Sara Carta,Riccardo Tiberi,Nicola De Rossi et al.
Sara Carta et al.
Objectives: A score evaluating age at onset, sex, clinical phenotype, and treatment received (MOG-AR) has been proposed to identify MOGAD patients at high relapse risk. The aim of this study was to validate the MOG-AR sco...
Peripheral Immune Remodeling After Spinal Cord Injury: Marked by Expansion of CD38+, CTLA-4+, and PD-1+ T and NK Cells [0.03%]
脊髓损伤后的外周免疫重塑：CD38+，CTLA-4+和PD-1+T和NK细胞扩增标志
Naomi Veeningen,Ana Laura Añé-Kourí,Astrid Pues et al.
Naomi Veeningen et al.
Background and objectives: Spinal cord injury (SCI) is associated with severe immunologic changes, such as SCI-induced immune deficiency syndrome, which heightens susceptibility to infections. However, the immune componen...
Shuaikun Kang,Qingqing Wang,He Lv et al.
Shuaikun Kang et al.
Objectives: Dysferlinopathy is an autosomal recessive muscular dystrophy caused by pathogenic variants of the DYSF gene. Currently, no clinical effective treatment is available. Given the myopathologic and animal model ev...
Interleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain [0.03%]
白细胞介素-9调节NF-κB介导的多发性硬化脑星形胶质细胞活化作用
Miriam Cinotti,Susanna Amadio,Daniele Tidei et al.
Miriam Cinotti et al.
Background and objectives: Interleukin-9 (IL-9) is an immune molecule with multiple roles in a variety of cell types. IL-9-induced cell responses are mediated by the IL-9 receptor (IL-9R). Recent evidence demonstrates tha...
Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS [0.03%]
解码TREM2信号通路：连接小胶质细胞糖酵解与中枢神经系统炎症疾病
Yanfei Che,Ziman Yu,Songjie Ji et al.
Yanfei Che et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a key immunomodulatory receptor broadly expressed on myeloid cells such as macrophages and microglia. It plays versatile roles in neurodegenerative diseases, tissue repair, and tum...
Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy [0.03%]
补体异常激活是慢性炎症性脱髓鞘多发性神经病的显著特征
Frauke Stascheit,Hannah Preßler,Kerstin Stein et al.
Frauke Stascheit et al.
Objectives: To comprehensively characterize complement pathway activation in chronic inflammatory demyelinating polyneuropathy (CIDP) and its association with clinical disease features using advanced complement profiling....
OCT-Based Differentiation of First Acute Optic Neuritis: An International Study of 111 Patients With NMOSD and MOGAD [0.03%]
基于OCT的第一急性视神经炎的NMOSD和MOGAD患者的鉴别国际研究(111例患者)
Thivya Pakeerathan,James Davis,Amanda D Henderson et al.
Thivya Pakeerathan et al.
Background and objectives: Severe optic neuritis (ON) is a common clinical manifestation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD). Given...
Systematic Review and Meta-Analysis of the Clinical Features Associated With Seronegative Autoimmune Encephalitis [0.03%]
自身免疫性脑炎相关临床特征的系统评价和荟萃分析
Leonardo Di Cosmo,Smaila Mulic-Al Bunni,Yihui Goh et al.
Leonardo Di Cosmo et al.
Background and objectives: Seronegative autoimmune encephalitis (AE), defined by an appropriate clinical phenotype in the absence of known neuronal autoantibodies, poses diagnostic and therapeutic challenges due to clinic...
HLA and T-Cell Receptor Investigations in Idiopathic and Paraneoplastic Opsoclonus-Myoclonus in Children [0.03%]
儿童特发性和副肿瘤性眼肌阵挛-肌阵挛的小胶质细胞抗原和T细胞受体研究
Gemma Olivé-Cirera,Guillermo Muñoz-Sánchez,Eduard Palou et al.
Gemma Olivé-Cirera et al.
Background and objectives: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare pediatric autoimmune neurologic disorder, with 40%-50% of cases occurring as a paraneoplastic syndrome in the setting of neuroblastoma or ot...
Relative Frequency and Distinctive Features of Anti-Ma2 Nonparaneoplastic Neurologic Disorders: A French Cohort Study [0.03%]
抗Ma2非肿瘤性神经病的相对频率和特异性特征：一项基于法国人群的研究
Mantas Vaisvilas,Gemma Lafuente-Gómez,Macarena Villagrán-García et al.
Mantas Vaisvilas et al.
Background and objectives: Although anti-Ma2 antibodies (Ma2-Abs) typically associate with paraneoplastic encephalitis, a subset of patients with Ma2-Abs does not have any detectable tumor. The clinical specificities of t...