Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis [0.03%]
整合素β1鉴定出多发性硬化症中产生抗体前体细胞的位置标志物
Kirsten L Kuiper,Laurens Bogers,Jasper Rip et al.
Kirsten L Kuiper et al.
Background and objectives: Multiple sclerosis (MS) is characterized by CXCR3+ memory B cells that infiltrate the CNS to mature into antibody-secreting cells (ASCs). It remains elusive how to benefit from this disease hall...
miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis [0.03%]
原发进展型多发性硬化症患者脑脊液中的miRNA特征谱分析研究
María Muñoz-San Martín,Imma Gómez,Ana Quiroga-Varela et al.
María Muñoz-San Martín et al.
Clinical Features and Biomarkers Associated With Intensive Care-Dependent Refractory NMDAR Encephalitis: A Retrospective Cohort Study [0.03%]
重症难治性N-甲基-D-天冬氨酸受体脑炎的临床特征和生物标志物：回顾性队列研究
Iker Elosua-Bayes,Pauline Dumez,Marie Benaiteau et al.
Iker Elosua-Bayes et al.
Background and objectives: A subset of patients with NMDAR encephalitis is resistant to first-line and second-line immunotherapy and requires prolonged intensive care. The clinical definition of refractory, intensive care...
Reduced Hospital Incidence of Autoimmune Encephalitis During the COVID-19 Pandemic [0.03%]
新冠疫情期间自身免疫性脑炎的住院发病率降低
Jonathan Wickel,Ha-Yeun Chung,Franz Felix Konen et al.
Jonathan Wickel et al.
Objectives: The aim of this study was to analyze changes in hospital incidence cases and disease severity of autoantibody-associated autoimmune encephalitis (AE) during the COVID-19 pandemic compared with the prepandemic ...
Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study [0.03%]
多发性硬化患者显示出国别差异性的犬尿氨酸代谢途径模式：一项跨国横断面研究
Marie Kupjetz,Martin Langeskov-Christensen,Morten Riemenschneider et al.
Marie Kupjetz et al.
Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks: Insights From an International Case Series [0.03%]
补体抑制在急性神经肌病视神经谱系障碍发作中的作用：国际病例系列的见解
Paulus S Rommer,Wei Jiang,Jan P Nolte et al.
Paulus S Rommer et al.
Background and objectives: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune disease mainly driven by aquaporin-4 antibodies (AQP4-IgG). During an attack, AQP4-IgG activates the complement system, lead...
Comparative Effectiveness of Disease-Modifying Treatments in Double Seronegative Neuromyelitis Optica Spectrum Disorder [0.03%]
双阴性神经免疫性疾病治疗药物疗效的比较研究
Joao Vitor Mahler,Gerome B Vallejos,Takahisa Mikami et al.
Joao Vitor Mahler et al.
Background and objectives: Double seronegative NMOSD (DS-NMOSD) lacks approved disease-modifying treatments, and limited data exist on optimal relapse-prevention strategies. In this multicenter, international, retrospecti...
Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinical Trial of Newly Diagnosed Glioblastoma [0.03%]
烟酸通过I期剂量递增临床试验调节新诊断胶质母细胞瘤的免疫反应
Candice C Poon,Kathleen M Hagen,Susobhan Sarkar et al.
Candice C Poon et al.
Background and objectives: Glioblastoma, a highly aggressive and uniformly lethal brain tumor, resists current treatments and immunotherapies by creating a potently immunosuppressive microenvironment. The objective of thi...
Brain-Resident MAIT Cells Infiltrate GL261 Tumors, and Activated MAIT Cell Signatures Are Associated With Improved Outcomes in Glioma [0.03%]
脑驻留的MAIT细胞浸润GL261肿瘤，活化的MAIT细胞谱型与胶质瘤预后改善相关
Eleanor M Eddy,Md Abdullah Al Kamran Khan,Timothy Patton et al.
Eleanor M Eddy et al.
Background and objectives: Mucosal-associated invariant T (MAIT) cells are unconventional T cells with emerging roles in antitumor immunity. Their phenotype in the brain and potential role in immunity to gliomas-including...
EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis: Evidence From Integrated Viral and Host Analyses [0.03%]
EB病毒调节异常与多发性硬化免疫失衡相关性证据来自整合的病毒及宿主分析
Chiara Meloni,Fabiana Marnetto,Corrado Fagnani et al.
Chiara Meloni et al.
Background and objectives: Epstein-Barr virus (EBV) infection is a prerequisite for the development of multiple sclerosis (MS), yet whether EBV acts merely as a trigger at disease onset or also contributes to immune dysre...