Anti-CD20 therapies for multiple sclerosis (MS) are highly effective at preventing disease activity. Recognizing infectious complications of these therapies is essential. ...
Astrocyte Biology in CNS Inflammatory Diseases: A Clinical-Translational Perspective [0.03%]
中枢神经系统炎症性疾病中星形胶质细胞生物学的临床转化视角
Jessica Ye,Francisco J Quintana
Jessica Ye
Astrocytes are the main structural cells of the brain and spinal cord. Tessellating throughout the entire tissue, these highly arborized cells form intimate connections with each other and with essentially all other cell types in the CNS, i...
Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity [0.03%]
患者衍生的单克隆髓磷脂少突胶质细胞糖蛋白自身抗体具有细胞毒性
Nora Sandrine Wetzel,Laila Kulsvehagen,Anne-Catherine Lecourt et al.
Nora Sandrine Wetzel et al.
Background and objectives: Serum myelin oligodendrocyte glycoprotein (MOG) antibodies are a hallmark of the newly defined neuroinflammatory disease entity MOG antibody-associated disease (MOGAD). Yet, the lack of patient-...
Treg Susceptibility to Cladribine-Induced Depletion Correlates With Therapy Response in Patients With Multiple Sclerosis [0.03%]
调节性T细胞对克拉溴马林诱导的消耗敏感性与多发性硬化症患者的治疗反应相关
Ilenia Cammarata,Giorgia Sartori,Tiziano Giacomelli et al.
Ilenia Cammarata et al.
Background and objectives: Immune reconstitution therapies for multiple sclerosis (MS) are based on selective lymphocyte reduction, followed by repopulation and rescue of immune tolerance. Among these therapies, cladribin...
MOG IgG3-Subclass Antibodies in MOG-Associated Disease: Insights From a Pediatric Case With IgG1 Deficiency and Literature Review [0.03%]
视神经脊髓炎谱系疾病相关MOG-IgG1低下患者的IgG3亚型抗体研究：一例儿科患者报道及文献复习
Anna Fetta,Francesca Conti,Agnese Lopalco et al.
Anna Fetta et al.
Objectives: This report details a pediatric case of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) characterized by isolated MOG-IgG3 positivity and IgG1 deficiency, highlighting a unique serologic profile a...
High Relapse Rate in Anti-CASPR2 Disease: Implications for Prolonged Immunotherapy [0.03%]
高复发率的CASPR2抗体病：长期免疫治疗的含义
Tessa Brand,Suzanne Claudia Franken,Marie R Vermeiren et al.
Tessa Brand et al.
Background and objectives: Anti-contactin-associated protein-like 2 (CASPR2) disease-previously considered a subtype of anti-voltage-gated potassium channel (VGKC-complex) encephalitis-is a relatively new disease entity, ...